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Developing cost-effective and high-performance catalyst systems for dry reforming of methane (DRM) is crucial for producing hydrogen (H2) sustainably. Herein, we investigate using iron (Fe) as a promoter and major alumina support in Ni-based catalysts to improve their DRM performance. The addition of iron as a promotor was found to add reducible iron species along with reducible NiO species, enhance the basicity and induce the deposition of oxidizable carbon. By incorporating 1 wt.% Fe into a 5Ni/10ZrAl catalyst, a higher CO2 interaction and formation of reducible "NiO-species having strong interaction with support" was observed, which led to an â¼80% H2 yield in 420 min of Time on Stream (TOS). Further increasing the Fe content to 2wt% led to the formation of additional reducible iron oxide species and a noticeable rise in H2 yield up to 84%. Despite the severe weight loss on Fe-promoted catalysts, high H2 yield was maintained due to the proper balance between the rate of CH4 decomposition and the rate of carbon deposit diffusion. Finally, incorporating 3 wt.% Fe into the 5Ni/10ZrAl catalyst resulted in the highest CO2 interaction, wide presence of reducible NiO-species, minimum graphitic deposit and an 87% H2 yield. Our findings suggest that iron-promoted zirconia-alumina-supported Ni catalysts can be a cheap and excellent catalytic system for H2 production via DRM.
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Óxido de Aluminio , Hidrógeno , Hierro , Metano , Níquel , Circonio , Metano/química , Circonio/química , Catálisis , Hierro/química , Hidrógeno/química , Óxido de Aluminio/química , Níquel/químicaRESUMEN
MXene-based architectures have paved the way in various fields, particularly in healthcare area, owing to their remarkable physiochemical and electromagnetic characteristics. Moreover, the modification of MXene structures and their combination with polymeric networks have gained considerable prominence to further develop their features. The combination of electrospun fibers with MXenes would be promising in this regard since electrospinning is a well-established technique that is now being directed toward commercial biomedical applications. The introduction of MXenes into electrospun fibrous frameworks has highlighted outcomes in various biomedical applications, including cancer therapy, controlled drug delivery, antimicrobial targets, sensors, and tissue engineering. Correspondingly, this review describes the employed strategies for the preparation of electrospun configurations in tandem with MXene nanostructures with remarkable characteristics. Next, the advantages of MXene-decorated electrospun fibers for use in biomedical applications are comprehensively discussed. According to the investigations, rich surface functional groups, hydrophilicity, large surface area, photothermal features, and antimicrobial and antibacterial activities of MXenes could synergize the performance of electrospun layers to engineer versatile biomedical targets. Moreover, the future of this path is clarified to combat the challenges related to the electrospun fibers decorated with MXene nanosheets.
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Introduction: An effective referral system is necessary to ensure quality and an optimum continuum of care. In the Kingdom of Saudi Arabia, an e-referral system known as the Saudi Medical Appointments and Referrals Centre (SMARC), has been fully functioning since 2019. This study aims to explore the rate of medical e-referral request acceptance in the KSA, and to study the factors associated with acceptance. Methods: This period cross-sectional study utilised secondary collected data from the SMARC e-referral system. The data spans both 2020 and 2021 and covers the entirety of the KSA. Bivariate analyses and binary logistic regression analyses were performed to compute adjusted Odds Ratios (aORs) and 95% confidence intervals. Results: Of the total 632,763 referral requests across the 2 years, 469,073 requests (74.13%) were accepted. Absence of available machinery was a significant predictor for referral acceptance compared to other reasons. Acceptance was highest for children under 14 with 28,956 (75.48%) and 63,979 (75.48%) accepted referrals, respectively. Patients requiring critical care from all age groups also had the highest acceptance including 6,237 referrals for paediatric intensive care unit (83.54%) and 34,126 referrals for intensive care unit (79.65%). All lifesaving referrals, 42,087 referrals, were accepted (100.00%). Psychiatric patients were observed to have the highest proportion for accepted referrals with 8,170 requests (82.50%) followed by organ transplantations with 1,005 requests (80.92%). Sex was seen to be a significant predictor for referrals, where the odds of acceptances for females increased by 2% compared to their male counterparts (95% CI = 1.01-1.04). Also, proportion of acceptance was highest for the Eastern business unit compared to all other units. External referrals were 32% less likely to be accepted than internal referrals (95% CI = 0.67-0.69). Conclusion: The current findings indicate that the e-referral system is mostly able to cater to the health services of the most vulnerable of patients. However, there remains areas for health policy improvement, especially in terms of resource allocation.
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Derivación y Consulta , Humanos , Arabia Saudita , Derivación y Consulta/estadística & datos numéricos , Estudios Transversales , Masculino , Femenino , Adulto , Persona de Mediana Edad , Adolescente , Niño , Preescolar , Bases de Datos Factuales , Adulto Joven , Lactante , Aceptación de la Atención de Salud/estadística & datos numéricos , AncianoRESUMEN
Leveraging date palm spikelets (DPS) as a precursor, this study developed a DPS-derived composite (ZnO@DPS-AC) for water treatment, focusing on methyl orange (MO) removal. The composite was synthesized through ZnCl2 activation and pyrolysis at 600 °C. Comprehensive characterization was conducted using TGA, FTIR, XRD, SEM/EDS, and pHPZC. Characterization revealed a highly carbonaceous material (> 74% carbon) with significant porosity and surface functional groups. ZnO@DPS-AC demonstrated rapid MO removal, achieving over 45% reduction within 10 min and up to 99% efficiency under optimized conditions. The Langmuir model-calculated maximum adsorption capacity reached 226.81 mg/g at 20 °C. Adsorption mechanisms involved hydrogen bonding, π-π interactions, and pore filling. The composite showed effectiveness in treating real wastewater and removing other pollutants. This study highlights the potential of agricultural waste valorization in developing efficient, sustainable adsorbents for water remediation, contributing to circular bioeconomy principles.
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INTRODUCTION: There is a rising concern about developing innovative, efficacious PDE5I molecules that provide better safety, efficacy, and tolerability with less adverse effects. Innovative PDE5I with dual targets have also been defined in the literature. Additionally, some of PDE5I are able to selectively inhibit other enzymes such as histone deacetylase, acetylcholine esterase, and cyclooxygenase or act as nitric oxide donors. This review presents knowledge concerning the advanced trends and perspectives in using PDE5I in treatment of ED and other conditions. AREAS COVERED: Pre-clinical and early clinical trials that investigated the safety, efficacy, and tolerability of novel PDE5I such as Udenafil, Mirodenafil, Lodenafil, Youkenafil, Celecoxib, and TPN729 in treatment of ED and other conditions. EXPERT OPINION: Preclinical and limited early clinical studies of the new molecules of PDE5I have demonstrated encouraging results; however, safety, efficacy, and tolerability are still issues that necessitate further long-term multicenter clinical studies to ensure justification of their uses in treatment of ED and other conditions. Progress in molecular delivery techniques and tailored patient-specific management and additional therapeutic technology will dramatically improve care for ED and other conditions. The dream of ED and many other conditions becoming more effectively managed may be feasible in the near future.
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The escalating environmental crisis posed by single-use plastics underscores the urgent need for sustainable alternatives. This study provides an approach to introduce biodegradable polymer blends by blending synthetic polyvinyl alcohol (PVA) with natural polymers-corn starch (CS) and hydroxypropyl methylcellulose (HPMC)-to address this challenge. Through a comprehensive analysis, including of the structure, mechanical strength, water solubility, biodegradability, and thermal properties, we investigated the enhanced performance of PVA-CS and PVA-HPMC blends over conventional polymers. Scanning electron microscopy (SEM) findings of pure PVA and its blends were studied, and we found a complete homogeneity between the PVA and both types of natural polymers in the case of a high concentration of PVA, whereas at lower concentration of PVA, some granules of CS and HMPC appear in the SEM. Blending corn starch (CS) with PVA significantly boosts its biodegradability in soil environments, since adding starch of 50 w/w duplicates the rate of PVA biodegradation. Incorporating hydroxypropyl methylcellulose (HPMC) with PVA not only improves water solubility but also enhances biodegradation rates, as the addition of HPMC increases the biodegradation of pure PVA from 10 to 100% and raises the water solubility from 80 to 100%, highlighting the significant acceleration of the biodegradation process and water solubility caused by HPMC addition, making these blends suitable for a wide range of applications, from packaging and agricultural films to biomedical engineering. The thermal properties of pure PVA and its blends with natural were studied using diffraction scanning calorimetry (DSC). It is found that the glass transition temperature (Tg) increases after adding natural polymers to PVA, referring to an improvement in the molecular weight and intermolecular interactions between blend molecules. Moreover, the amorphous structure of natural polymers makes the melting temperature ™ lessen after adding natural polymer, so the blends require lower temperature to remelt and be recycled again. For the mechanical properties, both types of natural polymer decrease the tensile strength and elongation at break, which overall weakens the mechanical properties of PVA. Our findings offer a promising pathway for the development of environmentally friendly polymers that do not compromise on performance, marking a significant step forward in polymer science's contribution to sustainability. This work presents detailed experimental and theoretical insights into novel polymerization methods and the utilization of biological strategies for advanced material design.
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Global warming, driven by greenhouse gases like CH4 and CO2, necessitates efficient catalytic conversion to syngas. Herein, Ni containing different molecular sieve nanomaterials are investigated for dry reforming of methane (DRM). The reduced catalysts are characterized by surface area porosity, X-ray diffraction, Raman infrared spectroscopy, CO2 temperature-programmed desorption techniques, and transmission electron microscopy. The active sites over each molecular sieve remain stable under oxidizing gas CO2 during DRM. The reduced 5Ni/CBV10A catalyst, characterized by the lowest silica-alumina ratio, smallest surface area and pore volume, and narrow 8-ring connecting channels, generated the maximum number of active sites on its outer surface. In contrast, the reduced-5Ni/CBV3024E catalyst, with the highest silica-alumina ratio, more than double the surface area and pore volume, 12-ring sinusoidal porous channels, and smallest Ni crystallite, produced the highest H2 output (44%) after 300 min of operation at 700 °C, with a CH4:CO2 = 1:1, P = 1 atom, gas hour space velocity (GHSV) = 42 L gcat-1 h-1. This performance was achieved despite having 25% fewer initial active sites, suggesting that a larger fraction of these sites is stabilized within the pore channels, leading to sustained catalytic activity. Using central composite design and response surface methodology, we successfully optimized the process conditions for the 5Ni/CBV3024E catalyst. The optimized conditions yielded a desirable H2 to CO ratio of 1.00, with a H2 yield of 91.92% and a CO yield of 89.16%, indicating high efficiency in gas production. The experimental results closely aligned with the predicted values, demonstrating the effectiveness of the optimization approach.
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Colorectal cancer (CRC) being one of the most common malignancies, has a significant death rate, especially when detected at an advanced stage. In most cases, the fundamental aetiology of CRC remains unclear despite the identification of several environmental and intrinsic risk factors. Numerous investigations, particularly in the last ten years, have indicated the involvement of epigenetic variables in this type of cancer. The development, progression, and metastasis of CRC are influenced by long non-coding RNAs (lncRNAs), which are significant players in the epigenetic pathways. LncRNAs are implicated in diverse pathological processes in CRC, such as liver metastasis, epithelial to mesenchymal transition (EMT), inflammation, and chemo-/radioresistance. It has recently been determined that CRC cells and tissues exhibit dysregulation of tens of oncogenic and tumor suppressor lncRNAs. Serum samples from CRC patients exhibit dysregulated expressions of several of these transcripts, offering a non-invasive method of detecting this kind of cancer. In this review, we outlined the typical paradigms of the deregulated lncRNA which exert significant role in the underlying molecular mechanisms of CRC initiation and progression. We comprehensively discuss the role of lncRNAs as innovative targets for CRC prognosis and treatment.
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Behçet's Disease (BD) is an intricate medical puzzle, captivating researchers with its enigmatic pathogenesis. This complex ailment, distinguished by recurrent mouth and genital lesions, eye irritation, and skin injuries, presents a substantial obstacle to therapeutic research. This review explores the complex interaction of microRNAs (miRNAs) with BD, highlighting their crucial involvement in the disease's pathophysiology. miRNAs, recognized for regulatory influence in diverse biological processes, hold a pivotal position in the molecular mechanisms of autoimmune diseases, such as BD. The exploration begins with examining miRNA biogenic pathways and functions, establishing a foundational understanding of their regulatory mechanisms. Shifting to the molecular landscape governing BD, the review highlights miRNA-mediated impacts on critical signaling pathways like Notch, nuclear factor kappa-light-chain-enhancer of activated B cells (NF-κB), and protein kinase B (AKT)/mammalian target of rapamycin (mTOR), offering insights into intricate pathophysiological mechanisms. Dissecting the immunological landscape reveals the profound influence of miRNAs on BD, shedding light on the intricate modulation of immune responses and offering novel perspectives on disease etiology and progression. Beyond molecular intricacies, the review explores the clinical relevance of miRNAs in BD, emphasizing their potential as diagnostic and prognostic indicators. The discussion extends to the promising realm of miRNA-based therapeutic interventions, highlighting their potential in alleviating symptoms and altering disease progression. This comprehensive review, serving as a valuable resource for researchers, clinicians, and stakeholders, aims to decipher the intricate molecular tapestry of BD and explore the therapeutic potential of miRNAs.
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BACKGROUND: Osteoporosis is a prevalent metabolic bone disease in the Middle East. Middle Easterners rely on the Internet as a source of information about osteoporosis and its treatment. Adequate awareness can help to prevent osteoporosis and its complications. Websites covering osteoporosis in Arabic must be of good quality and readability to be beneficial for people in the Middle East. METHODS: Two Arabic terms for osteoporosis were searched on Google.com (Google Inc., Mountainview, CA), and the first 100 results for each term were examined for eligibility. Two independent raters evaluated the websites using DISCERN and the Journal of the American Medical Association (JAMA) criteria for quality and reliability. The Flesch Kincaid grade level (FKGL), Simple Measure of Gobbledygook (SMOG), and Flesch Reading Ease (FRE) scale were used to evaluate the readability of each website's content. RESULTS: Twenty-five websites were included and evaluated in our study. The average DISCERN score was 28.36±12.18 out of 80 possible scores. The average JAMA score was 1.05±1.15 out of four total scores. The readability scores of all websites were, on average, 50.71±21.96 on the FRE scale, 9.25±4.89 on the FKGL, and 9.74±2.94 on the SMOG. There was a significant difference (p = 0.026 and 0.044) in the DISCERN and JAMA scores, respectively, between the websites on the first Google page and the websites seen on later pages. CONCLUSION: The study found Arabic websites covering osteoporosis to be of low quality and difficult readability. Because these websites are a major source for patient education, improving their quality and readability is a must. The use of simpler language is needed, as is covering more aspects of the diseases, such as prevention.
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Harmful elements in Egyptian phosphoric acid were identified by radiochemical neutron activation analysis. In the Second Egyptian Nuclear Research Reactor, precipitates were created and examined to identify many types of contaminants (Ce, Co, Cr, etc.). New bionanocomposite materials effectively removed with a high proportion each of Ce, Th, Pa, U, Np, Zn, and Co (100%) and a somewhat lower percentage (65-85%) for Cr, Sc, and Fe from simulated solutions, suggesting promise for purifying phosphoric acid.
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INTRODUCTION: It has long been understood that sleep is a necessary therapeutic element of human physiology and is crucial for healthy functioning, mental health, and quality of life. Medical students frequently minimize their sleep and habits to cope with their workload and their stressful lives, which has a negative influence on both mental health and academic performance. The purpose of this study was to evaluate the prevalence of stress and its effect on sleep quality among medical students (in both the preclinical and clinical years) at Jazan University in Saudi Arabia. MATERIALS AND METHODS: A cross-sectional research design was applied in this study. The sample constituted medical students at Jazan University, Jazan region, Saudi Arabia. A self-administered online survey was distributed actively to measure the variables of interest. RESULTS: This study examined the sleep quality and psychological distress among 347 students. The findings revealed that a significant proportion of students experienced sleep difficulties, with 52.8% reporting mild sleep problems and 46.6% reporting moderate sleep difficulties. In addition, a notable percentage of participants (28.2%) reported very high psychological distress, while 27.4% experienced severe psychological distress. CONCLUSIONS: This study found that medical students had a high level of stress and poor sleep quality, which led to unhealthy habits, such as consuming many energy drinks. Hence, it is recommended that concerns should be addressed to minimize the risk of developing chronic illnesses.
Résumé Introduction:Il est depuis longtemps admis que le sommeil est un élément thérapeutique essentiel de la physiologie humaine et qu'il est crucial pour un fonctionnement sain, la santé mentale et la qualité de vie. Les étudiants en médecine ont souvent tendance à réduire leur sommeil et à modifier leurs habitudes pour faire face à leur charge de travail et à leur vie stressante, ce qui a une influence négative sur leur santé mentale et leurs performances académiques. L'objectif de cette étude était d'évaluer la prévalence du stress et son effet sur la qualité du sommeil chez les étudiants en médecine (tant en années précliniques que cliniques) à l'Université de Jazan en Arabie saouditeMatériel et méthodes:Une étude transversale a été réalisée dans le cadre de cette étude. L'échantillon était constitué d'étudiants en médecine de l'Université de Jazan, dans la région de Jazan, en Arabie saoudite. Une enquête en ligne auto-administrée a été activement distribuée pour mesurer les variables d'intérêt.Résultats:Cette étude a examiné la qualité du sommeil et la détresse psychologique chez 347 étudiants. Les résultats ont révélé qu'une proportion significative d'étudiants rencontrait des difficultés de sommeil, avec 52,8 % signalant des problèmes de sommeil légers et 46,6 % signalant des difficultés de sommeil modérées. De plus, un pourcentage notable de participants (28,2 %) a signalé une détresse psychologique très élevée, tandis que 27,4 % ont connu une détresse psychologique sévèreConclusions:Cette étude a révélé que les étudiants en médecine présentaient un niveau élevé de stress et une mauvaise qualité de sommeil, ce qui conduisait à des habitudes peu saines, telles que la consommation excessive de boissons énergisantes. Par conséquent, il est recommandé de prendre des mesures pour réduire le risque de développer des maladies chroniques.
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While isolated internal iliac artery aneurysms (IIIAAs) are rare entities, they are associated with a high mortality rate if ruptured. IIAAs are usually asymptomatic and can be discovered accidentally during imaging for any other causes. The treatment options vary according to the signs, symptoms, size of the aneurysm, and the patient's general condition. While surgery used to be the first option of treatment earlier, with the advances in the field of endovascular intervention, endovascular repair of IIIAA has emerged as the first option of treatment if applicable.
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For the first time, Frankincense resin (FR) has been carboxymethylated to produce CMFR - AuNPs and the conjugate was utilized for the Doxorubicin drug loading. The carboxymethylation of the carboxylic, phenolic, and hydroxyl functional groups of FR has been developed into carboxymethylated Frankincense resin (CMFR). A novel CMFR-AuNPs was synthesized using the developed CMFR as a stabilizing and reducing agent. The antibacterial, antioxidant, and in-vitro anticancer activities were investigated by using CMFR-AuNPs and CMFR - AuNPs@DOX. CMFR-AuNPs demonstrated antioxidative properties by quenching DPPH radicals effectively. CMFR-AuNPs and DOX@CMFR-AuNPs demonstrated strong antibacterial activity against K. pneumoniae, S. aureus, B. subtilis, and E. coli. The cell viability was tested for CMFR -AuNPs at various concentrations of Dox-loaded CMFR -AuNPs (CMFR-AuNPs + Dox1, CMFR-AuNPs + Dox 2, & CMFR-AuNPs + Dox 3). The highest inhibition was observed on MCF-7 and HeLa cell lines using CMFR-AuNPs + Dox 3, respectively. Various techniques such as UV, FTIR, TGA, XRD, SEM, EDAX and TEM were used to characterize the designed CMFR and CMFR-AuNPs. After carboxy methylation, the amorphous nature of FR changed to crystallinity, as reflected in the XRD spectra. The XRD spectrum of the CMFR- AuNPs showed FCC structure due to the involvement of hydroxyl and carboxylic functional groups of CMFR strongly bound with the AuNPs. TGA results revealed that the CMFR is thermally more stable than FR. TEM revealed that CMFR - AuNPs were well dispersed, spherical, and hexagonal with an average diameter of 7 to 10 nm, while the size of doxorubicin loaded (DOX@CMFR-AuNPs) AuNPs was 11 to 13 nm. Green CMFR-AuNPs have the potential to enhance the drug loading and anticancer efficacy of drugs.
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PMMA/PEG and PMMA/PEG doped with SiO2, TiO2, and Al2O3 were fabricated using the solution-casting technique. The composites were characterized by X-ray diffraction and scanning electron microscopy (FE-SEM), which revealed that the amorphous nature of PMMA/PEG blend doped with Al2O3 was hindered by the crystalline nature of those doped with SiO2 and TiO2. The absorption of PMMA/PEG blend doped with Al2O3 is higher, band gap energies were decreased from 4.90 eV for PMMA/PEG blend to 4.03 eV, 3.09 eV, and 2.09 eV for SiO2, TiO2, and Al2O3 doped PMMA/PEG blend, respectively. The dielectric constant, ε' has a high value (2 × 104) for samples PMMA/PEG and SiO2/PMMA/PEG. While dielectric loss ε â³ -values decreased to < 100 for TiO2/PMMA/PEG and Al2O3/PMMA/PEG. Further, the fabricated composite SiO2/PMMA/PEG led to improvement the optical and dielectric properties compared with PMMA/PEG for optoelectronic such as manufacturing of optical fiber cables application. The results show TiO2/PMMA/PEG and Al2O3/PMMA/PEG are multifunctional can be used as low-permittivity nanodielectric and substrates to design the next generation of flexible electronic devices.
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PURPOSE OF REVIEW: Diabetic neuropathy is a common complication of diabetes mellitus (DM) and can affect up to 50% of DM patients during their lifetime. Patients typically present with numbness, tingling, pain, and loss of sensation in the extremities. Since there is no treatment targeting the underlying mechanism of neuropathy, strategies focus on preventative care and pain management. RECENT FINDINGS: Up to 69% of patients with diabetic neuropathy receive pharmacological treatment for neuropathic pain. The United States Food and Drug Administration (FDA) confirmed four drugs for painful diabetic neuropathy (PDN): pregabalin, duloxetine, tapentadol, and the 8% capsaicin patch. Nonpharmacological treatments such as spinal cord stimulation (SCS) and transcutaneous electrical nerve stimulation (TENS) both show promise in reducing pain in DM patients. Despite the high burden associated with PDN, effective management remains challenging. This update covers the background and management of diabetic neuropathy, including its epidemiology, pathogenesis, preventative care, and current therapeutic strategies.
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Anticuerpos Monoclonales Humanizados , Sarcoidosis , Humanos , Anticuerpos Monoclonales Humanizados/efectos adversos , Anticuerpos Monoclonales Humanizados/uso terapéutico , Sarcoidosis/inducido químicamente , Sarcoidosis/tratamiento farmacológico , Antineoplásicos Inmunológicos/efectos adversos , Masculino , Femenino , Persona de Mediana Edad , Melanoma/tratamiento farmacológico , AncianoRESUMEN
Herein, we introduce an innovative nanohybrid material for advanced wastewater treatment, composed of Corchorus olitorius-derived biochar and bismuth oxychloride (Biochar/Bi12O17Cl2), demonstrated in a solar photoreactor. This work focuses on the efficient degradation of linezolid (LIN), a persistent pharmaceutical pollutant, utilizing the unique (photo)catalytic capabilities of the nanohybrid. Compared with its individual components, the biochar/Bi12O17Cl2 hybrid exhibits a remarkable degradation efficiency of 82.6% for LIN, alongside significant chemical oxygen demand (COD) and total organic carbon (TOC) mineralization rates of 81.3 and 75.8%, respectively. These results were achieved within 3 h under solar irradiation, using an optimal composite dose of 125 mg/L at pH 4.3 ± 0.45, with an initial COD and LIN concentrations of 1605 and 160.8 mg/L and TOC of 594.3 mg/L. The nanohybrid's stability across five cycles of use demonstrates its potential for repeated applications, with degradation efficiencies of 82.6 and 77.9% in the first and fifth cycles, respectively. This indicates the biochar/Bi12O17Cl2 composite's suitability as a sustainable and cost-effective solution for the remediation of heavily contaminated waters. Further, the degradation pathway proposed the degradation of all of the generated intermediates to a single-ring compound. Contributing to the development of next-generation materials for environmental remediation, this research underscores the critical role of nanotechnology in enhancing water quality and ecosystem sustainability and addressing the global imperative for clean water access and environmental preservation.
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Rhabdomyolysis involves significant skeletal muscle injury and destruction, which can be triggered by trauma, intense physical activity, heat, prolonged immobility, certain medications, and endocrine disorders. Rhabdomyolysis in renal transplants can be more complicated, and the prognosis is not well known, especially in the context of coexisting rejection. We present a case of rifampicin-induced rhabdomyolysis with superimposed acute cellular rejection in a kidney transplant patient.
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Some heterocycles bearing a benzo[h]quinoline moiety were synthesized through treating a 3-((2-chlorobenzo[h]quinolin-3-yl)methylene)-5-(p-tolyl)furan-2(3H)-one with four nitrogen nucleophiles comprising ammonium acetate, benzylamine, dodecan-1-amine, and 1,2-diaminoethane. Also, thiation reactions of furanone and pyrrolinone derivatives were investigated. The insecticidal activity of these compounds against mosquito larvae (Culex pipiens L.) was evaluated. All tested compounds exhibited significant larvicidal activity, surpassing that of the conventional insecticide chlorpyrifos. In silico docking analysis revealed that these compounds may act as acetyl cholinesterase (AChE) inhibitors, potentially explaining their larvicidal effect. Additionally, interactions with other neuroreceptors, such as nicotinic acetylcholine receptor and sodium channel voltage-gated alpha subunit were also predicted. The results obtained from this study reflected the potential of benzo[h]quinoline derivatives as promising candidates for developing more effective and sustainable mosquito control strategies. The ADME (absorption, distribution, metabolism, and excretion) analyses displayed their desirable drug-likeness and oral bioavailability properties.