1.
Am J Med Genet A
; 140(9): 1016-20, 2006 May 01.
Artículo
en Inglés
| MEDLINE
| ID: mdl-16619202
Asunto(s)
Aberraciones Cromosómicas , Cromosomas Humanos Par 5/genética , Síndrome del Maullido del Gato/genética , Deleción Cromosómica , Síndrome del Maullido del Gato/patología , Cara/anomalías , Resultado Fatal , Duplicación de Gen , Humanos , Hibridación Fluorescente in Situ , Lactante , Cariotipificación , Masculino , Modelos Genéticos
2.
Pediatr Hematol Oncol
; 19(1): 51-8, 2002.
Artículo
en Inglés
| MEDLINE
| ID: mdl-11787867
RESUMEN
A major cause of morbidity and mortality in thalassemic patients is infections, assumed to be the result of immunological changes. In this study immune functions of peripheral blood lymphocytes have been studied in 38 beta-thalassemia major, 12 beta-thalassemia trait, and 17 healthy children. Results show decrease in CD4+/CD8+ ratios in the beta-thalassemia major group and no difference according to absolute T-lymphocyte numbers and activated T-cell numbers. These results do not correlate with the tendency to infection. No significant difference was found in humoral immunity. The study of other factors in thalassemia is needed to detect those who are more susceptible to infections.