RESUMEN
Results of observation were analyzed in 68 patients with Ewing's sarcoma. Reagents made by DAKO (France) such as CD-31, endothelial cell, clone JC 70A, isotype: Lg GI, kappa 02/1 ml were used in the study. It was estimated, that CD31 expression activity in endothelial elements was inversely proportional and reliably correlated with malignant process by the Ewing's sarcoma. Indices of lymphoid infiltration in pathological focus were inversely proportional to the expression of CD-31 positive cells. Statistically reliable inversely proportional relationship was revealed between CD-31 expression of endothelial cells and spontaneous tissue necrotization in the Ewing's sarcoma. Reliable direct correlation was ascertained between tumor angiogenesis and amount of CD-31.
Asunto(s)
Neoplasias Óseas/irrigación sanguínea , Sarcoma de Ewing/irrigación sanguínea , Progresión de la Enfermedad , Células Endoteliales/metabolismo , Células Endoteliales/patología , Humanos , Inmunohistoquímica , Neovascularización Patológica/metabolismo , Neovascularización Patológica/patología , Molécula-1 de Adhesión Celular Endotelial de Plaqueta/biosíntesisRESUMEN
Clinico-morphologic and immunohystochemical characteristics of the angiogenesis were analyzed in 24 patients with malignant osseous lymphoma. Maximal density of CD-31 positive cells was registered. Immunopositivity was shown for cytoplasm and cell wall. Authors consider the elevated rate of CD-31 positive cells in tumor stroma to be a negative prognostic factor after radical surgery for malignant osseous lymphoma.