Evaluation of salivary transferrin in patients with oral squamous cell carcinoma.

OBJECTIVES: About 94% of oral cancers are squamous cell carcinomas (OSCCs). Its occurrence is age-related due to some factors. Salivary biomarkers have good susceptibility to OSCC's early diagnosis. Moreover, since the clinical diagnosis of advanced stages of OSCC is feasible, its prognosis is very poor. MATERIAL AND METHODS: According to inclusion and exclusion criteria, 40 OSCC patients and 40 healthy people were selected, and 5 mL of saliva were prepared from each person. The quantity of saline transferrin was computed. After that, the data were analyzed. RESULTS: Our study results demonstrated that the mean and standard deviation of the salivary transferrin in the control group were 1.234 mL and 0.374, respectively, and in the case group, it was equal to 2.512 mL for the mean and 0.463 for the standard deviation. There was a statistically substantial difference between the mean of the salivary transferrin variable in the two study groups. CONCLUSION: In conclusion, the mean concentration of salivary transferrin in the case group was higher than in the control group.

Conventional maxillary denture versus maxillary implant-supported overdenture opposing mandibular implant-supported overdenture: Patient's satisfaction.

OBJECTIVES: This study sought to determine the impact of age, gender, and use of maxillary implant-supported overdenture (UISOD) versus conventional denture (CMD) opposing mandibular implant-supported overdenture (LISOD) and the number of years the patient has used their prosthesis on the ratings of satisfaction. This study aimed to assess the long-term influence of different factors on patients' satisfaction with LISODs needing a maxillary prosthesis, helping dentists choose a treatment pathway that leads to a higher satisfaction rate. MATERIAL AND METHODS: This cross-sectional study included 84 participants. They were treated with LISOD opposing either CMD or UISOD from 2015 to 2020. They were all eligible to participate in the study. An oral health impact profile (OHIP-14) questionnaire was given to each patient and filled out by them. OHIP-14 scores were gathered and went under statistical analysis with PASS-11 software to determine the relationship between patients' satisfaction with the scores. RESULTS: Age and gender had no significant influence on how satisfied patients were. Patients with maxillary overdentures showed more satisfaction than the CMD group (p < .05). Moreover, patients' satisfaction decreased with increasing years of prostheses usage (p < .05). CONCLUSIONS: This study demonstrated that satisfaction is related to the type of maxillary prosthesis (conventional or implant-supported) used opposing LISODs and the number of years the patient had used the prostheses.

Evaluation of the serum level of estrogen, progesterone, prolactin, and testosterone in patients with trigeminal neuralgia compared to a healthy population.

OBJECTIVES: The goal of this study is to measure and compare the hormonal serum levels (estrogen, progesterone, testosterone, prolactin, dihydrotestosterone [DHT]) in trigeminal neuroglia (TN) menopausal women and healthy women. MATERIALS AND METHODS: This cross-sectional and case-control study was performed in 2018 and 2019. For this study, menopausal women with confirmed TN were enrolled. Twenty-two healthy women in the control group and 19 in the case group participated. Blood samples were taken from participants for assessment of hormonal serum levels (estrogen, progesterone, testosterone, prolactin, DHT). Data were analyzed by SPSS version 18. Mann-Whitney, T-test, kormography test, nonmetric, χ2  test, and odds ratios have been used. RESULTS: In patients with TN, the serum level of testosterone was significantly higher (p = .036), and the serum level of prolactin (p = .016) was significantly lower. Other evaluated hormones' serum level was identical in the two groups. Patients with abnormal estrogen levels were more in the TN group in comparison with the healthy group. The abnormality of progesterone in TN patients was more in comparison to the healthy control group. CONCLUSIONS: Estrogen and progesterone serum levels in TN patients are higher in comparison with the healthy group, while prolactin and testosterone serum levels are lower in the control group. Moreover, the DHE serum level is similar in both groups.

Prevalence of body dysmorphic disorder in rhinoplasty candidates: A systematic review and meta-analysis.

Background: Body dysmorphic disorder (BDD) is a prevalent mental disorder, particularly in those seeking plastic surgery, leading to unnecessary surgeries and postsurgical dissatisfaction. Among the plastic surgeries, rhinoplasty is the most commonly sought, yet the data on prevalence of BDD among the candidates of rhinoplasty is limited. Therefore, this systematic review and meta-analysis aimed to estimate the prevalence of BDD in rhinoplasty candidates. Methods: The online libraries of Web of Science, PubMed, Cochrane Library, ProQuest, Research Square, Scopus, and Google Scholar were searched up to August 2022. Statistical analyses were performed using STATA software (v. 16). The heterogeneity was determined using the I 2 statistic, and an overall estimated analysis was conducted. Subgroup analyses were performed on study year, age, gender, World Health Organization regional classification, sociodemographic index, country, sample size, and employed diagnostic tool. A meta-regression analysis was performed to identify potential sources of heterogeneity. Results: Out of 12,999 studies assessed, 18, with a combined sample size of 2132 individuals, met our criteria and were included in the study. The pooled prevalence of BDD was 32.7% (95% CI: 23.6-41.7; I 2 = 96.45%). Subgroup analyses revealed the studies that were conducted in the European region (42.8%), with a sample size of ≥100 (40.2%), utilized the BDD modification of the Y-BOCS (BDD-YBOCS) diagnostic method (47.3%), and with a quality score of ≥6 (34.2%) demonstrated higher prevalence of BDD. The meta-regression analysis identified a higher prevalence in the BDD-YBOCS diagnostic method than in the BDD questionnaire (ß: 0.23; 95% CI: 0.04-0.43; p = 0.022). Conclusions: The prevalence of BDD is high in those seeking rhinoplasty. Clinicians should be aware of BDD symptoms to prevent unnecessary surgery and dissatisfaction. Public awareness through the media and access to affordable medical services should also be provided.

A case report of adult Langerhans cell histiocytosis and review of the literature.

Langerhans cell histiocytosis (LCH) is an uncommon proliferative disease with an unknown cause. Its clinical manifestations vary and can involve a variety of organs. To diagnose LCH, radiographs, histopathological and immunohistochemical findings are essential. The gold standard for a definite diagnosis is positive CD1a/CD207 and S100 in the immunohistochemical results. Different treatment plans are available for patients struggling with LCH. To our knowledge, the LCH incidence rate is about 8.9 in one million children and 1-2 cases in one million adults. Our case shows the importance of early diagnosis of this rare condition for the prevention of any further spreading. This case report is about a 35-year-old male patient struggling with diabetes insipidus with a chief complaint of tooth mobility. Based on his X-ray radiographs, osteolytic lesions were found. A biopsy was performed, and due to histopathological and immunohistochemical findings, it was diagnosed as a case of LCH in adults. This paper shows that although the incidence rate of LCH is rare in adults, dealing with a patient struggling with diabetes insipidus and osteolytic bone lesions with an unknown cause, LCH must be taken into consideration. Due to the fact that LCH's first manifestations are mostly first oral, its good prognosis in the early stages, and if it progresses, it can turn fatal, it is important that dentists are aware of this disease, its clinical manifestations, and patient management. In case of suspicion, X-ray examination, biopsy, histopathological, and immunohistochemical exams must be performed.

Rare fibrolipoma of attached gingiva: A case report and review of the literature.

Lipoma is a rare benign tumor. Fibrolipoma, a variant of lipoma, is relatively uncommon in mouth tissues. Among all benign lesions of oral cavity, the approximate incidence rate of lipoma is 1%-4%, with a prevalence rate of about 0.0002%. Fibrolipoma is an extremely rare subtype of lipoma, especially in the attached gingiva. This subtype accounts for 1.6% of all facial lipomas, with a prevalence rate of 1/5000 adults in the oral and oropharyngeal region. It is diagnosed by histopathologic and immunohistochemistry evaluation and treated by total excision. Due to the adhesion to the surrounding tissues and pseudo-infiltrating characteristics of this lesion, it can get mistaken with malignant lesions; therefore, a histological examination is mandatory. In this paper, a case of a patient with attached gingiva fibrolipoma treated by surgical excision is reported. This case report is about a 26-year-old female patient in Shiraz School of Dentistry with a fibrolipoma of attached gingiva. Because of fibrolipoma's growth tendency, adhesion to the surrounding tissues, and specific histological characteristics, its differential diagnosis with malignant infiltrating tumors is important. Surgical excision is the gold standard for treatment. Accurate differential diagnosis, careful histological examination, and periodic follow-up are essential.