Clinical Characteristics of EGPA Patients in Comparison to GPA Subgroup with Increased Blood Eosinophilia from POLVAS Registry.

Objective: To characterize the eosinophilic granulomatosis with polyangiitis (EGPA) population from the POLVAS registry depending on ANCA status and diagnosis onset, including their comparison with the granulomatosis with polyangiitis (GPA) subset with elevated blood eosinophilia (min. 400/µl) (GPA HE) to develop a differentiating strategy. Methods: A retrospective analysis of the POLVAS registry. Results: The EGPA group comprised 111 patients. The ANCA-positive subset (n = 45 [40.54%]) did not differ from the ANCA-negative one in clinics. Nevertheless, cardiovascular manifestations were more common in ANCA-negative patients than in those with anti-myeloperoxidase (MPO) antibodies (46.97% vs. 26.92%, p = 0.045). Patients diagnosed before 2012 (n = 70 [63.06%]) were younger (median 41 vs. 49 years, p < 0.01), had higher blood eosinophilia at diagnosis (median 4,946 vs. 3,200/µl, p < 0.01), and more often ear/nose/throat (ENT) and cardiovascular involvement. GPA HE comprised 42 (13.00%) out of 323 GPA cases with reported blood eosinophil count. Both GPA subsets had a lower prevalence of respiratory, cardiovascular, and neurologic manifestations but more often renal and ocular involvement than EGPA. EGPA also had cutaneous and gastrointestinal signs more often than GPA with normal blood eosinophilia (GPA NE) but not GPA HE. The model differentiating EGPA from GPA HE, using ANCA status and clinical manifestations, had an AUC of 0.92, sensitivity of 96%, and specificity of 95%. Conclusion: Cardiovascular symptoms were more prevalent in the ANCA-negative subset than in the MPO-ANCA-positive one. Since EGPA and GPE HE share similarities in clinics, diagnostic misleading may result in an inappropriate therapeutic approach. Further studies are needed to optimize their differentiation and tailored therapy, including biologics.

Exploring the role of country-level gender equality in the link between relationship status and perceived social support across 49 countries.

Past studies have demonstrated that higher perceived social support among coupled individuals and greater gender equality foster a more supportive social context. Less is known about how the link between relationship status and perceived social support may vary across countries that differ in gender equality. Employing the data collected from the COVIDiSTRESS I (39 countries; N = 99,075) and COVIDiSTRESS II (23 countries; N = 8293) projects, we examined whether country-level gender equality moderates the link between relationship status and perceived social support. Multilevel regression analyses indicated that gender equality moderated the link between relationship status and perceived social support. Single people in countries with less gender equality reported less perceived social support than was reported by both coupled people and single people from countries with moderate and high levels of gender equality, however, the effect of the interaction between relationship status and gender equality on perceived social support was very low. The results suggest that gender equality fosters perceived social support, both for single people and for partnered people.

Loneliness among single and coupled individuals in response to the COVID-19 pandemic: A cross-country analysis

Background/Objective: Research suggests that the COVID-19 pandemic has increased social isolation and loneliness and that, in general, single individuals experience a higher degree of loneliness than coupled individuals. Loneliness may also vary across cultures as a function of social norms and Hofstede's dimensions of national culture. Therefore, the aim of the present study was to examine whether the link between relationship status and loneliness in the context of the COVID-19 pandemic differed across countries as a function of cultural values captured in terms of Hofstede's six dimensions of national culture. Method: Multilevel modeling was used to analyze the archival data collected in the COVIDiSTRESS Global Survey (41 countries and 102,957 participants) and the COVIDiSTRESS Global Survey - Round II (23 countries and 8227 participants). Results: The analyses demonstrated the statistical significance of the interactions between relationship status and six Hofstede's dimensions of national culture in the link between relationship status and loneliness. The estimated effect sizes of these interactions were, however, almost zero. Conclusions: The lack of effect size of the interactions between relationship status and Hofstede's dimensions of national culture for loneliness may have substantive significance. This finding implies that, on average, loneliness as a function of relationship status may be less reactive in the context of the COVID-19 pandemic to the effects of social norms and values across which countries vary. (AU)

Work anxiety factors, coronavirus anxiety and job satisfaction of Polish nurses facing COVID-19 pandemic outbreak.

BACKGROUND: During the SARS-CoV-2 pandemic, as in past disasters and emergencies, nurses around the world play an important role. What is more, the unprecedented pressure exerted by the pandemic on healthcare systems in every country brings big challenges to nurses, which may affect their well-being, work efficacy and job satisfaction. OBJECTIVE: The main objective of the presented studies was to describe anxiety factors related to the work of nurses during the SARS-CoV-2 pandemic; to assess the intensity of coronavirus anxiety and job satisfaction experienced by nurses at that time; to assess predictors of job satisfaction of nurses during the COVID-19 pandemic; to assess the differences in the intensity of job satisfaction and coronavirus anxiety depending on the selected variables related to their experiences during the COVID-19 pandemic. DESIGN: Anonymous questionnaire surveys were conducted online among the participants between 23 June 2020 and 23 March 2022 in Poland. PARTICIPANTS: 433 nurses from 15 Polish provinces were included in the studies (age range 22-68; M = 41.63). Nursing seniority M = 18.6. METHODS: The studies were based on: Satisfaction with Job Scale (SSP), Coronavirus Anxiety Scale (CAS), and a self-report structured questionnaire. RESULTS: The most respondents indicated that they were afraid of becoming infected with SARS-CoV-2 (25.4 %), transmitting infection to the family (22.4 %), becoming sick with COVID-19 and experiencing health complications (6.7 %) and of excessive work responsibilities and physical fatigue (6.5 %). Based on the bivariate correlation, it can be concluded that job satisfaction of the respondents during the COVID-19 pandemic was on an average level (M = 19.9); coronavirus anxiety was on an average level (M = 4.9), and stress at work was on a high level (M = 7.1). Coronavirus anxiety did not constitute statistically significant predictors of job satisfaction of subjects studied during the pandemic (SE = 0,048; ß = 0,05; p = 0.942). CONCLUSIONS: Coronavirus anxiety wasn't associated with job satisfaction of nurses directly. Job satisfaction of nurses during the COVID-19 pandemic was likely to be shaped by a range of different factors. TWEETABLE ABSTRACT: In Polish nurses coronavirus anxiety was average and wasn't associated with their job satisfaction.

Loneliness among single and coupled individuals in response to the COVID-19 pandemic: A cross-country analysis.

Background/Objective: Research suggests that the COVID-19 pandemic has increased social isolation and loneliness and that, in general, single individuals experience a higher degree of loneliness than coupled individuals. Loneliness may also vary across cultures as a function of social norms and Hofstede's dimensions of national culture. Therefore, the aim of the present study was to examine whether the link between relationship status and loneliness in the context of the COVID-19 pandemic differed across countries as a function of cultural values captured in terms of Hofstede's six dimensions of national culture. Method: Multilevel modeling was used to analyze the archival data collected in the COVIDiSTRESS Global Survey (41 countries and 102,957 participants) and the COVIDiSTRESS Global Survey - Round II (23 countries and 8227 participants). Results: The analyses demonstrated the statistical significance of the interactions between relationship status and six Hofstede's dimensions of national culture in the link between relationship status and loneliness. The estimated effect sizes of these interactions were, however, almost zero. Conclusions: The lack of effect size of the interactions between relationship status and Hofstede's dimensions of national culture for loneliness may have substantive significance. This finding implies that, on average, loneliness as a function of relationship status may be less reactive in the context of the COVID-19 pandemic to the effects of social norms and values across which countries vary.

Activity of granulomatosis with polyangiitis and its correlation with mTOR phosphoproteomics in neutrophils.

Introduction: Granulomatosis with polyangiitis (GPA) is a small vessel vasculitis with a complex pathomechanism. Organ damage in GPA is also mediated by extracellular trap formation (NETosis). We analyzed the functional status of phosphoproteins modulating NETosis in neutrophils by the mammalian target of rapamycin (mTOR) pathway in GPA along with NETosis biomarkers. Methods: Phosphoproteins levels measured in isolated neutrophils from 42 patients with GPA (exacerbation n=21; remission n=21) and 21 healthy controls were compared to serum biomarkers of the disease. Results: Neutrophils in active disease manifested lowered levels of phosphorylated mTOR(Ser2448), PTEN(Ser380) and ULK1(Ser555), whereas phosphorylated GSK-3α/ß(Ser21/Ser9) was elevated. Exacerbation of GPA was characterized by elevated neutrophil dsDNA in serum, circulating mitochondrial DNA, and DNA-MPO complexes. A significant negative correlation between mTOR or PTEN phosphoproteins and biomarkers of GPA activity was also present, reflecting the clinical activity score of GPA. Positive correlations between phosphorylated GSK-3 α/ß and circulating mtDNA, DNA-MPO complexes, neutrophil-released dsDNA, or circulating proteins were also significant. Increased serum levels of IGFBP-2, TFF-3, CD147, and CHI3L1 accompanied GPA exacerbation, whereas DPP-IV levels were the lowest in active GPA. Using a principal component analysis basigin, PTEN and mTOR had the highest loadings on the discrimination function, allowing classification between active, remission, and control subjects with 98% performance. Conclusions: We present evidence that inhibited mTOR signaling accompanies NETosis in patients with GPA. The functional status of phosphoproteins suggests simultaneous activation of NETosis and autophagy. These results give rise to the study of autophagy as a mechanism underlying granuloma formation in GPA.

Relationship (in)congruency may differently impact mental health

Background: Being involved in romantic relationships has historically been related to better mental health compared to being single. However, research exploring heterogeneity within these status groups is still understudied. Our study examined the role of (in)congruency between relationship desire, dismissal, satisfaction with relationship status, and current relationship status on the mental health measured in terms of anxiety, depression, insomnia, and romantic loneliness. Method: The online questionnaire survey included 790 participants aged 18 – 40 (M = 26.51, SD = 5.60) at baseline and 421 at a 1-month follow-up. Participants represented five relationship statuses (single, casual dating, LAT relationships, cohabitation, and engagement/marriage). Results: Our results suggest that greater relationship desire and dismissal at baseline were associated with higher anxiety and depression in casual daters one month later, while greater relationship desire was linked to lower anxiety for individuals in living apart together relationships (LATs). Higher relationship dismissal in casual daters and engaged/married individuals was associated with lower insomnia. Higher satisfaction with relationship status was associated with lower depression in single individuals and lower romantic loneliness in cohabitors and engaged/married individuals. Conclusions: This study highlights that relationship (in)congruency may operate differently across various relationship status subgroups on mental health outcomes. (AU)

Functional magnetic resonance imaging for the assessment of autonomic dysfunction in patients with antineutrophil cytoplasmic antibody-associated vasculitides.

INTRODUCTION: Nervous system involvement is common in antineutrophil cytoplasmic antibody-associated vasculitides (AAV). While the involvement of the peripheral and central nervous system is well described, it is still unclear how and to what extent the autonomic nervous system (ANS) is affected. Functional magnetic resonance imaging (fMRI) can provide information on both structure and potential damage of the brain, as well as on the function of selected brain centers. OBJECTIVES: The aim of this study was to investigate the ANS dysfunction in AAV patients and its correlation with the results of fMRI performed during the Valsalva maneuver. PATIENTS AND METHODS: A total of 31 patients with AAV and 30 healthy controls were enrolled in the study. Each participant completed the Composite Autonomic Symptom Score (COMPASS)-31 questionnaire. MRI was performed using a 3T scanner. The participants were asked to perform the Valsalva maneuver according to the fixed protocol, and their airway pressure was monitored. During the maneuver, fMRI data were collected. The generalized least­ squares time series analysis and the region of interest (ROI) analysis were subsequently performed. RESULTS: The patients with AAV had a higher median COMPASS­ 31 score than the controls (12.86 vs 2.99, respectively; P <0.01). Structural MRI investigation did not reveal any significant differences between the groups. The brain centers involved in ANS function were detected during fMRI; however, the ROI analysis showed no differences between the study patients and controls. CONCLUSIONS: The patients with AAV reported symptoms related to the ANS dysfunction; however, no differences with respect to the functioning of the ANS brain centers were demonstrated between these patients and healthy controls in the fMRI study during the Valsalva maneuver.

Case report: Bilateral eye injuries in members of one family due to a cluster munition in Ukraine.

The aim of the study was to report the effects of surgical treatment of three victims of a cluster munition in Ukraine. A 32-year-old woman and her sons-6-year-old male twins-presented in Poland after 18 days of delay in treatment. All ocular injuries were bilateral. One of the boys presented with total retinal detachment and a post-traumatic cataract as well as corneal sutures in one eye and a post-traumatic cataract in the other eye. The other boy had already developed atrophy in one eye and a vitreous hemorrhage in the other eye. The woman suffered from bilateral post-traumatic cataract with multiple glass intraocular foreign bodies (IOFBs). The surgical treatment included cataract surgery with intraocular lens implantation in three eyes, removal of IOFBs in one eye, and enucleation of the atrophic eye with implantation of an ocular prosthesis preventing constriction of face tissues. The eye with retinal detachment underwent pars plana vitrectomy, and the vitreous hemorrhage resolved itself. Postoperatively, visual acuity improved significantly in four of six eyes. Only in the eye with an open-globe injury and persistent retinal detachment, the final visual acuity was still poor. In conclusion, cluster munition may lead to bilateral ocular trauma with IOFBs, open-and close-globe injuries, and severe vision loss if left untreated. Modern ophthalmic surgery leads to vision with IOL improvement and solving the eyes after severe combat injury.

Is elevated ENA-78 serum level a link between obstructive sleep apnea and atherosclerosis?

Obstructive sleep apnea (OSA) is a risk factor for cardiovascular disease, inflammation, and oxidative stress. This study compared serum levels of different factors in patients with carotid artery stenosis and with or without coexisting OSA. It also aimed to identify a molecule that may be crucial for the inflammatory process correlated with intermittent hypoxia. Sixty-eight subjects scheduled for surgical treatment of carotid artery stenosis were enrolled. Polygraphy was performed the night before the surgery. Morning levels of proinflammatory cytokines and chemotactic and angiogenic factors were measured. The most profound differences between the groups were found for ENA-78 serum concentration. However, as many factors could affect the results, further studies are needed to investigate the role of ENA-78 in atherosclerosis in patients suffering from OSA.

Let's Talk About Single Men: A Qualitative Investigation of Never Married Men's Experiences of Singlehood.

Existing research on singlehood has largely focused on the experiences of single women, and little is known about singlehood among men. The current investigation examined the experience of long-term singlehood through individual, semi-structured interviews with 22 never-married single men living in Poland who were aged 22-43 years. Thematic analysis revealed five key themes: (1) the sense of being deficient-is there something wrong with me?; (2) navigating outside the dominant discourse of traditional masculinity, marriage and family; (3) the benefits and downsides of singlehood; (4) adaptation to singlehood; and (5) the dilemma between waiting and actively searching for a romantic partner. An analysis of single men's narratives revealed that men experience their single status in the context of their various needs and hopes and as a status that determines their adult life course. This study contributes to the singlehood literature, highlighting the complexity of singlehood for men and the importance of traditional masculinity norms in experiencing long-term singlehood. These findings challenge stereotypical and unrealistic views of singlehood among men and have practical implications for psychotherapists, counsellors and educators working with single men.

Two case studies of the treatment of simple onycholysis with disappearing nail bed caused by trauma by combined pharmacological, orthonyxia and taping methods.

BACKGROUND: Simple onycholysis is a common complaint after trauma and consists in separation of the nail plate from the nail bed. If untreated, prolonged onycholysis may cause a disappearing nail bed (DNB) that leads to the shortening or narrowing of the nail plate. OBJECTIVES: This study is aimed at discussing possible treatment of chronic simple onycholysis with DNB by combined conservative methods. METHODS: Simple onycholysis and DNB treatment consists of Onygen® cream application, nail bed massages, bracing procedures and nail folds taping with kinesio tape. RESULTS: Long-lasting simple onycholysis with DNB may be fully eliminated by applying the combined pharmacological, orthonyxia and taping treatment. CONCLUSION: Advanced simple onycholysis, which leads to the DNB and, in consequence, to the shortening or narrowing of the nail plate, causes cosmetic discomfort for patients. A damaged nail apparatus is also more susceptible to new traumas. Even long-standing onycholysis with DNB can be successfully treated with easy-to-apply conservative methods. The key point of therapy is the use of several methods of treatment with different effects on the nail apparatus. The effects of described therapy are highly satisfactory, the only drawback being its long term, which is caused by slow growth of the nails.

Relationship (in)congruency may differently impact mental health.

Background: Being involved in romantic relationships has historically been related to better mental health compared to being single. However, research exploring heterogeneity within these status groups is still understudied. Our study examined the role of (in)congruency between relationship desire, dismissal, satisfaction with relationship status, and current relationship status on the mental health measured in terms of anxiety, depression, insomnia, and romantic loneliness. Method: The online questionnaire survey included 790 participants aged 18 - 40 (M = 26.51, SD = 5.60) at baseline and 421 at a 1-month follow-up. Participants represented five relationship statuses (single, casual dating, LAT relationships, cohabitation, and engagement/marriage). Results: Our results suggest that greater relationship desire and dismissal at baseline were associated with higher anxiety and depression in casual daters one month later, while greater relationship desire was linked to lower anxiety for individuals in living apart together relationships (LATs). Higher relationship dismissal in casual daters and engaged/married individuals was associated with lower insomnia. Higher satisfaction with relationship status was associated with lower depression in single individuals and lower romantic loneliness in cohabitors and engaged/married individuals. Conclusions: This study highlights that relationship (in)congruency may operate differently across various relationship status subgroups on mental health outcomes.

Psychometric functioning, measurement invariance, and external associations of the Relationship Assessment Scale in a sample of Polish Adults.

The current article reports data from three Polish samples to examine the Relationship Assessment Scale (RAS) with respect to its unidimensionality, invariance across countries, gender, formal and informal relationships, degree of precision (or information) across latent levels of relationship satisfaction, and the functioning of individual items. The analyses of the data from the reference sample (n = 733) confirmed a clear 1-factor structure of the RAS-PL and good internal consistency. Configural, metric, and scalar invariance for countries (Poland, Hungary, USA), gender (women and men) and relationship types (formal and informal relationships) were achieved. Item Response Theory Analysis (IRT) suggested that the RAS-PL assesses relationship satisfaction most reliably at low to average levels. Analyses of the data from validation samples (n = 203 and n = 209) confirmed the convergent and divergent validity by weak, medium, and large correlations of the RAS-PL with measures of other theoretically related constructs. Concurrent criterion validity was demonstrated by a strong positive correlation between the RAS-PL and the intent to continue the current relationship. This investigation provides considerable psychometric information about the items and scale of the RAS-PL.

Polish version of the Depression Anxiety Stress Scale (DASS-42) - adaptation and normalization. / Polska wersja Skali Depresji Leku i Stresu (DASS-42) ­ adaptacja i normalizacja.

OBJECTIVES: This study aimed to present the Polish adaptation and preliminary normalization of the Depression Anxiety and Stress Scale - 42 (DASS-42). METHODS: The study was conducted among 1,021 participants (625 females and 396 males) aged 18-83 years (M = 30.67; SD = 13.25). It was a non-clinical sample. Second sample was a group of 49 psychiatric patients (28 females and 21 males) aged 22-76 years (M = 49.40; SD = 13.34). The reliability of the DASS-42 was measured using Cronbach's α coefficients and intraclass correlation coefficients (ICC). RESULTS: In the non-clinical sample the Cronbach's alpha coefficient was 0.93 points for the depression subscale; 0.89 points for the anxiety subscale; 0.92 for the stress subscale, and 0.96 for the DASS-42 total score. The ICC were satisfactory, between 0.37 and 0.49 points. Psychiatric patients obtained significantly higher results in all subscales and in a total score of the DASS-42 (p< 0.001) than healthy participants. It is an indicator of good concurrent validity of the method. The effect size of the differences for all questionnaire indicators was large (0.96

Visual Outcomes of Pupilloplasty in Ocular Trauma and Iatrogenic Damage.

PURPOSE: To report the visual outcomes of different techniques for iris pupilloplasty in eyes after traumatic and iatrogenic damage. METHODS: 70 consecutive eyes with posttraumatic (80%) and postoperative (20%) iris damage were included. According to the preoperative diagnosis, the eyes were divided into three groups: mydriasis (50%), partial iris defects (24%), and iridodialysis (26%). Multiple techniques were performed: the Siepser slip-knot technique, the "lasso" technique, and suturing to the sclera. These techniques were combined in some cases. RESULTS: The best improvement of visual acuity was found for the Siepser slip-knot technique with a median of 0.7 (SD ± 0.83) before surgery and 0.52 logMAR (SD ± 0.65) after surgery with regard to the surgical technique, and for mydriasis with a median of 0.7 (SD ± 0.75) before surgery and 0.52 logMAR (SD ± 0.49) after surgery with regard to preoperative diagnosis. Pupilloplasty was combined with additional surgery (corneal suturing, secondary intraocular lens implantation, anterior or pars plana vitrectomy) in 80% of cases. Apart from corneal suturing, all additional procedures ensured improvement in visual acuity. CONCLUSIONS: The slip-knot technique was the only suturing technique that resulted in a significant improvement in visual acuity. Other surgical procedures are usually needed in the majority of cases that undergo pupilloplasty, and they also give visual gain.

Profiles of Occupational Burnout in the Group of Representatives of High-Risk Professions in Poland.

(1) Background: Working in a high-risk profession is associated with taking on a large responsibility and risking loss of health or life. These professions include, among others, air traffic controllers, firefighters, and ECDs. People working in these professions are particularly vulnerable to experiencing high levels of stress and developing professional burnout syndrome. The aim of the conducted research was to assess the external and internal differences in the intensity of occupational burnout dimensions among representatives of high-risk occupations and to distinguish burnout profiles among them. (2) Methods: The total number of participants working in high-risk occupations who took part in the study was N = 1239, including the following job positions: air traffic controllers (n = 107), firefighters (n = 580), and ECDs (n = 558). The respondents completed the following self-report questionnaires: a structured survey and the Link Burnout Questionnaire. The following statistical tests were performed: cluster analysis, analysis of variance, and chi-square test of independence. (3) Results: The highest intensity of burnout dimensions was presented by representatives of ECDs. Profiles reflecting the types of occupational burnout were distinguished. The representatives of air traffic controllers demonstrated the following profiles: 1-low risk of burnout with a component of psychophysical exhaustion; 2-exhausted with a moderate tendency to disappointment; 3-burned out, ineffective, and uninvolved. The profiles of the ECDs were: 4-engaged, with a reduced sense of effectiveness; 5-with a reduced sense of effectiveness; 6-burned out with a low sense of effectiveness. However, the profiles of the firefighters were: 7-not burned out; 8-at risk of burnout; 9-exhausted with a tendency towards disappointment. Individuals representing the various burnout profiles differed in terms of the severity of the dimensions of occupational burnout as well as sociodemographic and work-related characteristics. (4) Conclusions: The process of occupational burnout varies among people in various high-risk occupations and due to sociodemographic characteristics. The internal differentiation of people representing high-risk professions requires different psychological interventions and preventive measures.

Patterns of intimacy crisis resolution and their associations with romantic loneliness in Polish and U.S. young adults.

In Erikson's model of development, intimacy and isolation denote polar outcomes of psychosocial crisis in young adulthood. Drawing on this model, the present study used three-wave longitudinal data to examine patterns of the success and lack of success in the resolution of Eriksonian crisis in relation to romantic loneliness as a negative outcome of the intimacy crisis, and compared across Poland and the United States. The data were collected from Polish and U.S. individuals aged 18-40 for Wave 1 (N = 763). Four patterns of the Eriksonian intimacy crisis were identified: (a) stable partnered status; (b) stable single status; (c) transition from single to partnered status; (d) transition from partnered to single status. In both countries, transition from single to partnered status was related to decreased romantic loneliness. Greater initial romantic loneliness was observed among Polish single adults who transited to partnered status in contrast to stable single adults. In turn, the U.S. partnered adults who transited to single status initially experienced lower romantic loneliness than stable single adults. Bivariate latent growth curve models pairing romantic loneliness with relationship satisfaction revealed that higher initial relationship satisfaction was associated with lower initial romantic loneliness, and a greater increase in relationship satisfaction was associated with smaller increases in romantic loneliness. The findings highlight that different resolutions of the intimacy crisis are related to diverse romantic loneliness and relationship satisfaction trajectories and these associations also appear to differ as a function of various marital and loneliness contexts in Poland and the United States. (PsycInfo Database Record (c) 2022 APA, all rights reserved).

Respiratory involvement in antineutrophil cytoplasmic antibody-associated vasculitides: a retrospective study based on POLVAS registry.

OBJECTIVES: The study aimed to characterise the Polish population of (ANCA)-associated vasculitides (AAV) with respiratory involvement (RI), in comparison to the subgroup without lung manifestations and the other cohorts. METHODS: Retrospective analysis of the Polish population of AAV with RI was conducted, based on data from the POLVAS registry. Standard descriptive statistics, χ2 test, and Mann-Whitney U test were used to perform comparisons. RESULTS: Among 461 cases qualified to this study, there were 316 cases with RI (68.5%), 206 with granulomatosis with polyangiitis (GPA) (65.2%), 80 with eosinophilic granulomatosis with polyangiitis (EGPA) (25.3%) and 30 with microscopic polyangiitis (MPA) (9.5%). Proportion of RI in GPA, MPA, and EGPA accounted for 67.8%; 40.0%; 97.6%, respectively. The number of relapses was higher in the RI group (median 1.0 vs. 0.0; p=0.01). In the subgroup of combined GPA and MPA with RI, the trends toward higher proportion of deaths (11.7% vs. 5.7%; p=0.07), relapses requiring hospitalisation (52.2% vs. 42.4%, p=0.07) and relapses requiring admission to the intensive care unit (5.6% vs. 1.4%, p=0.09) were observed, median maximal concentration of CRP was higher (46 vs. 25 mg/l; p=0.01) and more aggressive treatment was administered. CONCLUSIONS: Prevalence of RI in the Polish population of AAV is similar to the values reported in the literature, however, the proportion observed in GPA is closer to those presented in Asian than Western European cohorts. RI seems to be associated with a more severe course of disease and its presence prompts more aggressive treatment.