RESUMEN
A C20-diterpenoid alkaloid with an unprecedented carbon skeleton, acoapetaludine A, together with ten undescribed aconitine-type C19-diterpenoid alkaloids, acoapetaludines B-K, were isolated from the whole plants of Aconitum apetalum (Huth) B. Fedtsch. (Ranunculaceae). The structures were elucidated based on a comprehensive spectroscopic data analysis. The absolute configuration of acoapetaludine A was determined by quantum ECD calculation. Acoapetaludines D and E exhibited weak anti-Helicobacter pylori activity at a minimum inhibitory concentration (MIC) of 100 and 50⯵g/mL, respectively.
Asunto(s)
Aconitum/química , Alcaloides/química , Alcaloides/farmacología , Antibacterianos/química , Antibacterianos/farmacología , Diterpenos/química , Helicobacter pylori/efectos de los fármacos , Pruebas de Sensibilidad Microbiana , Modelos Moleculares , Conformación MolecularRESUMEN
Seven new anthranilamide derivatives, acoapetalines A-G (1-7), including one new naturally occurring compound (7), together with six known ones (8-13) were isolated from the whole plants of Aconitum apetalum. Their structures were established on the basis of extensive spectroscopic analyses (IR, UV, HRESIMS, 1D and 2D NMR). All compounds were evaluated for their anti-tobacco mosaic virus (anti-TMV) activities. The results showed that compound 10 exhibited significant anti-TMV activity with an inhibition rate of 67.57% (100⯵g/mL), which was higher than that of ningnamycin (52.89%).
