Antegrade Versus Retrograde Approach to Interlocking Nail Fixation of Femoral Diaphyseal Fractures: Is there Difference in Time to Union?

BACKGROUND: Antegrade reamed interlocked intramedullary nailing is the treatment of choice forfemoral diaphyseal fractures. More recently, retrograde intramedullary nailing of the femur has been seen as a viable alternative to the antegrade nail. METHODS: This was a prospective comparative study. Consecutive patients were placed alternately into a study group (retrograde nailing) and a control group (antegrade nailing) in a ratio of 2:1 i.e two retrograde nailing for every antegrade nailing. Forty one fractures had interlocking intramedullary fixation via the retrograde approach (study group), while the control group consisted of twenty fractures that had fixation via the antegrade approach. All were followed up for a minimum period of nine months (range of nine to twenty-four months). RESULTS: The mean duration of surgery in the retrograde group was 157.07minutes and 137.40 minutes in the antegrade group (p=0.093). The mean duration to fracture union was 16.98±4.71 weeks in the retrograde group and 15.80±5.43 weeks in the antegrade group (p = 0.388). There was no incidence of non-union in the two groups. CONCLUSION: Retrograde approach compares favourably with antegrade approach for intramedullary interlocking nail fixation of diaphyseal femoral fracture in adults with respect to time of fracture healing.

Comparison of effect of retrograde and antegrade approaches to interlocking nail fixation of femoral diaphyseal fractures on ipsilateral hip and knee joint motion.

PURPOSE: The objective of this study was to evaluate the early impact of antegrade and retrograde interlocking nail fixation of femoral diaphyseal fractures on the ipsilateral hip and knee joint range of motion. METHODS: A prospective evaluation was performed of 62 consecutive limbs with femoral diaphyseal fractures that had interlocking nail fixation through the antegrade or retrograde approaches. All participants had post-operative physiotherapy. Follow-up was for 9 months. RESULTS: The mean maximum hip flexion angle at 9 months was 137.50 in the antegrade group and 133.80 in the retrograde group (p = 0.150). Trendelenburg test was negative in both groups and there was no knee extension lag at 9 months. While the mean maximum knee flexion angle at 9 months was 119.90 in the retrograde group and 134.50 in the antegrade group (p = 0.023). All patients had achieved radiologic and clinical fracture union by twenty four weeks post-operatively. CONCLUSION: There was no significant effect of antegrade or retrograde approach on the range of motion of the hip joint. However, knee motion improved more quickly in the group that had antegrade nailing.

Challenges in the management of floating knee injuries in a resource constrained setting.

Floating knee injuries pose major challenges in management. There is little information on the patterns of these injuries and the challenges of managing them in our setting. Patients with floating knee injuries who were seen and treated over a 5-year period at our center were retrospectively reviewed. The patterns of the injuries, associated injuries, methods of management and factors that influenced the outcome were analyzed. Twenty-five patients, consisting of 19 males and 6 females with a mean age of 33.4 ± 16.04 years, satisfied the study criteria. All were caused by road traffic injuries, motor cycle crashes accounting for 19 (76%). Twenty-two (88%) injuries were Blake and McBryde type 1, while 3 (12%) were of type 2A. Thirty-two percent of the patients had surgical fixation of both fractures, while 40% of the patients had both fractures managed non-operatively. Non-operative management strongly correlated with development of malunion. The results of management of floating injuries in our setting are not satisfactory. Orthopedic and trauma care should be made accessible to those requiring it.

CHARACTERISATION OF BACTERIAL ISOLATES FROM PATIENTS WOUNDS AND ENVIRONMENTAL FACTORS PREDICTIVE OF POST-SURGICAL INFECTIONS AT THE ORTHOPAEDIC WARD IN ILE-IFE, NIGERIA.

OBJECTIVE: To determine the pattern of orthopaedic wound infection and the influence of environmental factors on the distribution of the etiologic bacterial agents. DESIGN: A prospective observational study. SETTING: Department of Orthopaedic Surgery and Traumatology, Obafemi Awolowo University Teaching Hospitals Complex, Ile-Ife, Nigeria. SUBJECTS: Sixty patients with orthopaedic wound infections and orthopaedic ward environment. RESULTS: Thirty- nine males (mean age 33.31+2SD) and 21 females (mean age 27.47 + 2SD) with orthopaedic wounds. Three hundred and ten bacteria (190 from patients and 120 from ward environment) were isolated. The pattern of bacterial isolates from patients' wounds was different from that of the airborne bacterial isolates irrespective of the length of stay on the ward. There was a significant difference in the distribution and resistance pattern of bacterial isolates from the patient's wounds and ward environment. CONCLUSION: There is a high incidence of antibiotic resistance of bacterial isolates from samples cultured from patients compared with isolates from ward environment at this centre. The extensive use of pre-operative prophylactic and post-surgical antibiotics in various combinations at this centre needs to be re-examined to reduce the preponderance of antibiotic resistance.

Use of wound drains following open reduction and internal fixation of femoral shaft fractures.

OBJECTIVE: To determine if routine use of closed suction wound drainage is justified following open reduction and internal fixation of femoral-shaft fractures. METHOD: Patients undergoing reduction and internal fixation of 75 femoral shaft fractures were prospectively randomised into two groups: one receiving closed-suction drainage (CSD) and one no wound drainage (NWD). The state of the wound dressing at 24 and 48 hours post-surgery, blood transfusion requirements, status of the wound (presence of hyperaemia, surgical site infection, undue wound tenderness, presence of induration at the wound edge and wound healing) at days 7, 14, 28 and 90 postoperatively, and duration of wound healing, were assessed. RESULTS: A total of 65 patients, with 75 femoral shaft fractures, completed the study: 37 fractures in CSD group and 38 in the NWD group. No significant difference was observed between the two groups in terms of the state of wound dressing at 24 hours (p=0.192) or 48 hours (p=0.365). There was no statistically significant difference in the incidence of wound infection (X2=3.339, df=2, p=0.188) or duration of wound healing (X2=3.168, df=1, p=0.075) between the two groups. However, more patients in the CSD group had blood transfusions than in the NWD group (21.6% vs 15.8%), although this was also not statistically significant (p=0.181). CONCLUSION: No benefit was observed in the routine use of wound drains following open reduction and internal DECLARATION OF INTEREST: There were no external sources of funding for this study. The authors have no additional conflicts of interest to declare.

Outcome of non-operative management of femoral shaft fractures in children.

BACKGROUND: Femoral shaft fractures are common injuries in childhood. There is paucity of information on their presentation and outcome of the available treatment methods in the African population. This study evaluated the outcome of non-operative methods of treatment of femoral shaft fractures in our centre. PATIENTS AND METHODS: A retrospective review of the database of children aged 14 years and below with femoral shaft fractures treated non-operatively over a 10-year period. RESULTS: A total of 134 patients with 138 fractures met the study criteria. This consisted of 71 boys (mean age = 6.1 years ± SD) and 63 girls (mean age = 6.5 years ± SD). Pedestrian vehicular accident was the most common cause of femoral shaft fractures in the study population. The midshaft was the most common site of fractures. There were associated injuries to other parts of the body (especially head injury) in 34.3% of the patients. The commonest mode of treatment was skin traction only (87.7%). The mean time to fracture union was 4.9 weeks ± SD (range = 3-15 weeks). The mean length of hospitalisation was 6.7 weeks ± SD (range = 5 days-11 weeks). There was a fairly strong positive correlation between the length of hospitalisation and the presence of associated injuries, especially head injury, upper limb fractures and bilaterality of the fractures. The mean total cost of treatment was #7685 (Naira) or $51.2 (range = $14.2-$190). At the last follow up, 97.8% of the fractures united without significant angulation or shortening. CONCLUSION: The outcome of non-operative treatment of femoral shaft fractures in our setting is comparable to the results of other workers. Methods of treatment that shorten the length of hospitalisation without unduly increasing cost should be encouraged.

Outcome of non-operative management of femoral shaft fractures in children

Background: Femoral shaft fractures are common injuries in childhood. There is paucity of information on their presentation and outcome of the available treatment methods in the African population. This study evaluated the outcome of non-operative methods of treatment of femoral shaft fractures in our centre. Patients and Methods: A retrospective review of the database of children aged 14 years and below with femoral shaft fractures treated non-operatively over a 10-year period. Results: A total of 134 patients with 138 fractures met the study criteria. This consisted of 71 boys (mean age = 6.1 years ± SD) and 63 girls (mean age = 6.5 years ± SD). Pedestrian vehicular accident was the most common cause of femoral shaft fractures in the study population. The midshaft was the most common site of fractures. There were associated injuries to other parts of the body (especially head injury) in 34.3% of the patients. The commonest mode of treatment was skin traction only (87.7%). The mean time to fracture union was 4.9 weeks ± SD (range = 3-15 weeks). The mean length of hospitalisation was 6.7 weeks ± SD (range = 5 days-11 weeks). There was a fairly strong positive correlation between the length of hospitalisation and the presence of associated injuries, especially head injury, upper limb fractures and bilaterality of the fractures. The mean total cost of treatment was #7685 (Naira) or $51.2 (range = $14.2-$190). At the last follow up, 97.8% of the fractures united without significant angulation or shortening. Conclusion: The outcome of non-operative treatment of femoral shaft fractures in our setting is comparable to the results of other workers. Methods of treatment that shorten the length of hospitalisation without unduly increasing cost should be encouraged

Mortality among orthopaedic and traumatology admissions: a ten year review.

OBJECTIVE: Mortality in orthopaedic patients is not a common event. This study sets out to review the incidence and causes of mortality in orthopaedic and trauma admissions in a tertiary centre in a developing country. METHODS: Medical records of patients admitted to the Orthopaedic wards of the Obafemi Awolowo University Teaching Hospital, Ile-Ife over a ten year period (January 1999-December 2008) were retrospectively reviewed. The death certificates and postmortem examination findings were used in conjunction with the medical records to arrive at the possible cause of death in the deceased patients. Frequency analysis was done using SPSS version 13. RESULTS: Over this period, 2418 patients were admitted for orthopaedic and trauma with 84 deaths giving an overrall crude mortality rate of 3.47% (1.27% for paediatrics and 4.39% for the adults). Fourty nine patients (58.4%) died from trauma (fracture) related diagnoses followed by tumour (21, 25%) and infection (14,16.7%). Males were more affected 73.8% and the average age at death was 45.7years. Co-morbid conditions were found in 393% of the deceased patients. CONCLUSION: Trauma related deaths were the leading cause of mortality in our ward admissions and male patients at the prime of their lives were more often involved. Accident prevention and provision of facilities for appropriate management of trauma victims will help reduce substantially these untimely deaths in our world. The high incidence of co-morbid conditions emphasizes the role of multidisciplinary care in orthopaedic and trauma patients.

A simple technique for the placement of Schanz screws into bone using minimal radiologic control.

The insertion of Schanz screws into the bone during external-fixation procedures in trauma and elective orthopaedic surgery is usually done under röentgenologic control. In order to minimize irradiation exposure for the patients, as well as surgeons, we describe a simple method of Schanz screw placement. The röentgenologic control of the position of the half-pins is only necessary at the beginning and the end of the procedure. This technique is simple, shortens the operating time and reduces the amount of radiation exposure to both the patient and surgeon. It is a valuable technique in many resource-poor environments who do not have the facilities for an image intensifier fluoroscopy or C-arm as well as in austere situations such as during military operations.

Direct integration of government funding and family support for musculoskeletal tumor care in a resource-constrained country.

BACKGROUND: Malignant musculoskeletal tumor (MMST) outcome reflects the level of supportive care provided. In Nigeria, the supportive care available to patients with MMST is limited by a lack of funding. Patients often present late, and receive only orthodox care as psychosocial care is not available. We evaluated the effect of direct incorporation of government funding and family support on MMST patient acceptance and completion of treatment. METHODS: A 3-year prospective multicenter intention-to-treat study was undertaken in a tertiary care setting. The first step was a nonselective randomization of MMST patients into 2 groups, Wesley Guilds Hospital Firm A (WGHFA) and Wesley Guilds Hospital Firm B (WGHFB) using the computer software Excel. The control group was WGHFA, which consisted of patients who self-financed their oncology care. The WGHFB patients' governments (local or state) provided funds according to medical reports and the patients had relatives who offered psychosocial support. The second step entailed treatment (surgery, chemotherapy and radiotherapy) and follow-up. Outcome measures were the interval between presentation at hospital and surgical intervention, acceptability of limb amputation, completeness of treatment courses, duration of hospital stay and mortality. The reproducibility of the methodology was reappraised at the Federal Medical Center. Kruskal-Wallis analysis was used, and an alpha error of <0.05 at a CI of 95% was taken to be significant. RESULTS: A total of 112 cases of MMST were managed during the study period. Seventy-one (63.4%; 37 WGHFA; 34 WGHFB) met the inclusion criteria. Age, sex, tribe, religion, comorbid factors and mean weekly income were not significant factors influencing improved MMST care among the WGHFB patients. 32 WGHFB versus 7 WGHFA patients accepted the treatment plan. The mean duration of hospital stay before surgery (p < 0.001), discharge against medical advice (p < 0.000), limb salvage (21 vs. 2, p < 0.001), limb amputation (3 vs. 12, p < 0.05, 95% CI 8.3-37.9), completeness of treatment (33 vs. 7, p < 0.05), mean duration of hospital stay, in days (23 vs. 39, p < 0.05) and mortality at 1-year follow-up (13 vs. 28, p < 0.02) were significant. CONCLUSION: The cost of cancer care is a challenge for patients with MMST in a resource-constrained country such as Nigeria. Direct integration of the government and family into MMST care will serve as a link between the cancer patient and the source of funds. It raises the possibility of an effective psychosocial approach to improve patient outcome through enhanced treatment acceptability and completion, and so reduce morbidity and short-term mortality.

Therapeutic decision in chronic osteomyelitis: sinus track culture versus intraoperative bone culture.

BACKGROUND: The ideal specimen for identification of the etiologic agents in chronic osteomyelitis for best antibiotic decision remains controversial. OBJECTIVE: To assess the concordance of sinus track culture (STC) with that of intraoperative bone culture (IBC) to guide antibiotic therapy in chronic osteomyelitis. METHODS: A prospective comparative study of chronic osteomyelitis patients seen in our centre from January 2004 to December 2006. Specimens from the depths of sinus track and intraoperative bone biopsy were obtained from each patient and subjected to microbiologic examination and their concordance determined. RESULTS: In STCs Staphylococcus aureus has the highest sensitivity (60.5%), specificity (45.0%) and positive predictive value (72.2%). The overall sensitivity (50.9%), specificity (20%) and predictive value (47.5%) of sinus track specimens were very low. Antibiotic decision based on IBC showed 106 patients (82.8%) had resolution of chronic osteomyelitis at mean of 2 years follow-up. CONCLUSION: IBC appears to predict more reliably the complete etiologic organisms than STCs in chronic osteomyelitis.

Risk factors for osteonecrosis of the femoral head in patients with sickle cell disease.

The mechanisms involved in the pathogenesis of osteonecrosis of the femoral head in sickle cell disease are not fully known. The aim of this study was to identify risk factors for osteonecrosis of the femoral head among sickle cell disease patients. Clinical (frequency of painful crises and hospitalisation) and laboratory parameters (euglobulin clot lysis time, haematocrit, platelet count, and leucocyte count) of 25 consecutive patients with avascular necrosis of the femoral head from sickle cell disease were compared with those of 26 age- and sex-matched sickle cell disease patients without avascular necrosis. The group with avascular necrosis of the femoral head (mean age 23.7+/-4.9 years) had a significantly higher rate of painful crises (p = 0.03) and hospitalisations per year (p = 0.002) than the group without avascular necrosis (mean age 21.6+/-5.2 years). The group with avascular necrosis also had a significantly higher euglobulin clot lysis time than the group without avascular necrosis (p = 0.001). In conclusion, it appears that not all patients with sickle cell disease have impaired fibrinolytic activity. The aetiology of avascular necrosis in sickle cell disease is multifactorial.

Factors influencing the outcome of elective paediatric orthopaedic operations in Ile-Ife, Nigeria.

There is a paucity of published data on the types of paediatric orthopaedic conditions that require surgery and factors influencing their outcome in most parts of Sub-Saharan Africa. This is a necessary audit to improve paediatric orthopaedic practice. We carried out an audit of all elective orthopaedic operations performed in children at Awolowo University Teaching Hospitals Complex in Ile-Ife, Nigeria from January 2000 through December 2005. The aim was to document the clinical outcomes and the factors that influence them. This is with a view to instituting necessary measures to improve paediatric orthopaedic practice in the area. A total of 146 children who had elective operations on 210 limbs were included in the study. Their mean age was 75.6 +/- 66.8 months (range 0.3-396 months). The commonest indications for surgery were angular knee deformities (from Blount's disease and rickets) and club foot. The mean hospital stay before surgery was 12 +/- 8.8 days (range 1-38 days). The mean duration of operation was 78.4 +/- 36 min. (range 30-195 min). The total length of hospitalization was 34.97 +/- 19.91 days in males and 41.97 +/- 25.15 days in females. Wound infection was the commonest postoperative complication (8.2%). The patient's age (P = 0.002), indication for surgery (P = 0.008), length of preoperative hospital stay (P = 0.048), length of operation (P < 0.001) and intraoperative blood loss above 200ml (P < 0.001) were found to be statistically significant factors adversely affecting the surgical wound outcome. We conclude that most of the factors that predicted poor outcome in this study were patient and environment-related and are preventable. There is need to upgrade facilities in health institutions in Nigeria.

Microbiology of amputation wound infection in a Nigerian setting.

OBJECTIVE: To identify the microbial pathogens responsible for amputation wound infections, their distribution and antibiotic-sensitivity patterns. METHOD: Consecutive patients who had limb amputations from April 2002 to March 2006 in an Nigerian hospital were recruited into this prospective observational study. The patients' demographic features, indications for amputation, microbiology of stump wound infections and the effects on length of hospital stay were reported. RESULTS: Fifty-seven patients (mean age 34.6 +/- 19.2 years) had amputations in 58 limbs. Trauma leading to limb gangrene following treatment by traditional bone setters was the most common indication for amputation (64%). Approximately 76% of the amputations were in the lower limbs. Wound infection occurred in 48% of the stumps, of which 71% had been amputated because of a trauma injury. Pseudomonas aeruginosa was the most commonly isolated pathogen (40%).There was a very low correlation between the aetiologic bacterial agents and the age of patient, source of referral, indication for amputation and level of amputation. Amputation wound infections significantly prolonged the patients' length of hospital stay (p=0.002). CONCLUSION: Amputation wound infection constitutes a serious morbidity in our practice. Most of the causes are preventable.

Factors Infuencing the Outcome of Elective Paediatric Orthopaedic Operations in Ile-Ife; Nigeria

There is a paucity of published data on the types of paediatric orthopaedic conditions that require surgery and factors infl uencing their outcome in most parts of Sub-Saharan Africa. This is a necessary audit to improve paediatric orthopaedic practice. We carried out an audit of all elective orthopaedic operations performed in children at Awolowo University Teaching Hospitals Complex in Ile-Ife, Nigeria from January 2000 through December 2005. The aim was to document the clinical outcomes and the factors that infl uence them. This is with a view to instituting necessary measures to improve paediatric orthopaedic practice in the area. A total of 146 children who had elective operations on 210 limbs were included in the study. Their mean age was 75.6±66.8 months (range 0.3-396 months). The commonest indications for surgery were angular knee deformities (from Blount/'s disease and rickets) and club foot. The mean hospital stay before surgery was 12±8.8 days (range 1-38days). The mean duration of operation was 78.4±36min. (range 30-195 min). The total length of hospitalization was 34.97±19.91 days in males and 41.97±25.15 days in females. Wound infection was the commonest postoperative complication (8.2%). The patient/'s age (P=0.002), indication for surgery (P=0.008), length of preoperative hospital stay (P=0.048), length of operation (P<0.001) and intraoperative blood loss above 200ml (P<0.001) were found to be statistically signifi cant factors adversely affecting the surgical wound outcome. We conclude that most of the factors that predicted poor outcome in this study were patient and environment-related and are preventable. There is need to upgrade facilities in health institutions in Nigeria

Avascular necrosis of the femoral head in sickle cell disease in Nigeria: a retrospective study.

BACKGROUND: Avascular necrosis (AVN) especially of the femoral head, has long been recognised as a manifestation of sickle cell disease (SCD). Despite this knowledge the actual prevalence of this complication among sickle cell patients in Nigeria is not known. OBJECTIVE: To determine the prevalence and patterns of presentation of avascular necrosis of the femoral head in sickle cell disease. PATIENTS AND METHODS: A retrospective study carried out at the Orthopaedic and Haematology clinics of Obafemi Awolowo University Teaching Hospitals Complex, Ile-Ife, Nigeria. Four hundred and sixteen patients with sickle cell disease seen over a 15-year period. RESULTS: Of the 416 patients with sickle cell disease 340 (81.7%) had haemoglobin SS genotype while 76(18.3%) had SC genotype. Sixty-six (15.9%) patients 35 males (53%) and 31 females (47%) had clinical and radiologic features of avascular necrosis (AVN) of the femoral head. Fifty-three of them (80.3%) had Hb SS while 13 had Hb SC. The peak age incidence in both Hb SS and Hb SC was 21-30 years. Forty patients (60.6%) presented with stage IV disease (Ficat and Arlet Staging) while 21.2% had stage III and 18.2% had stage II. No patient was diagnosed in stage 1 or 0. CONCLUSION: The prevalence of AVN of femoral head in Hb SC and HbSS is similar i.e. the difference is not statistically significant (P=0.48). Most of our patients present late with advanced diseases. Considering the paucity of facilities available for total hip replacement in Nigeria and the young age group affected we recommend regular screening of patients with sickle cell disorder for AVN and regular community educational programmes for early diagnosis.

Esmarch tourniquet in orthopaedic surgery.

A bloodless field is important in many orthopaedic operations necessitating the use of a pneumatic tourniquet or Esmarch bandage. The outcome of the use of an Esmarch bandage for exsanguination and as a tourniquet in 112 consecutive patients who had elective orthopaedic operations on 131 limbs was evaluated. The setting was at Obafemi Awolowo University Teaching Hospitals Complex, Ile-Ife, Nigeria, from March 2003 to February 2005. The mean age of the patients was 25.7 + standard deviation years (range 1-70 years). The duration of tourniquet application ranged from 20 min to 2 h 35 min. Four limbs (3.1%) developed acute compartment syndrome; four (3.1%) had tourniquet paralysis with ulnar nerve involvement in three limbs. All limbs regained full neurological function following physiotherapy. There was wound infection in two limbs (1.5%). In spite of its drawbacks, the Esmarch bandage is still useful for exsanguination and as a tourniquet in orthopaedic surgery where there is no pneumatic tourniquet.

Microbial isolates in early swabs of open musculoskeletal injuries.

BACKGROUND: Infections of open musculoskeletal injuries, especially open fractures, continue to pose a challenge to the Orthopaedic and Trauma surgeons. There is a dearth of information on the early bacterial contaminants of these open wounds and their antibiotic sensitivity patterns in our environment. OBJECTIVE: To determine the bacteriology of open wounds of the musculoskeletal system at initial presentation in hospital and their antibiotic susceptibility profile in Ile-Ife, Nigeria. MATERIALS AND METHODS: A prospective study of 86 consecutive patients over an eight-month period (March to October 2002). Eighty-six patients with 96 open wounds of the musculoskeletal system admitted to the Accident and Emergency unit of the Obafemi Awolowo University Teaching Hospitals Complex, Ile-Ife. Bacteria were isolated from swabs taken from the depth of the wounds and their antibiotic susceptibility determined. RESULTS: A total of 126 bacterial isolates were recovered from 96 wounds in 86 patients (61 males and 25 females) with mean age of 31.4 years +/- SD. About 73.3% of the wounds were from road traffic accidents and 72.3% of the wounds were severe open fractures (Grades IIIA to C). Staphylococcus aureus constituted 22.2% while coagulase negative Staphylococci (CONS) accounted for 21.4% with Staphylococcus. epidermidis leading the group with 13.5%. Gram negative rods constituted 40.5% of the isolates with Pseudomonas aeruginosa accounting for 11.1%. Antibiotic sensitivity profile revealed that many of the isolates were multiply resistant to the antimicrobials employed but were sensitive to Ofloxacin. CONCLUSION: This study has shown that open wounds of the musculoskeletal system are usually contaminated at presentation with pathogenic organisms. The antibiotic sensitivity pattern of the isolates shows that the quinolones, represented by Ofloxacin, is the most effective antibiotic.

African histoplasmosis - masquerading as a malignant bone tumour.

A 23-year-old immunocompetent woman presented with a two-month history of fungating left shoulder and left elbow swellings associated with fever, weight loss and anaemia. X-rays showed lytic destruction of the lateral third of the left clavicle and distal half of the left humerus. Histology of biopsy specimen confirmed African histoplasmosis. The lesion resolved following treatment with ketoconazole.

Septic arthritis in children.

BACKGROUND: Septic arthritis is an important osteoarticular infection in children. There is insufficient data on its pattern of presentation and sequelae in our environment. OBJECTIVE: To identify the aetiologic factors, patterns of presentation and sequelae of septic arthritis in Nigerian children. METHODS: A retrospective analysis of the clinical, roentgenographic and laboratory records of children with septic arthritis admitted over a 14-year period to Obafemi Awolowo University Teaching Hospitals Complex, Ile-Ife, Nigeria was undertaken. RESULTS: Ninety three patients with septic arthritis involving 104 joints with a mean age of 4.5 years +/- SD (range 2 months to 15 years) were studied. The most commonly involved joint was the hip (48.4%) though the shoulder was the most commonly affected joint in infancy (36%). Trauma (a history of fall and intramuscular injection) was associated in 28% of the cases. Staphylococcus aureus was the predominant aetiologic bacterial agent (50%) even in patients with sickle cell disease. Anaemia was a common complication (64.5%). The overall result of treatment was unsatisfactory as only 37.7% had complete resolution while most had varying degrees of joint destruction resulting in limb length discrepancy and ankylosis.