RESUMEN
Metal complexes of cetirizine·2HCl (CTZ=2-[2-[4-[(4-chlorophenyl)phenyl methyl]piperazine-1-yl]-ethoxy]acetic acid, dihydrochloride have been prepared and characterized by elemental analyses, IR, solid reflectance, magnetic moment, molar conductance, and UV-Vis spectra. The analytical data of the complexes show the formation of 1:2 [M:L] ratio, where M represents Ni(II), Co(II) and Cu(II) ions, while L represents the deprotonated CTZ ligand. IR spectra show that CTZ is coordinated to the metal ions in a monodentate manner through carboxylate-O atom. Protonation equilibria of CTZ and its metal complexation by some divalent metal ions were determined in aqueous solution at constant ionic strength (0.1 M NaCl) using an automatic potentiometric technique. Thermodynamic parameters for the protonation equilibria of CTZ were calculated and discussed. The stability order of M(II)-CTZ complexes were found to obey Mn(2+)Asunto(s)
Antibacterianos/química
, Antifúngicos/química
, Cetirizina/química
, Complejos de Coordinación/química
, Elementos de Transición/química
, Antibacterianos/farmacología
, Antifúngicos/farmacología
, Bacterias/efectos de los fármacos
, Infecciones Bacterianas/tratamiento farmacológico
, Cetirizina/farmacología
, Complejos de Coordinación/farmacología
, Hongos/efectos de los fármacos
, Humanos
, Pruebas de Sensibilidad Microbiana
, Micosis/tratamiento farmacológico
, Análisis Espectral
, Termodinámica
, Elementos de Transición/farmacología