Early intervention of extracorporeal photopheresis for advancing/progressing cutaneous T-cell lymphoma.

Patients with cutaneous T-cell lymphoma with progressive disease typically undergo a series of skin-directed and systemic therapy regimens during cycles of response and relapse. Extracorporeal photopheresis (ECP) is an effective and safe systemic treatment option, often reserved for later stages of disease and typically employed after failure of several other therapies. ECP has benefits in response rate, time to next treatment, and tolerability that may support its use earlier in the treatment cycle for advancing/progressing disease.

Metodologias da pesquisa em dança no estado do Rio Grande do Sul: perspectivas ligadas à criação / Research methodologies on dance in the state of Rio Grande do Sul: perspectives linked to creation / Metodologías de investigación sobre la danza en el estado de Rio Grande do Sul: perspectivas vinculadas a la creación

Este artigo apresenta uma metanálise qualitativa de trabalhos de conclusão de curso (TCCs) das graduações em Dança das universidades federais do estado do Rio Grande do Sul. O objetivo central foi compreender quais foram as estratégias metodológicas mais utilizadas nos TCCs, e o quanto suas temáticas investem na criação em Dança. O corpus de análise desta investigação compreendeu um total de 73 trabalhos, e resultou em três ideias-síntese: todo TCC compreende em si mesmo uma metodologia de criação em Dança; tendência às bricolagens e o artista--pesquisador como um bricoleur de experiências formativas; inclinação etnosomática da pesquisa em Dança. O texto se conclui em tensionamentos entre o domínio da palavra escrita na pesquisa em práticas artísticas e o campo da Dança (AU).

This article presents a qualitative meta-analysis of undergraduate final papers from Dance undergraduate courses of federal universities in the state of Rio Grande do Sul/Brazil. The main objective was to understand which were the most used methodological strategies in these final papers, when their themes invested in Dance creation. The corpus of analysis of this investigation comprised a total of 73 undergraduate final papers and resulted in three synthesis-ideas: every undergraduate final paper comprises in itself a methodology of Dance creation; tendency towards bricolage and the artist-researcher as a bricoleur of formative experiences; ethno-somatic inclination of Dance research. The text concludes itself in tensions between the domain of the written word in research on artistic practices and the field of Dance (AU).

Este artículo presenta un metanálisis cualitativo de los trabajos de conclusión de curso de las graduaciones en Danza de las universidades federales del estado de Rio Grande do Sul, Brasil. El objetivo principal fue comprender cuáles fueron las estrategias metodológicas más utilizadas en los TCCs, cuando sus temáticas invierten en la creación en Danza. El corpus de análisis de esta investigación comprendió un total de 73 trabajos, y dio como resultado tres ideas de síntesis: cada TCC comprende en sí mismo una metodología de creación en Danza; tendencia al bricolaje y el artista-investigador como bricoleur de experiencias formativas; inclinación etnosomática de la investigación de la Danza. El texto concluye en tensiones entre el dominio de la palabra escrita en la investigación sobre prácticas artísticas y el campo de la Danza (AU).

Novel Use of Topical Ivermectin for the Prevention of Facial Insect Bites.

Options to prevent facial insect bites while sleeping are limited. Patients may prefer to avoid facial application of potentially neurotoxic insect repellants. Non-toxic “natural” repellants have limited efficacy, and netting may not be well-tolerated. Nightly facial application of 1% topical ivermectin (IVM) cream completely prevented overnight bites in 2 patients, both of whom reported recurrent bites after discontinuation, and a return to complete bite prevention after IVM resumption. Topical IVM may be an alternative facial mosquito bite prevention modality. J Drugs Dermatol. 2022;21(8):906-907. doi:10.36849/JDD.6432.

Hyaluronic acid carrier-based photodynamic therapy for head and neck squamous cell carcinoma.

PURPOSE: Conventional photosensitizers for photodynamic therapy (PDT) typically have wide tissue distribution and poor water solubility. A hyaluronic acid (HA) polymeric nanoparticle with specific lymphatic uptake and highly water solubility was developed to deliver pyropheophorbide-a (PPa) for locally advanced head and neck squamous cell carcinoma (HNSCC) treatment. METHODS AND RESULTS: PPa was chemically conjugated to the HA polymeric nanoparticle via an adipic acid dihydrazide (ADH) linker. The conjugates were injected subcutaneously in a region near the tumor. Near-infrared (NIR) imaging was used to monitor distribution, and diode laser was used to activate PPa. The singlet oxygen generation efficiency of PPa was not affected by conjugation to HA nanoparticles at a PPa loading degree of 1.89 w.t.%. HA-ADH-PPa inhibited human HNSCC MDA-1986 cell growth only when photo-irradiation was applied. After HA-ADH-PPa treatment and radiation, NU/NU mice bearing human HNSCC MDA-1986 tumors showed reduced tumor growth and significantly enhanced survival time compared with an untreated group (p < 0.05). CONCLUSIONS: These results demonstrate that HA-ADH-PPa could be useful for in vivo locoregional photodynamic therapy of HNSCC.

Vitamin K2 Awareness in Sun-Protected Patients Supplementing With Vitamin D.

Dermatologists often recommend vitamin D for sun-protected patients. Most patients are not aware of the key role vitamin K2 plays in vitamin D metabolism and do not receive sufficient dietary vitamin K2. A survey of 50 sun-protecting patients shows 4/50 understood the role of vitamin K2 and 1/50 was supplementing vitamin K2. Therefore, counseling on vitamin K2 supplementation may be of benefit to sun-protected dermatology patients. J Drugs Dermatol. 2021;20(2):228-229. doi:10.36849/JDD.5829.