RESUMEN
BACKGROUND AND AIMS: Our recent data document that a low glycemic index (LGI) Neapolitan pizza prepared with a mix of Kamut and whole wheat flours plus Glucomannan, (i) has a lower impact on postprandial hyperglycemic spikes than pizza made of whole wheat flour, (ii) is pleasant and appreciated as traditional one and (iii) does not cause any gastro-intestinal troubles. The aim of our study was to describe the validation process underlying the identification of the right mix of those elements for a LGI pizza preventing gastro-intestinal disturbances. METHODS: we described all procedures followed to make good products with different combinations of the three components and a series of tests made by four well-experienced professional pasta-making masters, one nutritionist, five diabetologists, one nurse and twenty volunteers with T1DM. RESULTS: we could identify the best workable and most suitable flour mix to achieve both pleasant taste and low glycemic impact proving to be efficient in real-life twin paper providing results from diabetic patients. CONCLUSIONS: this kind of food will certainly help people with diabetes eat pizza without risking any serious deterioration of their own glucose control while fully enjoying socially active life.
Asunto(s)
Diabetes Mellitus/metabolismo , Fibras de la Dieta/análisis , Harina/análisis , Tracto Gastrointestinal/metabolismo , Índice Glucémico , Triticum/química , Glucemia/análisis , Diabetes Mellitus/patología , Harina/efectos adversos , Tracto Gastrointestinal/patología , Humanos , Periodo PosprandialRESUMEN
Opposed to whole wheat (WWP), traditional pizza (TP) is loved by patients with type 1 diabetes mellitus (T1DM) despite causing hyperglycemia. 50 well-trained T1DM patients had higher glucose levels after TP than after WWP or mixed flour pizza, which however was tasty, digestible and metabolically appropriate to break diet monotony.
Asunto(s)
Diabetes Mellitus Tipo 1/dietoterapia , Índice Glucémico , Hipoglucemiantes/uso terapéutico , Sistemas de Infusión de Insulina , Insulina/uso terapéutico , Gusto , Adolescente , Adulto , Glucemia/análisis , Diabetes Mellitus Tipo 1/tratamiento farmacológico , Carbohidratos de la Dieta , Fibras de la Dieta , Femenino , Humanos , Hipoglucemiantes/administración & dosificación , Insulina/administración & dosificación , Masculino , Persona de Mediana Edad , Resultado del Tratamiento , Adulto JovenRESUMEN
Ex novo Kaposi's Sarcoma 4 months after renal transplantation in a young patient is described. Progression of the tumoral lesions has been observed during combined immunosuppressive treatment with Prednisone, Azathioprine and Cyclosporin. Stopping Azathioprine and Cyclosporin as well as reducing Prednisone prevented new lesions and made the preexistent skin lesions less extensive. Clinical case, possible pathogenesis and therapeutic strategies are discussed.
Asunto(s)
Inmunosupresores/efectos adversos , Trasplante de Riñón , Sarcoma de Kaposi/inducido químicamente , Neoplasias Cutáneas/inducido químicamente , Adulto , Humanos , Masculino , Sarcoma de Kaposi/patología , Neoplasias Cutáneas/patologíaRESUMEN
The effects of chronic administration of L-carnitine were evaluated by EMG analysis in 20 uraemic patients undergoing periodical haemodialysis (mean duration of dialysis 34.7 months). No important changes in motor conduction velocity or distal latency of the external popliteal nerve were found after the treatment, while a reduction in the number of polyphasic muscle action potentials was observed. After carnitine administration, an increase of total EMG power was noted and the spectral array showed a progressive shift towards lower frequencies in 8 patients who had shown higher values. These results suggest that carnitine has a prevalent "myotrophic" effect.