Integrative analysis of RNA expression data unveils distinct cancer types through machine learning techniques.

Cancer is a highly complex and heterogeneous disease. Traditional methods of cancer classification based on histopathology have limitations in guiding personalized prognosis and therapy. Gene expression profiling provides a powerful approach to unraveling molecular intricacies and better-stratifying cancer subtypes. In this study, we performed an integrative analysis of RNA sequencing data from five cancer types - BRCA, KIRC, COAD, LUAD, and PRAD. A machine learning workflow consisting of dataset identification, normalization, feature selection, dimensionality reduction, clustering, and classification was implemented. The k-means algorithm was applied to categorize samples into distinct clusters based solely on gene expression patterns. Five unique clusters emerged from the unsupervised machine learning based analysis, significantly correlating with the known cancer types. BRCA aligned predominantly with one cluster, while COAD spanned three clusters. KIRC was represented within two main clusters. LUAD is associated strongly with a single cluster and PRAD with another cluster. This demonstrates the ability of machine learning approaches to unravel complex signatures within transcriptomic profiles that can delineate cancer subtypes. The proposed study highlights the potential of integrative analytics to derive meaningful biological insights from high-dimensional omics datasets. Molecular subtyping through machine learning clustering enhances our understanding of the intrinsic heterogeneities and pathways dysregulated in different cancers. Overall, this study exemplifies a powerful computational framework to classify gene expressions of patients having different types of cancers and guide personalized therapeutic decisions. Finally, Wide Neural Network demonstrates a significantly higher accuracy, achieving 99.834% on the validation set and an even more impressive 99.995% on the test set.

Public's Mental Health Monitoring via Sentimental Analysis of Financial Text Using Machine Learning Techniques.

Public feelings and reactions associated with finance are gaining significant importance as they help individuals, public health, financial and non-financial institutions, and the government understand mental health, the impact of policies, and counter-response. Every individual sentiment linked with a financial text can be categorized, whether it is a headline or the detailed content published in a newspaper. The Guardian newspaper is considered one of the most famous and the biggest websites for digital media on the internet. Moreover, it can be one of the vital platforms for tracking the public's mental health and feelings via sentimental analysis of news headlines and detailed content related to finance. One of the key purposes of this study is the public's mental health tracking via the sentimental analysis of financial text news primarily published on digital media to identify the overall mental health of the public and the impact of national or international financial policies. A dataset was collected using The Guardian application programming interface and processed using the support vector machine, AdaBoost, and single layer convolutional neural network. Among all identified techniques, the single layer convolutional neural network with a classification accuracy of 0.939 is considered the best during the training and testing phases as it produced efficient performance and effective results compared to other techniques, such as support vector machine and AdaBoost with associated classification accuracies 0.677 and 0.761, respectively. The findings of this research would also benefit public health, as well as financial and non-financial institutions.

InteliRank: A Four-Pronged Agent for the Intelligent Ranking of Cloud Services Based on End-Users' Feedback.

Cloud Computing (CC) provides a combination of technologies that allows the user to use the most resources in the least amount of time and with the least amount of money. CC semantics play a critical role in ranking heterogeneous data by using the properties of different cloud services and then achieving the optimal cloud service. Regardless of the efforts made to enable simple access to this CC innovation, in the presence of various organizations delivering comparative services at varying cost and execution levels, it is far more difficult to identify the ideal cloud service based on the user's requirements. In this research, we propose a Cloud-Services-Ranking Agent (CSRA) for analyzing cloud services using end-users' feedback, including Platform as a Service (PaaS), Infrastructure as a Service (IaaS), and Software as a Service (SaaS), based on ontology mapping and selecting the optimal service. The proposed CSRA possesses Machine-Learning (ML) techniques for ranking cloud services using parameters such as availability, security, reliability, and cost. Here, the Quality of Web Service (QWS) dataset is used, which has seven major cloud services categories, ranked from 0-6, to extract the required persuasive features through Sequential Minimal Optimization Regression (SMOreg). The classification outcomes through SMOreg are capable and demonstrate a general accuracy of around 98.71% in identifying optimum cloud services through the identified parameters. The main advantage of SMOreg is that the amount of memory required for SMO is linear. The findings show that our improved model in terms of precision outperforms prevailing techniques such as Multilayer Perceptron (MLP) and Linear Regression (LR).

Edge Caching in Fog-Based Sensor Networks through Deep Learning-Associated Quantum Computing Framework.

Fog computing (FC) based sensor networks have emerged as a propitious archetype for next-generation wireless communication technology with caching, communication, and storage capacity services in the edge. Mobile edge computing (MEC) is a new era of digital communication and has a rising demand for intelligent devices and applications. It faces performance deterioration and quality of service (QoS) degradation problems, especially in the Internet of Things (IoT) based scenarios. Therefore, existing caching strategies need to be enhanced to augment the cache hit ratio and manage the limited storage to accelerate content deliveries. Alternatively, quantum computing (QC) appears to be a prospect of more or less every typical computing problem. The framework is basically a merger of a deep learning (DL) agent deployed at the network edge with a quantum memory module (QMM). Firstly, the DL agent prioritizes caching contents via self organizing maps (SOMs) algorithm, and secondly, the prioritized contents are stored in QMM using a Two-Level Spin Quantum Phenomenon (TLSQP). After selecting the most appropriate lattice map (32 × 32) in 750,000 iterations using SOMs, the data points below the dark blue region are mapped onto the data frame to get the videos. These videos are considered a high priority for trending according to the input parameters provided in the dataset. Similarly, the light-blue color region is also mapped to get medium-prioritized content. After the SOMs algorithm's training, the topographic error (TE) value together with quantization error (QE) value (i.e., 0.0000235) plotted the most appropriate map after 750,000 iterations. In addition, the power of QC is due to the inherent quantum parallelism (QP) associated with the superposition and entanglement principles. A quantum computer taking "n" qubits that can be stored and execute 2 n presumable combinations of qubits simultaneously reduces the utilization of resources compared to conventional computing. It can be analyzed that the cache hit ratio will be improved by ranking the content, removing redundant and least important content, storing the content having high and medium prioritization using QP efficiently, and delivering precise results. The experiments for content prioritization are conducted using Google Colab, and IBM's Quantum Experience is considered to simulate the quantum phenomena.

Estimation of Organizational Competitiveness by a Hybrid of One-Dimensional Convolutional Neural Networks and Self-Organizing Maps Using Physiological Signals for Emotional Analysis of Employees.

The theory of modern organizations considers emotional intelligence to be the metric for tools that enable organizations to create a competitive vision. It also helps corporate leaders enthusiastically adhere to the vision and energize organizational stakeholders to accomplish the vision. In this study, the one-dimensional convolutional neural network classification model is initially employed to interpret and evaluate shifts in emotion over a period by categorizing emotional states that occur at particular moments during mutual interaction using physiological signals. The self-organizing map technique is implemented to cluster overall organizational emotions to represent organizational competitiveness. The analysis of variance test results indicates no significant difference in age and body mass index for participants exhibiting different emotions. However, a significant mean difference was observed for the blood volume pulse, galvanic skin response, skin temperature, valence, and arousal values, indicating the effectiveness of the chosen physiological sensors and their measures to analyze emotions for organizational competitiveness. We achieved 99.8% classification accuracy for emotions using the proposed technique. The study precisely identifies the emotions and locates a connection between emotional intelligence and organizational competitiveness (i.e., a positive relationship with employees augments organizational competitiveness).

Boosting Breast Cancer Detection Using Convolutional Neural Network.

Breast cancer forms in breast cells and is considered as a very common type of cancer in women. Breast cancer is also a very life-threatening disease of women after lung cancer. A convolutional neural network (CNN) method is proposed in this study to boost the automatic identification of breast cancer by analyzing hostile ductal carcinoma tissue zones in whole-slide images (WSIs). The paper investigates the proposed system that uses various convolutional neural network (CNN) architectures to automatically detect breast cancer, comparing the results with those from machine learning (ML) algorithms. All architectures were guided by a big dataset of about 275,000, 50 × 50-pixel RGB image patches. Validation tests were done for quantitative results using the performance measures for every methodology. The proposed system is found to be successful, achieving results with 87% accuracy, which could reduce human mistakes in the diagnosis process. Moreover, our proposed system achieves accuracy higher than the 78% accuracy of machine learning (ML) algorithms. The proposed system therefore improves accuracy by 9% above results from machine learning (ML) algorithms.

Measuring and Preventing COVID-19 Using the SIR Model and Machine Learning in Smart Health Care.

COVID-19 presents an urgent global challenge because of its contagious nature, frequently changing characteristics, and the lack of a vaccine or effective medicines. A model for measuring and preventing the continued spread of COVID-19 is urgently required to provide smart health care services. This requires using advanced intelligent computing such as artificial intelligence, machine learning, deep learning, cognitive computing, cloud computing, fog computing, and edge computing. This paper proposes a model for predicting COVID-19 using the SIR and machine learning for smart health care and the well-being of the citizens of KSA. Knowing the number of susceptible, infected, and recovered cases each day is critical for mathematical modeling to be able to identify the behavioral effects of the pandemic. It forecasts the situation for the upcoming 700 days. The proposed system predicts whether COVID-19 will spread in the population or die out in the long run. Mathematical analysis and simulation results are presented here as a means to forecast the progress of the outbreak and its possible end for three types of scenarios: "no actions," "lockdown," and "new medicines." The effect of interventions like lockdown and new medicines is compared with the "no actions" scenario. The lockdown case delays the peak point by decreasing the infection and affects the area equality rule of the infected curves. On the other side, new medicines have a significant impact on infected curve by decreasing the number of infected people about time. Available forecast data on COVID-19 using simulations predict that the highest level of cases might occur between 15 and 30 November 2020. Simulation data suggest that the virus might be fully under control only after June 2021. The reproductive rate shows that measures such as government lockdowns and isolation of individuals are not enough to stop the pandemic. This study recommends that authorities should, as soon as possible, apply a strict long-term containment strategy to reduce the epidemic size successfully.