The REM-sleep-related characteristics of narcolepsy: a nation-wide multicenter study in Turkey, the REMCON study.

INTRODUCTION: Narcolepsy type 1 (NT1) is caused by hypocretin deficiency, the pathophysiology of narcolepsy type 2 (NT2) has not been delineated. Except for the hypocretin deficiency and cataplexy, all clinical and laboratory features used in the diagnosis of NT2 are identical to those used for NT1. The aim of this study was to assess the rapid eye movement (REM) sleep-related characteristics in the patients with narcolepsy; the characteristics of REM sleep in polysomnography (PSG) and multiple sleep latency test (MSLT) recordings, the quantification of REM sleep without atonia (RSWA) and atonia index, and the analysis of rapid eye movements (REMs) during REM sleep. MATERIALS AND METHODS: This study was planned by the Sleep Medicine Study Group of the Turkish Neurology Society, and conducted in 11 centers in eight cities in Turkey. The analysis of RSWA was analyzed by reviewing all REM sleep periods on nocturnal PSG and MSLT recordings per standard criteria. The total duration of the increased muscle tone during REM sleep in the chin and bilateral leg electromyography (EMG) recordings was calculated as RSWA index. The REMs index was also investigated the relation to the RSWA. RESULTS: A total of 274 patients were involved; 147 patients (53.6%) were males and 127 patients (46.4%) were females; the mean age was 29.1 ± 12.0 years. The diagnosis of NT1 was made in 166 patients (60.6%), and 108 patients (39.4%) were diagnosed as having NT2. The mean Epworth sleepiness scale score was significantly higher in patients with NT1 than the patients with NT2 (P = 0.001). The diagnosis of REM sleep behavior disorder (RBD) was made in 19.3% of the patients with NT1 versus in 2.8% of the patients with NT2 (P < 0.001). The percentage of SOREMP in PSG recordings was significantly higher in patients with NT1 (37.1%) than those with NT2 (18.9%, P = 0.001). MSLT showed that the mean sleep latency was shorter in patients with NT1 compared to those with NT2 (P < 0.001). The total duration of REMs on electrooculography recordings was also significantly higher in patients with RSWA in comparison with the patients without RSWA (P = 0.002). Total duration of REMs was significantly and positively correlated with the duration of RSWA on chin-EMG and leg-EMG recordings (P = 0.001). ROC analyses showed an RSWA index of ≥2% for the RSWA on chin-EMG with a sensitivity of 86.7% and a specificity of 71.3% (P < 0.001). The REMs index ≥20% was associated with the presence of RSWA with a sensitivity of 70.0% and a specificity of 57.1% (P = 0.008). CONCLUSIONS: In this nation-wide study, we identified for the first time that the increase in REMs density during REM sleep may be a major correlate of the RSWA. Significant positive correlations were demonstrated between the total duration of REMs on electrooculography recordings and the mean durations of RSWA in both chin and leg EMG recordings. A REMs index of >20% was demonstrated to have a moderate sensitivity and specificity in the diagnosis of RSWA. As observed in chin RSWA index, REMs index also showed a significantly high association with RBD, in comparison to RSWA per standard criteria.

The Effects of Mobile Electronic Devices Use on the Sleep States of University Students.

Objective: In this study, the purpose was to evaluate the effect of mobile electronic devices (MEDs) use on the sleep states of university students. Methods: The study was conducted in a cross-sectional fashion between April 21, 2019 and May 31, 2019 with the participation of the students registered in a public university at medical faculties and faculty of health sciences. Television viewing, MED and desktop computer use form, Morningness-Eveningness Questionnaire, Pittsburgh Sleep Quality Index (PSQI), Epworth Sleepiness Scale (ESS), and Sleepiness Severity Index (SSI) were used as data collection tools. The data of 752 students (56.5% girls, mean age: 20.57 [SD = 1.54] years) were analyzed. Results: In this study, overall MED use times and PSQI, ESS, and SSI total scores were higher in students who had an evening-oriented chronotype. There was a negative relationship between overall and evening MED use times and the chronotype scores of the students. As a result of the regression analyses applied to the PSQI, ESS, and SSI dependent variables, a positive and significant relationship was detected with smartphone use times (P < 0.05, P = 0.05, and P < 0.001, respectively). In addition, there was a positive relationship between PSQI and ESS variables and iPod touch use times (P < 0.001 and P < 0.05, respectively). Conclusion: Overall MED use times were determined to be higher in students who had Type E chronotype. It was also determined that their sleep quality was poorer and their insomnia severity was higher, and there was more sleepiness in the students with chronotype E. Comprehensive interventions must be planned by professional healthcare staff for students on the topics of sleep hygiene and conscious media use.

Turkish reliability and validity study of the medical outcomes study (MOS) sleep scale in patients with obstructive sleep apnea

Background/aim: The purpose of the present study was to evaluate the Turkish reliability and validity of the medical outcomes study (MOS) sleep scale in patients who have obstructive sleep apnea. Materials and methods: The data of the study were collected from 120 adult patients with obstructive sleep apnea and from 90 healthy individuals between March 04 and May 31, 2019. Results: The Cronbach's α internal consistency reliability coefficient of the MOS sleep scale was found as 0.82. The test-retest reliability was acceptable (r = 0.76-0.94). Six factors were identified by the factor analysis. These were the same as those in the original MOS-Sleep. The correlations between the MOS-Sleep and other instruments administered in this study provided evidence for structural validity. A significant relation was determined between MOS sleep scale and obstructive sleep apnea syndrome (OSAS) severity and the healthy group ( P < 0.05). In addition, the Cronbach α internal consistency reliability coefficient of the healthy group in MOS sleep scale was found as 0.78. The items of the six factors that were obtained with the confirmatory factor analysis for the MOS sleep scale of the healthy group were found to be the same as in the original MOS-Sleep. Conclusion: Turkish MOS sleep scale is a measurement tool that consists of 12 items and 6 subdimensions with adequate validity and reliability indicators.

Relationship between Apnea-Hypopnea Index and Oxygen Desaturation in REM-Sleep Period and Morning Headache in Patients with Obstructive Sleep Apnea Syndrome.

INTRODUCTION: In patients with morning headache, REM sleep period decreases though little is known about its physiopathology. We evaluate the polysomnographic records of obstructive sleep apnea syndrome (OSAS) patients with the hypothesis that oxygen desaturations may be a better determinant in patients with morning headache, especially those in REM sleep periods. METHODS: Patient group (group 1) with a total of 361 patients with OSAS and the controls (group 2) with 107 healthy individuals were evaluated. The presence of morning headache was compared between the groups, and sleep parameters were correlated with morning headache. RESULTS: In group 1, patients with OSAS and morning headache, apnea-hypopnea index in the REM sleep period (26.7/hour, min-max: 0-108.4/hour) was higher than those in patients without morning headache (17.8/hour, min-max: 0-107.8/hour). The minimum oxygen saturation in REM sleep period and total sleep time (TST) was lower in patients with morning headache (REM sleep period: 82%, min-max: 50-94% ; TST: 79%, min-max: 50-97%) in compared to patients without morning headache (REM sleep period: 84%, min-max: 50-93% ; TST: 81%, min-max: 50-90%). CONCLUSION: Here we demonstrated that higher apnea-hypopnea index and lower oxygen saturation in REM sleep period were associated with morning headache in patients with obstructive sleep apnea syndrome.

What are the factors that contribute to aggression in patients with co-occurring antisocial personality disorder and substance abuse?

Abstract Background A significant number of individuals with high levels of aggression have substance use disorder problems. Objective This study aimed to evaluate the effect of substance use disorder on aggression in young men with Antisocial personality disorder (ASPD). Methods This cross-sectional study included 328 patients and were diagnosed with ASPD with a comorbidity of substance use disorder, along with 111 healthy young male subjects. Results The total aggression scores of the patients with a diagnosis of ASPD were significantly higher than those of the healthy group (p < 0.001). Mean scores of aggression subscale, except for indirect aggression, were higher in patients diagnosed with ASPD (p < 0.05). There was a positive correlation between aggression scores and total API scores in patients diagnosed with ASPD (p < 0.001). Aggression scores were higher when subjects were using volatile substances compared to other substances (p < 0.05). Aggression scores increased with duration of substance use disorder (p < 0.001). Discussion Substance use disorder should be treated first to mitigate aggression in individuals with ASPD. Patients with severe addiction to volatile substances should be given treatment priority. Further studies are necessary to determine the cause of aggression in individuals who abuse substances.

The effect of computer game playing habits of university students on their sleep states.

OBJECTIVE: The aim of this study is to evaluate the effect of computer game playing habits of university students on their sleep states. DESIGN AND METHODS: The study was conducted cross-sectionally with the online survey method. FINDING: In this study, it was determined that the students who played games for an average of ≥2 hours per day had later bedtime and later wake-up time, poorer sleep quality, and higher daytime sleepiness. It was found that as the level of game addiction increased, sleep quality decreased, the severity of daytime sleepiness increased, and the wake-up time shifted to a later time. PRACTICE IMPLICATIONS: Nurses should develop effective intervention strategies involving technology management and sleep hygiene studies to reduce game-playing time of students.

The influence of media on the sleep quality in adolescents.

Akçay D, Akçay BD. The influence of media on the sleep quality in adolescents. Turk J Pediatr 2018; 60: 255-263. This study was conducted to evaluate the influence of media devices on sleep quality in adolescents. Applying a descriptive design, the study was carried out with 9th, 10th and 11th grade students (N=392, 52.0% female, average age 16.04±0.86) who were attending Konya High School between the dates of January 18 and 22, 2016. Changes were seen to occur in the wake-up times of those who had either a television or a computer in their bedrooms (p < 0.005, p < 0.05, respectively). Overall, it was determined that the students who participated in the study had poor sleep quality (66.6%). A positive correlation was detected between the amount of time the adolescents spent watching TV, using the internet, and playing games on their mobile phone, and the wake-up times (r=0.154, p < 0.005; r=0.152, p < 0.005; r=0.258, p < 0.001; r=0.232, p < 0.001, respectively). A negative correlation was detected between playing computer/console games and listening to music and sleep duration in the adolescents (respectively, r=-0.149, p < 0.005; r=-0.107, p < 0.05). The results showed that as the adolescents spent more time with their media products (except TV watching), their sleep quality deteriorated. In adolescents, the duration and quality of sleep were found to be affected by certain aspects of media use. It is therefore recommended that families regulate the intended purpose and content of their children's media use and limit the time spent with media. Moreover, media products should be removed from their bedrooms. More training and intervention studies on sleep patterns and media literacy should be conducted with this study group.

Effects of subjective sleep quality on the quality of life in patients with chronic anorectal disorder.

OBJECTIVE: The aim of the present study was to evaluate the subjective sleep quality in patients with anorectal disorder, to determine the factors associated with subjective sleep quality, and to explore the relationship between subjective sleep quality and quality of life. MATERIAL AND METHODS: This descriptive study was conducted between April 8, 2015 and April 12, 2016. The research population consisted of 284 patients who attended the general surgery outpatient clinics of Konya Military Hospital and were subsequently diagnosed with one of the four most common anorectal disorders (hemorrhoidal disease, anal fissure, anorectal abscess/fistula, and sacrococcygeal pilonidal disease). Data were collected from 114 patients who volunteered to participate in the study. After establishment of the diagnosis based on proctological anamnesis and physical examination, the Pittsburgh Sleep Quality Index, Short-Form Health Survey, Beck Anxiety Inventory, and Beck Depression Inventory were administered to the patients, along with a questionnaire on sociodemographic data, via a face-to-face interview technique. RESULTS: Ninety-six (84.2%) patients had poor sleep quality, whereas 18 (15.8%) patients had good sleep quality. Among the patients with poor sleep quality, 16 were diagnosed with anorectal abscess and fistula (100.0%), 40 with hemorrhoidal disease (90.9%), 16 with sacrococcygeal pilonidal disease (80.0%), and 24 with anal fissure (70.6%). Overall, all patients with poor sleep quality (n=96) had low scores in all subcomponents of the quality of life scale. CONCLUSION: The sleep quality in patients with chronic anorectal disorder is significantly impaired, thus negatively affecting quality of life. Therefore, improvement in quality of life by improving sleep quality should be one of the main objectives in treating chronic anorectal disorders.