[Fibrous hamartoma in childhood. A case description of large size and review of the literature]. / Hamartoma fibroso de la infancia. Descripción de un caso de gran tamaño y revisión de la literatura.

INTRODUCTION: Fibrous hamartoma of infancy is a rare soft tissue tumour that usually appears before 2 years of age, typically in the upper extremities of male infants. CASE REPORT: We report the case of a 2 year old boy with a large and rapidly growing tumour in the upper extremity. COMMENTS: We describe the case, its differential diagnosis and the immunhistological characteristics, and we discuss the non-aggressive surgical treatment, based on the benign behaviour of this tumour.

INTRODUCCION: El hamartoma fibroso de la infancia es un raro tumor de partes blandas, que aparece antes de los 2 años de edad, típicamente en varones, en las extremidades superiores. CASO CLINICO: Presentamos el caso de un niño de 2 años con una gran masa de crecimiento rápido en miembro superior. COMENTARIOS: Se realiza descripción del caso, del diagnóstico diferencial y de sus características inmunohistológicas y se discute el tratamiento quirúrgico no agresivo, basado en el comportamiento benigno del tumor.

Hamartoma fibroso de la infancia. descripción de un caso de gran tamaño y revisión de la literatura / Fibrous hamartoma in childhood. A case description of large size and review of the literature

Introducción. El hamartoma fibroso de la infancia es un raro tumor de partes blandas, que aparece antes de los 2 años de edad, típicamente en varones, en las extremidades superiores. Caso clínico. Presentamos el caso de un niño de 2 años con una gran masa de crecimiento rápido en miembro superior. Comentarios. Se realiza descripción del caso, del diagnóstico diferencial y de sus características inmunohistológicas y se discute el tratamiento quirúrgico no agresivo, basado en el comportamiento benigno del tumor (AU)

Introduction. Fibrous hamartoma of infancy is a rare soft tissue tumour that usually appears before 2 years of age, typically in the upper extremities of male infants. Case report. We report the case of a 2 year old boy with a large and rapidly growing tumour in the upper extremity. Comments. We describe the case, its differential diagnosis and the immunhistological characteristics, and we discuss the non-aggressive surgical treatment, based on the benign behaviour of this tumour (AU)

Evaluation of sorption, solubility and staining of universal and silorane resin-based composites.

Resin-based composite staining is a multifactoral phenomenon and can be caused by intrinsic and extrinsic factors. The purpose of this study was to compare staining, sorption and solubility of silorane resin-based and universal resin-based composites. Five different resin-based composites (4 Seasons, Charisma, Filtek Silorane, Filtek Supreme and Grandio) were tested. Twenty five specimens were prepared (10 mm diameter and 1.5 mm thick). To staining test, the specimens were divided into 3 groups (n = 5): distilled water (control), coffee and red wine. The specimens were immersed in one of the solutions at 37 degrees C for 7 days. Using the values of L*, a*, b*, color variation (CIEDE2000) was determined. For sorption and solubility test, the specimens were divided into 2 groups (n = 5): with previous desiccation (Group 1) and with no previous desiccation (Group 2). The methodology used for sorption and solubility test was based on ISO 4049:2000. The results presented no significant difference in staining between composites. In sorption and solubility test, Filtek Silorane presented the smallest values, followed by Grandio. Under tested experimental conditions, it is not possible to assert the dependence of staining in sorption that composites are undergone. There was no significant correlation between colour change and sorption values.

Antigenicity, cross-reactivity and surface exposure of the Neisseria meningitidis 37 kDa protein (Fbp).

The 37 kDa iron-repressible protein, Fbp, was purified from two Neisseria meningitidis strains by metal-affinity chromatography and used to obtain mouse monospecific polyclonal immune sera. Dot-blot, immunoblotting and whole cell ELISA results demonstrate that the Fbp is present in all 16 N. meningitidis and four commensal Neisseria species tested, is highly antigenic in mouse when injected in pure form, and shows intra- and inter-species antigenic homogeneity, anti-Fbp antibodies being fully cross-reactive using the techniques mentioned. We also found that Fbp molecules (or parts of them) are surface exposed, in disagreement with the proposed exclusively periplasmic localization, although anti-Fbp antibodies seem unable to block iron uptake or to induce complement-mediated killing of the meningococci. Taken along with the high immunogenicity of the purified protein and the complete cross-reactivity of the antibodies elicited, this suggests that the protective effect of the purified Fbp must be further studied to evaluate its inclusion in future vaccine trials.