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1.
Heart Surg Forum ; 23(1): E034-E038, 2020 02 10.
Artículo en Inglés | MEDLINE | ID: mdl-32118540

RESUMEN

BACKGROUND: The study is presenting our long-term clinical results after freestyle stentless aortic root bioprosthesis replacement in patients with severe aortic insufficiency with ascending aortic aneurysm. METHODS: Seventy-seven patients with ascending aortic aneurysms and aortic valve insufficiency underwent a total root replacement procedure using a stentless "Freestyle" valve (Medtronic Inc., Minneapolis, Minnesota). There were 50 (64.9%) men and 27 (35.1%) women. Mean age was 68.7 ± 11.1 years. The surgical procedure used a complete root replacement. Concomitant procedures included coronary artery bypass grafting in 15 (19.5%) patients. RESULTS: The mean cardiopulmonary bypass time was 130.3 ± 26.4 minutes and total aortic cross clamp time was 99.5 ± 23.6 minutes. Hospital mortality was 2.6%. The median follow-up time was 11.2 years. The 5- and 10-years freedom from aortic valve reoperation were 97.4 ± 1.2% and 93.4 ± 4.9%, respectively. During 10 years follow up, there were 14 late deaths; 4 deaths were cardiac, and 10 deaths were noncardiac. Valve-related deaths were attributable to thromboembolism in 1 patient, endocarditis in 2 patients, and congestive heart failure in 1 patient. CONCLUSION: The freestyle stentless aortic root bioprosthesis offered good clinical outcomes, in terms of survival and structural valve deterioration. The Freestyle valve is a viable option for use in patients undergoing bioprosthetic aortic valve replacement and expected desire for long-term durability.


Asunto(s)
Aneurisma de la Aorta/cirugía , Insuficiencia de la Válvula Aórtica/cirugía , Válvula Aórtica/cirugía , Bioprótesis , Prótesis Valvulares Cardíacas , Anciano , Puente de Arteria Coronaria , Femenino , Estudios de Seguimiento , Implantación de Prótesis de Válvulas Cardíacas/efectos adversos , Implantación de Prótesis de Válvulas Cardíacas/instrumentación , Implantación de Prótesis de Válvulas Cardíacas/métodos , Humanos , Masculino , Persona de Mediana Edad , Tempo Operativo , Complicaciones Posoperatorias , Diseño de Prótesis , Reoperación , Resultado del Tratamiento
2.
Cardiovasc J Afr ; 30(3): e3-e6, 2019.
Artículo en Inglés | MEDLINE | ID: mdl-30729976

RESUMEN

Sporadic ca rdiac myxomas rarely recur, however recurrence rates are higher in patients with a familial aggregation or Carney complex. Carney complex is characterised by multiple mucocutaneous lesions and accounts for up to two-thirds of familial cardiac myxomas. A second recurrence is very rare, even in the case of Carney complex. We report on two cases of recurrent cardiac myxoma, a mother and daughter, who concurrently presented with a second recurrence of atrial myxomas. The time interval between the first and second recurrence following surgery was four years in both. The possibility of repeat recurrence of cardiac myxomas demonstrates the importance of regular echocardiography to detect recurrence and to prevent the potential complications associated with cardiac myxomas. Family screening should be recommended for familial myxomas.


Asunto(s)
Complejo de Carney/genética , Neoplasias Cardíacas/genética , Madres , Mixoma/genética , Recurrencia Local de Neoplasia/genética , Complejo de Carney/diagnóstico por imagen , Complejo de Carney/patología , Complejo de Carney/cirugía , Femenino , Predisposición Genética a la Enfermedad , Atrios Cardíacos/diagnóstico por imagen , Atrios Cardíacos/patología , Atrios Cardíacos/cirugía , Neoplasias Cardíacas/diagnóstico por imagen , Neoplasias Cardíacas/patología , Neoplasias Cardíacas/cirugía , Herencia , Humanos , Persona de Mediana Edad , Mixoma/diagnóstico por imagen , Mixoma/patología , Mixoma/cirugía , Recurrencia Local de Neoplasia/diagnóstico por imagen , Recurrencia Local de Neoplasia/patología , Linaje , Fenotipo , Factores de Riesgo , Factores de Tiempo , Adulto Joven
3.
Turk Gogus Kalp Damar Cerrahisi Derg ; 27(2): 152-158, 2019 Apr.
Artículo en Inglés | MEDLINE | ID: mdl-32082846

RESUMEN

BACKGROUND: In this study, we aimed to evaluate the long-term outcomes of monopolar or bipolar radiofrequency ablation concomitant to mitral valve surgery in patients with atrial fibrillation. METHODS: We retrospectively evaluated a total of 167 patients (67 males, 100 females; mean age 56.8±6.9 years; range, 48 to 65 years) with atrial fibrillation who underwent monopolar or bipolar radiofrequency ablation concomitant to mitral valve surgery between September 2001 and January 2015. The patients were divided into two groups according to the procedure applied as those undergoing monopolar ablation (group 1, n=68) and those undergoing bipolar ablation (group 2, n=99). All patients were followed by electrocardiogram and 24-h Holter monitoring. Echocardiography was performed before discharge, at three and 12 months postoperatively, and annually thereafter. Left atrial volume index, left atrial diameter, and left ventricular ejection fraction were recorded. RESULTS: There was no significant correlation between the procedure applied and hypertension, hyperlipidemia, diabetes mellitus, chronic obstructive pulmonary disease, history of the cerebrovascular events (p>0.05). The mean preoperative left atrial diameter decreased from 5.3±0.5 cm to 4.9±0.5 cm postoperatively in all patients (p=0.0001). The mean preoperative left atrial volume index decreased from 53.8±0.4 mL/m2 t o 43.7±6.2 m L/m2 i n t he postoperative period (p=0.0001). During follow-up, 61.8% (n=42) of the patients in group 1 and 62.6% (n=62) of the patients in group 2 remained in sinus rhythm. One patient (1.5%) in group 1 and two patients (2.0%) in group 2 developed early postoperative cerebrovascular accident. CONCLUSION: Monopolar and bipolar ablation methods are safe and effective methods to ensure long-term sinus rhythm. Both procedures do not increase the morbidity risk with very low thromboembolic complication rates.

4.
Turk Gogus Kalp Damar Cerrahisi Derg ; 27(4): 469-470, 2019 Oct.
Artículo en Inglés | MEDLINE | ID: mdl-32082911
5.
Turk Gogus Kalp Damar Cerrahisi Derg ; 28(2): 407-409, 2019 Jun.
Artículo en Inglés | MEDLINE | ID: mdl-32551178

RESUMEN

In this article, we present our experience with an easy and practical technique for measuring the length of neo-chordae during minimally invasive mitral valve repair. This technique is based on tying the knots at the level of the plane of the ring using a prolene suture passing through the transverse diameter of the ring as a guideline.

6.
Heart Surg Forum ; 19(4): E165-8, 2016 Aug 19.
Artículo en Inglés | MEDLINE | ID: mdl-27585193

RESUMEN

OBJECTIVE: Minimally invasive bypass grafting is a promising surgical treatment in proximal LAD stenosis procedures. The main goal of this study was to make comparisons between robotically assisted minimally invasive coronary bypass surgery and conventional surgery in isolated proximal LAD lesions in terms of pain and quality of life improvement. METHODS: The study contains patients with proximal LAD lesions who were treated with robotically assisted minimally invasive coronary artery bypass surgery and conventional bypass surgery between June 2005 and November 2012. Fifty patients treated with coronary bypass with cardiopulmonary bypass and complete sternotomy were categorized as Group 1. Fifty patients who applied for robotically assisted minimally invasive bypass surgery were categorized as Group 2. The evaluations of pain and quality of life were done according to the Verbal Rating Scale (VRS) and SF-36 health survey questionnaire, respectively. RESULTS: The conventional bypass group and robotic group had 4.8 ± 1.9 years and 4.3 ± 1.6 years mean follow-up time, respectively. The robotic bypass group had a significantly shorter ICU stay and hospital stay than the conventional bypass group (P < .05). The pain score was higher in the robotic bypass group on the 1st postoperative day (P < .05), but the score on the 4th postoperative day was higher in the conventional bypass group (P < .05). In terms of domains of the SF-36 questionnaire, patient scores were significantly higher in patients who were operated with robotically assisted minimally invasive direct coronary artery bypass (MIDCAB) procedure than in patients who were operated with conventional bypass technique. CONCLUSION: Patients operated with robotically assisted MIDCAB procedure had results with lesser pain, shorter ICU stay, and shorter hospital stay than the other group in isolated proximal LAD stenosis. The same group also had better quality of life results according to the SF-36 questionnaire results.


Asunto(s)
Puente de Arteria Coronaria/métodos , Enfermedad de la Arteria Coronaria/cirugía , Procedimientos Quirúrgicos Mínimamente Invasivos/métodos , Dimensión del Dolor , Dolor Postoperatorio/diagnóstico , Calidad de Vida , Procedimientos Quirúrgicos Robotizados/métodos , Adulto , Anciano , Anciano de 80 o más Años , Femenino , Estudios de Seguimiento , Humanos , Masculino , Persona de Mediana Edad , Estudios Retrospectivos , Resultado del Tratamiento
7.
Heart Surg Forum ; 18(2): E042-6, 2015 Apr 28.
Artículo en Inglés | MEDLINE | ID: mdl-25924029

RESUMEN

BACKGROUND: Minimally invasive bypass grafting surgery has entered the clincal routine in several centers around the world, with an increasing popularity in the last decade. In our study, we aimed to make a comparison between minimally invasive coronary artery bypass grafting surgery and conventional bypass grafting surgery in isolated proximal left anterior descending artery (LAD) lesions. METHODS: Between January 2004 and December 2011, patients with proximal LAD lesions, who were treated with robotically assisted minimally invasive coronary artery bypass surgery and conventional bypass surgery, were included in the study. In Group 1, coronary bypass with cardiopulmonary bypass and complete sternotomy were applied to 35 patients and in Group 2, robotically assisted minimally invasive bypass surgery was applied to 35 patients. The demographic, preoperative, perioperative, and postoperative data were collected retrospectively. RESULTS: The mean follow-up time of the conventional bypass group was 5.7 ± 1.7 years, whereas this ratio was 7.3 ± 1.3 in the robotic group. There was no postoperative transient ischemic attack (TIA), wound infection, mortality, or need for intra-aortic balloon pump (IABP) in any of the patients. In the conventional bypass group, blood transfusion and ventilation time were significantly higher (P < .05) than in the robotic group. The intensive care unit (ICU) stay and hospital stay were remarkably shorter in the robotic group (P < .01). The postoperative pneumonia rate was significantly higher (20%) in the conventional bypass group (P < .01). Postoperative day 1 pain score was higher in the robotic group (P < .05), however, postoperative day 3 pain score in the conventional bypass group was higher (P < .05). Graft patency rate was 88.6% in the conventional bypass group whereas this ratio was 91.4% in the robotic bypass group, which was not clinically significant (P > .05). CONCLUSIONS: In isolated proximal LAD stenosis, robotic assisted minimally invasive coronary artery bypass grafting surgery requires less blood products, is associated with shorter ICU and hospital stay, and lesser pain in the early postoperative period in contrast to conventional surgery. The result of our studies, which showed similarities to the past studies, lead us to recognize the importance of minimally invasive interventions and the need to perform them more frequently in the future.


Asunto(s)
Puente de Arteria Coronaria/estadística & datos numéricos , Enfermedad de la Arteria Coronaria/epidemiología , Enfermedad de la Arteria Coronaria/cirugía , Procedimientos Quirúrgicos Mínimamente Invasivos/estadística & datos numéricos , Complicaciones Posoperatorias/epidemiología , Procedimientos Quirúrgicos Robotizados/estadística & datos numéricos , Puente de Arteria Coronaria/métodos , Femenino , Humanos , Masculino , Persona de Mediana Edad , Procedimientos Quirúrgicos Mínimamente Invasivos/métodos , Tempo Operativo , Prevalencia , Estudios Retrospectivos , Factores de Riesgo , Procedimientos Quirúrgicos Robotizados/métodos , Resultado del Tratamiento , Turquía
8.
Cardiovasc Pathol ; 22(3): 183-8, 2013.
Artículo en Inglés | MEDLINE | ID: mdl-22955009

RESUMEN

OBJECTIVE: Cardiac visceral fat is accepted to be a new marker for cardiometabolic risk due to its association with increased cardiovascular risk factors. This study aimed to compare the expression of 11 beta hydroxysteroid dehydrogenases (11ß-HSD)-1, glucocorticoid receptor (GCR), and CD68 in mediastinal and subcutaneous adipose tissues (MAT, and SAT, respectively) and to assess their possible relationships with the development of coronary artery disease (CAD). METHODS AND RESULTS: Expression of 11ß-HSD-1, GCR, and CD68 mRNA levels were measured by quantitative real-time polymerase chain reaction in MAT and SAT tissues of 37 patients undergoing coronary artery bypass grafting due to CAD (CAD group) and 19 non-CAD patients (controls) undergoing heart valve surgery. 11ß-HSD-1 in MAT and SAT and GCR expression in MAT and SAT were found to be significantly increased in CAD group when compared with controls (P<.05, respectively). In CAD group, 11ß-HSD-1 mRNA levels were found to be significantly higher in MAT compared to SAT (P<.05). CD68 mRNA levels were significantly higher in MAT of CAD group compared to controls (P<.05). Immunohistochemical analyses demonstrated the presence of CD68+ cells and increased 11ß-HSD-1 expression in MAT of CAD group compared to SAT. CONCLUSION: The present study demonstrate that the mediastinal fat exhibits a pathogenic mRNA profile of 11ß-HSD-1, GCR, and CD68. The identification of 11ß-HSD-1 expression within the mediastinal fat, along with increased GCR expressions and the presence of CD68+ cells highlight that MAT potentially contributes to the pathogenesis of CAD.


Asunto(s)
11-beta-Hidroxiesteroide Deshidrogenasa de Tipo 1/biosíntesis , Antígenos CD/biosíntesis , Antígenos de Diferenciación Mielomonocítica/biosíntesis , Enfermedad de la Arteria Coronaria/metabolismo , Grasa Intraabdominal/metabolismo , Receptores de Glucocorticoides/biosíntesis , Enfermedad de la Arteria Coronaria/patología , Femenino , Humanos , Inmunohistoquímica , Masculino , Mediastino/patología , Persona de Mediana Edad , ARN Mensajero/análisis , Reacción en Cadena en Tiempo Real de la Polimerasa
9.
Cardiovasc Diabetol ; 11: 115, 2012 Sep 25.
Artículo en Inglés | MEDLINE | ID: mdl-23009206

RESUMEN

BACKGROUND: Visceral fat deposition and its associated atherogenic complications are mediated by glucocorticoids. Cardiac visceral fat comprises mediastinal adipose tissue (MAT) and epicardial adipose tissue (EAT), and MAT is a potential biomarker of risk for obese patients. AIM: Our objective was to evaluate the role of EAT and MAT 11beta-hydroxysteroid dehydrogenase type 1 (11ß-HSD-1) and glucocorticoid receptor (GCR) expression in comparison with subcutaneous adipose tissue (SAT) in the development of coronary atherosclerosis in obese patients with coronary artery disease (CAD), and to assess their correlations with CD68 and fatty acids from these tissues. METHODS AND RESULTS: Expression of 11ß-HSD-1 and GCR was measured by qRT-PCR in EAT, MAT and SAT of thirty-one obese patients undergoing coronary artery bypass grafting due to CAD (obese CAD group) and sixteen obese patients without CAD undergoing heart valve surgery (controls). 11ß-HSD-1 and GCR expression in MAT were found to be significantly increased in the obese CAD group compared with controls (p < 0.05). In the obese CAD group, 11ß-HSD-1 and GCR mRNA levels were strongly correlated in MAT. Stearidonic acid was significantly increased in EAT and MAT of the obese CAD group and arachidonic acid was significantly expressed in MAT of the obese male CAD group (p < 0.05). CONCLUSIONS: We report for the first time the increased expression of 11ß-HSD-1 and GCR in MAT compared with EAT and SAT, and also describe the interrelated effects of stearidonic acid, HOMA-IR, plasma cortisol and GCR mRNA levels, explaining 40.2% of the variance in 11ß-HSD-1 mRNA levels in MAT of obese CAD patients. These findings support the hypothesis that MAT contributes locally to the development of coronary atherosclerosis via glucocorticoid action.


Asunto(s)
11-beta-Hidroxiesteroide Deshidrogenasa de Tipo 1/análisis , Enfermedad de la Arteria Coronaria/enzimología , Hidrocortisona/análisis , Grasa Intraabdominal/enzimología , Isquemia Miocárdica/enzimología , Obesidad/enzimología , Receptores de Glucocorticoides/análisis , 11-beta-Hidroxiesteroide Deshidrogenasa de Tipo 1/genética , Anciano , Antígenos CD/análisis , Antígenos de Diferenciación Mielomonocítica/análisis , Ácido Araquidónico/análisis , Estudios de Casos y Controles , Puente de Arteria Coronaria , Enfermedad de la Arteria Coronaria/genética , Enfermedad de la Arteria Coronaria/cirugía , Ácidos Grasos Omega-3/análisis , Femenino , Humanos , Modelos Lineales , Masculino , Mediastino , Persona de Mediana Edad , Análisis Multivariante , Isquemia Miocárdica/genética , ARN Mensajero/análisis , Receptores de Glucocorticoides/genética , Reacción en Cadena de la Polimerasa de Transcriptasa Inversa , Grasa Subcutánea/enzimología
10.
Heart Surg Forum ; 14(4): E214-20, 2011 Aug.
Artículo en Inglés | MEDLINE | ID: mdl-21859638

RESUMEN

BACKGROUND: We evaluated the results of different types of cardiovascular surgery in patients with chronic renal failure (CRF) (serum creatinine ≥2 mg/dL) who were not dialysis-dependent. METHODS: Eighty-two patients who presented with non-dialysis-dependent CRF were retrospectively evaluated. Patients in Group 1 (n = 12) underwent valvular surgery, those in Group 2 (n = 58) underwent coronary artery bypass grafting (CABG), and those in Group 3 (n = 12) underwent combined CABG and valvular surgery. RESULTS: The demographics were similar among the groups. Cardiopulmonary bypass and aortic cross-clamping times were shorter (P < .01), the use of blood and blood products was less, and the mechanical ventilation time and hospital stay were shorter in Group 2 in comparison to the other groups (P < .01). There were 4 (6.9%) early mortalities in Group 2. Late mortalities occurred in 4 (33.3%), 16 (27.6%), and 6 (50%) patients from Groups 1, 2, and 3, respectively. Cox regression analysis revealed that age, the presence of a preoperative cerebrovascular accident, the presence of a left main coronary lesion, preoperative blood urea nitrogen level, and the use of blood and blood products were independent risk factors for early mortality. High Euroscore, cerebrovascular accident, the use of platelet suspension, longer ventilation support times, and combined CABG and valvular surgery were independent risk factors for late mortality. CONCLUSIONS: Morbidity and survival seemed to be more dependent on preoperative patient characteristics than the type of surgery in this group of patients. Combined CABG and valvular surgery was a risk factor for late mortality.


Asunto(s)
Procedimientos Quirúrgicos Cardíacos , Creatinina/metabolismo , Tasa de Filtración Glomerular/fisiología , Cardiopatías/cirugía , Fallo Renal Crónico/complicaciones , Anciano , Nitrógeno de la Urea Sanguínea , Progresión de la Enfermedad , Femenino , Estudios de Seguimiento , Cardiopatías/complicaciones , Cardiopatías/epidemiología , Humanos , Incidencia , Fallo Renal Crónico/epidemiología , Fallo Renal Crónico/terapia , Masculino , Persona de Mediana Edad , Pronóstico , Diálisis Renal , Estudios Retrospectivos , Factores de Riesgo , Tasa de Supervivencia/tendencias , Turquía/epidemiología
11.
Turk Kardiyol Dern Ars ; 39(4): 320-4, 2011 Jun.
Artículo en Inglés | MEDLINE | ID: mdl-21646835

RESUMEN

Budd-Chiari syndrome (BCS) is a rare disorder characterized by hepatic venous obstruction. A 41-year-old male patient presented with right upper quadrant pain, abdominal distension, and dyspnea. He had a history of BCS that was associated with polycythemia vera. Abdominal computed tomography showed hepatomegaly and a hypodense filling defect suggestive of thrombus formation in the hepatic, splenic, and portal veins, and suprahepatic part of the inferior vena cava. Transthoracic echocardiography performed to assess the extension of this pathological process and its relation with intracardiac structures showed a mass lesion in the right atrium, about 4 x 3 cm in diameter. The lesion manifested as an intracardiac thrombus extending from the inferior vena cava. The patient underwent surgical treatment to remove the atrial mass. At surgery, the lesion turned out to be an atrial tumor, which was diagnosed as atrial myxoma in histopathologic examination. The symptoms of the patient resolved after surgery.


Asunto(s)
Síndrome de Budd-Chiari , Neoplasias Cardíacas/diagnóstico , Mixoma/diagnóstico , Vena Porta , Vena Esplénica , Trombosis de la Vena/diagnóstico , Adulto , Diagnóstico Diferencial , Atrios Cardíacos , Neoplasias Cardíacas/complicaciones , Neoplasias Cardíacas/diagnóstico por imagen , Neoplasias Cardíacas/cirugía , Humanos , Masculino , Mixoma/complicaciones , Mixoma/diagnóstico por imagen , Mixoma/cirugía , Ultrasonografía , Trombosis de la Vena/complicaciones , Trombosis de la Vena/diagnóstico por imagen , Trombosis de la Vena/cirugía
12.
Ann Vasc Surg ; 25(5): 669-74, 2011 Jul.
Artículo en Inglés | MEDLINE | ID: mdl-21439768

RESUMEN

BACKGROUND: The greater saphenous vein remains the most common conduit used in coronary artery bypass grafting procedures. Surgical trauma during vein harvesting can cause endothelial and smooth muscle injury that has important implications for vein graft longevity. This study was designed to investigate the effect of clipping and ligation of the side-branches during saphenous vein graft harvesting on histologic structures of the saphenous vein. MATERIAL AND METHODS: A total of 50 coronary artery bypass grafting patients (37 men and 13 women, mean age of 59 ± 6 years) were investigated in two groups according to side-branch closing method. In each patient, two side-branches were studied; one of them was ligated using 3/0 silk suture, and the other one was clipped next to the saphenous vein. Each venous sample was studied using hematoxylin and eosin, Masson's trichrome, and elastic tissue fibers-Verhoeff's Van Gieson staining. Histopathologic examination using light microscope was performed to assess intimal, elastic tissue, muscular layer, and adventitial changes. The pathologic alterations were graded on the basis of a scoring system (normal [0], minimal changes [+], mild changes [++], or severe changes [+++]) to assess the degree of damage inflicted by these two different types of branch closing methods. RESULTS: Histologic examination of venous tissue samples with ligated side-branches demonstrated vascular injury in most sections, including denudation and loss of the integrity of the endothelial layer of the vein. An evident disorganization of the subintimal collagen and elastic fibers was also reported. By contrast, histopathologic structure of most sections obtained from the specimens with clipped side-branches remained intact. Intimal, elastic tissue, muscular layer, and adventitial changes were significantly different between the two methods (p = 0.001). CONCLUSIONS: Clipping, rather than ligation, of the side-branches of the saphenous vein conduit during its harvesting for coronary bypass grafting is associated with decreased vein damage. These findings suggest that clipping of the side-branches can be used without major detrimental effects on vascular integrity.


Asunto(s)
Puente de Arteria Coronaria , Vena Safena/trasplante , Recolección de Tejidos y Órganos/métodos , Procedimientos Quirúrgicos Vasculares , Lesiones del Sistema Vascular/prevención & control , Anciano , Femenino , Humanos , Ligadura , Masculino , Persona de Mediana Edad , Vena Safena/lesiones , Recolección de Tejidos y Órganos/efectos adversos , Turquía , Procedimientos Quirúrgicos Vasculares/efectos adversos , Lesiones del Sistema Vascular/etiología , Lesiones del Sistema Vascular/patología
13.
Anadolu Kardiyol Derg ; 11(1): 39-47, 2011 Feb.
Artículo en Turco | MEDLINE | ID: mdl-21220245

RESUMEN

OBJECTIVE: Chronic atrial fibrillation (AF) is a frequent arrhythmia in patients undergoing open-heart surgery. In this study, we compared the results of irrigated monopolar and bipolar radiofrequency (RF) ablation in the surgical treatment of AF. METHODS: Sixty-three patients with chronic AF, who underwent open cardiac surgery and concomitant irrigated RF ablation between October 2004 and January 2006, were retrospectively studied in two groups. Group 1 included 31 patients (22 female, 9 male), who underwent monopolar RF ablation, and Group 2 included 32 patients (18 female, 14 male), who underwent bipolar RF ablation. All patients received amiodarone during the first 6 months after surgery. Rhythm status of patients after RF ablation was followed-up postoperatively in the intensive care unit, on the day of discharge, and at their follow-ups with electrocardiography. In patients with a documented sinus rhythm (SR) at follow-up, the presence of atrial transport function was assessed with transthoracic echocardiography. Statistical analyses were performed by using t-test for independent samples, Chi-square test and McNemar's test. Complication-free survival during follow-up was evaluated using Kaplan-Meier analysis. RESULTS: There was no hospital mortality in both groups. One patient from Group 1 had non-cardiac mortality (colon carcinoma). While in monopolar ablation group SR was documented in 83.3% of patients at a mean follow-up period of 11.5 ± 4.0 months (between 4-18 months), 68.8% of patients from bipolar ablation group was in SR at a mean follow-up period of 9.3 ± 3.0 months (between 4-15 months). In patients with documented SR during follow-up visits, atrial transport function was 76.6% in cases undergoing monopolar ablation, whereas it was 72.7% in cases undergoing bipolar ablation (p=0.797). Pacemaker implantation was performed in one (3.4%) patient from Group 1 after hospital discharge and in one (3.1%) patient from Group 2 during hospital stay. CONCLUSION: Irrigated monopolar and bipolar RF ablation are both safe and effective in terms of restoring SR and atrial transport function in patients with chronic AF, who underwent open cardiac surgery.


Asunto(s)
Fibrilación Atrial/cirugía , Ablación por Catéter/métodos , Adulto , Anciano , Anciano de 80 o más Años , Amiodarona/uso terapéutico , Antiarrítmicos/uso terapéutico , Fibrilación Atrial/tratamiento farmacológico , Fibrilación Atrial/mortalidad , Enfermedad Crónica , Ecocardiografía , Electrocardiografía , Femenino , Estudios de Seguimiento , Humanos , Masculino , Persona de Mediana Edad , Estudios Retrospectivos , Análisis de Supervivencia
14.
J Card Surg ; 24(6): 661-3, 2009.
Artículo en Inglés | MEDLINE | ID: mdl-19732223

RESUMEN

The optimal technique for myocardial protection and cardioplegia delivery during totally endoscopic robotic surgery is still under evolution. Cardioplegia delivery with endovascular clamping of the aorta is a common method used for this purpose but has several disadvantages and may lead to serious complications. Here we describe an alternative cardioplegia delivery method during totally endoscopic atrial septal defect closure and mitral valve repair. The method using a transthoracic aortic clamp and an antegrade cardioplegia cannula without any thoracotomy seems to be a safe and reproducible technique, which may enhance myocardial protection and prevent some of the complications of the endoclamp technique during robotically assisted cardiac surgery.


Asunto(s)
Soluciones Cardiopléjicas/administración & dosificación , Puente Cardiopulmonar/métodos , Defectos del Tabique Interatrial/cirugía , Válvula Mitral/cirugía , Robótica/métodos , Cirugía Asistida por Computador/métodos , Toracoscopía/métodos , Aorta Torácica , Puente Cardiopulmonar/instrumentación , Diseño de Equipo , Humanos , Robótica/instrumentación , Cirugía Asistida por Computador/instrumentación , Instrumentos Quirúrgicos , Toracotomía/instrumentación , Toracotomía/métodos
15.
J Card Surg ; 24(6): 710-5, 2009.
Artículo en Inglés | MEDLINE | ID: mdl-19754676

RESUMEN

BACKGROUND: Degenerative ascending aortic aneurysms frequently present with aortic valve pathology. If only the noncoronary sinus of Valsalva is dilated, replacement of the noncoronary sinus by tailoring the supracoronary graft with or without aortic valve replacement (AVR) can be a simple operation strategy. We sought to describe our experiences in this kind of operation, and compare them with a relatively homogeneous group of patients who underwent the classical Bentall operation. METHODS: Between January 1997 and June 2007, 99 patients who had dilated ascending aortas with root dilatation and aortic valve pathology underwent operation. Patients were divided into three groups according to the surgical procedure. Classical Bentall operation was applied in 54 patients with dilated sinuses (Group 1). The other patients with dilated noncoronary sinus underwent either ascending aortic replacement with noncoronary sinus replacement (NSR, n = 27) (Group 2), or separate AVR and ascending aortic replacement with NSR (AVR + NSR, n = 18) (Group 3). RESULTS: There were significant reduction of aortic root in Group 2 (Z =-4.560, p < 0.001), and Group 3 (Z =-3.758, p < 0.001). Degree of aortic regurgitation was decreased from 1.56 +/- 0.5 to 0.67 +/- 0.5 postoperatively in Group 2 (Z =-3.874, p < 0.001). Hospital mortality was six (6.1%) (three in Group 1; three in Group 2). Late mortality rate was 6.1% (three in Group 1, three in Group 2). The type of operation was not found to be an independent predictor of overall mortality. No patients in the NSR and AVR-NSR groups had aortic root aneurysm, and there were no reoperations or verified deaths caused by aortic root aneurysm in these patients. CONCLUSIONS: Noncoronary cusp replacement for aortic root remodeling in patients with ascending aortic aneurysm is a technically simple and durable operation. Short- and mid-term results of this method were favorable compared to the Bentall procedure.


Asunto(s)
Aneurisma de la Aorta Torácica/cirugía , Disección Aórtica/cirugía , Insuficiencia de la Válvula Aórtica/cirugía , Estenosis de la Válvula Aórtica/cirugía , Válvula Aórtica/cirugía , Implantación de Prótesis Vascular/métodos , Implantación de Prótesis de Válvulas Cardíacas/métodos , Diseño de Prótesis , Seno Aórtico/cirugía , Anciano , Disección Aórtica/diagnóstico , Disección Aórtica/mortalidad , Aneurisma de la Aorta Torácica/diagnóstico , Aneurisma de la Aorta Torácica/mortalidad , Insuficiencia de la Válvula Aórtica/diagnóstico , Insuficiencia de la Válvula Aórtica/mortalidad , Estenosis de la Válvula Aórtica/diagnóstico , Estenosis de la Válvula Aórtica/mortalidad , Aortografía , Ecocardiografía , Ecocardiografía Transesofágica , Femenino , Estudios de Seguimiento , Humanos , Procesamiento de Imagen Asistido por Computador , Imagenología Tridimensional , Masculino , Persona de Mediana Edad , Complicaciones Posoperatorias/etiología , Complicaciones Posoperatorias/mortalidad , Tasa de Supervivencia , Tomografía Computarizada Espiral
16.
Int J Med Robot ; 5(2): 170-7, 2009 Jun.
Artículo en Inglés | MEDLINE | ID: mdl-19253902

RESUMEN

BACKGROUND: The aim of this study was to assess the feasibility of robotically enhanced myocardial revascularization and to present the clinical outcome of 196 patients. METHODS: All internal thoracic arteries were harvested with the aid of a robotic surgical system. While off-pump revascularization techniques were mostly used, peripheral cardiopulmonary bypass was needed in some cases with multivessel disease. RESULTS: A single (n = 118) or multivessel (n = 74) coronary revascularization was performed. Four patients had to be converted to median sternotomy. There was no operative mortality. Follow-up was complete in 88% (n = 169) patients. The rate of freedom from ischaemic symptoms was 98.2% at mean 22 +/- 3 months. Graft patency was 96.4% (81/84). CONCLUSIONS: By increasing surgical capabilities, robotically enhanced CABG in single or multivessel coronary disease was safe, effective and reasonable. It can be an alternative approach to percutaneous methods and conventional surgical techniques, or even used in acute coronary events.


Asunto(s)
Puente de Arteria Coronaria/métodos , Robótica/métodos , Cirugía Asistida por Computador/métodos , Adulto , Anciano , Puente de Arteria Coronaria/efectos adversos , Puente de Arteria Coronaria/instrumentación , Puente de Arteria Coronaria Off-Pump/efectos adversos , Puente de Arteria Coronaria Off-Pump/instrumentación , Puente de Arteria Coronaria Off-Pump/métodos , Enfermedad de la Arteria Coronaria/cirugía , Femenino , Humanos , Masculino , Arterias Mamarias/cirugía , Persona de Mediana Edad , Complicaciones Posoperatorias/etiología , Robótica/instrumentación , Cirugía Asistida por Computador/instrumentación , Resultado del Tratamiento
17.
Ann Thorac Surg ; 87(1): 299-301, 2009 Jan.
Artículo en Inglés | MEDLINE | ID: mdl-19101319

RESUMEN

Percutaneous vertebroplasty is a useful and safe therapeutic intervention to stabilize vertebral fractures. Rarely, cement leakage into the paravertebral venous system may result in embolization of its particles into the right cardiac chambers and pulmonary artery. We experienced a case of a 64-year-old woman who was diagnosed through echocardiography as having cardiac tamponade. Previously, the patient was treated for pulmonary cement embolization after percutaneous vertebroplasty. Prompt diagnosis and urgent surgery, in which a few linear cement particles of 1-cm to 2-cm long were discovered within the pericardial space, which resulted in a favorable outcome.


Asunto(s)
Taponamiento Cardíaco/etiología , Embolia Pulmonar/etiología , Fracturas de la Columna Vertebral/terapia , Vértebras Torácicas/lesiones , Vertebroplastia/efectos adversos , Taponamiento Cardíaco/diagnóstico por imagen , Taponamiento Cardíaco/cirugía , Dolor en el Pecho/diagnóstico , Dolor en el Pecho/etiología , Tratamiento de Urgencia/métodos , Femenino , Estudios de Seguimiento , Humanos , Persona de Mediana Edad , Pericardiocentesis/métodos , Embolia Pulmonar/diagnóstico por imagen , Embolia Pulmonar/tratamiento farmacológico , Radiografía , Enfermedades Raras , Medición de Riesgo , Fracturas de la Columna Vertebral/diagnóstico por imagen , Toracotomía/métodos , Terapia Trombolítica/métodos , Resultado del Tratamiento , Vertebroplastia/métodos
19.
Cardiovasc Pathol ; 17(6): 392-8, 2008.
Artículo en Inglés | MEDLINE | ID: mdl-18417367

RESUMEN

BACKGROUND: Metabolic syndrome is a cluster of different clinical manifestations that are risk factors for atherothrombotic cardiovascular disorders. Fatty-acid-binding protein 4 (FABP4/aP2), which is highly expressed in adipocytes, specifically exerts intracellular lipid trafficking. A high level of fatty-acid-binding protein 4 expression present in obese subjects has also been found in mice and humans, especially in macrophages at atherosclerotic lesions. An in vivo study demonstrated that the inhibitor of aP2 would be a new therapeutic agent for treating metabolic diseases in mice. We have investigated the mRNA expression of fatty-acid-binding protein 4 in human epicardial adipose and ascending aorta tissues of metabolic syndrome and nonmetabolic syndrome patients. METHODS: Paired epicardial adipose and ascending aorta tissue samples were obtained from 10 metabolic syndrome patients and 4 nonmetabolic syndrome patients during coronary bypass grafting and aortic valve replacement therapy, respectively. Fatty-acid-binding protein 4 gene expression was determined by quantitative real-time polymerase chain reaction. RESULTS AND CONCLUSIONS: Fatty-acid-binding protein 4 expression of epicardial adipose tissue was significantly higher in metabolic syndrome patients than in nonmetabolic syndrome controls (P<.05). In metabolic syndrome patients, fatty-acid-binding protein 4 expression in epicardial adipose tissue was 66 times higher than fatty-acid-binding protein 4 expression in ascending aorta tissue. The expression level of fatty-acid-binding protein 4 in epicardial adipose tissue was found to be significantly correlated with waist circumference in all subjects (r=.535, P<.05). Our data showed for the first time that human epicardial adipose and ascending aorta tissues express fatty-acid-binding protein 4 and that its level of expression in epicardial adipose tissues of metabolic syndrome patients is elevated. Increased fatty-acid-binding protein 4 gene expression in epicardial adipose tissues of metabolic syndrome patients led us think that fatty-acid-binding protein 4 might be an important factor in metabolic syndrome.


Asunto(s)
Tejido Adiposo/metabolismo , Proteínas de Unión a Ácidos Grasos/biosíntesis , Síndrome Metabólico/metabolismo , Pericardio/metabolismo , Aorta/metabolismo , Femenino , Expresión Génica , Humanos , Masculino , Persona de Mediana Edad , ARN Mensajero/análisis , Reacción en Cadena de la Polimerasa de Transcriptasa Inversa
20.
Echocardiography ; 24(10): 1090-2, 2007 Nov.
Artículo en Inglés | MEDLINE | ID: mdl-18001364

RESUMEN

Transesophageal echocardiography (TEE) has become a unique imaging technique that provides improved visualization of aorta because of its proximity to the esophagus. It is a reliable method for the diagnosis of thoracic aorta diseases and detection of protruding atheromas or thrombi as sources of systemic emboli. We report a case in which TEE revealed a floating aortic thrombus located in the ascending aorta in a patient with chronic renal failure.


Asunto(s)
Aorta Torácica , Ecocardiografía Transesofágica/métodos , Trombosis/diagnóstico por imagen , Anciano , Resultado Fatal , Femenino , Estudios de Seguimiento , Humanos , Trombectomía/métodos , Trombosis/cirugía
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