ANALYSIS OF CLINICAL AND LABORATORY PARAMETERS CHILDREN WITH DIABETES MELLIUS TYPE 1 USING DIFFERENT TYPES OF INSULIN PREPARATIONS.

A comparative analysis of clinical and laboratory parameters was carried out in 49 children. The patients were divided into 3 groups depending on the type of insulin they received. Group 1 included 20 children who used Insulin human (Insulatard), group 2 included 15 children using insulin Glargine, and group 3 included 14 children using insulin Detemir. All children using Detemir and Glargine used short acting insulin Aspart. Those using Insulin human (Insulatard) used Human insulin (rDNA, Actrapid) in addition. In all children, blood glucose, glycohemoglobin and cholesterol were determined by laboratory methods. Statistical calculations were carried out using a statistical package at a confidence level of p＜0.05. A significant difference was found between the mean values of glycohemoglobin and glucose of Glargine users and patients with using Insulin human (Insulatard) (p≺0.05). These indicators were lower in Glargine users. There is a positive correlation between doses of Regular insulin and Insulin human (Insulatard) with body weight and height. There is a positive correlation between dose of Detemir and body mass. However, no such relationship between Glargine, body mass and height was recorded. It was a negative correlation between its dose Glargine with glycohemoglobin and also between glucose and cholesterol using Glargine.

Gamma ray detection performance of newly developed MAPD-3NM-II photosensor with LaBr3(Ce) crystal.

This paper presents the gamma-ray detection performance of the newly developed MAPD-3NM-II type SiPM sensor array (4 [Formula: see text] 4) with [Formula: see text](Ce) scintillator. The gamma-ray spectra of various sources have been measured in the energy range from 26 keV up to 1332 keV. The newly developed array based on MAPD-3NM-II sensors proved [Formula: see text] 22% enhancement in energy resolution in comparison to the former MAPD-3NM-I based array. The energy resolution of 662 keV gamma-rays measured by MAPD-3NM-II was 3.3% while clearly surpassing 4.25% resolution of MAPD-3NM-I predecessor. The enhancement is related to the high PDE of the new MAPD-3NM-II. Obtained results show that the new MAPD-3NM-II demonstrated good energy resolution and linearity in the studied energy region. The energy resolution of the new detector developed based on MAPD-3NM-II was better than all previous products of MAPD.

[STUDY OF THE PTPN22 GENE IN CHILDREN WITH TYPE 1 DIABETES MELLITUS IN THE AZERBAIJANI POPULATION].

The PTPN22 gene was studied in 160 children with type 1 diabetes mellitus under the age of 18 years and in 271 healthy children. Of the 160 patients, 50.6% (n=81) were boys, 49.4% (n=79) were girls. The average age of diabetic children was 9.1 years. The survey was conducted on the basis of the Children's Clinical Hospital No. 6 in Baku city. For all patients, a special questionnaire was filled out. Only children of Azerbaijani nationality were included in the study. As a comparison group, 271 students of the Medical College No. 1 of Baku city were involved. Of these, 29.1% (n=79) were boys, 70.9% (n = 192) girls. The control group did not include children with endocrine diseases. The collected blood samples were sent for further investigation to the medical genetic laboratory of the University Hospital of Motol at Charles University, located in the city of Prague (Czech Republic). This laboratory has a European certificate for conducting molecular genetic studies. In the Azerbaijani population, 3 polymorphisms of the PTPN22 gene were studied: 1123 (rs2488457), +1848 (rs2476601, or R620W), +2740 (rs1217412). Relationship with insulin-dependent diabetes mellitus was found only in polymorphism R620W. In this case, a minor allele (W) was found in 8 (5%) patients with diabetes mellitus and only 2 (0.74%) of healthy children, which is a reliable result (OR 7.1, 95% CI = 1.5 -34). Polymorphisms -1123 C/G and +2740 A/G showed no correlation with diabetes mellitus. The Azerbaijani population has higher odds ratios for haplotypes-1123C W620 + 2740G (OR 14.8, 95% CI=2.0-651). No inter-sex correlation was observed in the examined. At the same time, the trend was also not revealed.