Synthesis and improved optical, electrical, and dielectric properties of PEO/PVA/CuCo2O4 nanocomposites.

This study investigates the development of novel nanocomposite films based on a blend of polyethylene oxide (PEO) and polyvinyl alcohol (PVA) loaded with varying weight percentages of copper cobaltite nanoparticles (CuCo2O4 NPs). The primary objective was to fabricate these nanocomposites using a solution casting technique and explore the influence of CuCo2O4 content on their structural, optical, electrical, and dielectric properties. Spinel-type CuCo2O4 NPs were synthesized via the hydrothermal method and incorporated into the PEO/PVA blend. X-ray diffraction (XRD) analysis revealed the transformation of the polymer matrix towards an amorphous state with increasing CuCo2O4 content. UV-Vis spectroscopy studies demonstrated a decrease in both the direct and indirect band gaps of the nanocomposites, suggesting potential applications in optoelectronic devices. Impedance spectroscopy measurements revealed a significant enhancement in ionic conductivity (three orders of magnitude higher than the pristine blend) for the nanocomposite film containing 1.8 wt% CuCo2O4. The real permittivity (ε') and imaginary permittivity (ε″) of the polymer nanocomposites exhibited a decrease with increasing frequency due to the interplay of various polarization mechanisms. Notably, incorporating 1.8 wt% CuCo2O4 nanoparticles led to a remarkable improvement in energy density compared to the pristine blend. Additionally, a significant decrease in the potential barrier was observed. These findings demonstrate the successful fabrication of PEO/PVA-CuCo2O4 nanocomposite films with enhanced optical, electrical, and dielectric properties. The observed improvements suggest promising applications for these materials in energy storage devices and potentially in optoelectronic devices like light-emitting diodes.

Long-term gastrointestinal adverse effects of doxycycline.

INTRODUCTION: Doxycycline is an antibiotic with known gastrointestinal (GI) adverse effects. Esophagitis is the most pronounced among these effects, and might be associated with a prolonged duration of therapy. The aim of this study is to evaluate the incidence of esophagitis and other GI side effects in adults who received doxycycline for at least a month. METHODOLOGY: This retrospective descriptive study included adults who received oral doxycycline for at least one month between 2016 and 2018. The primary outcome was the frequency of esophagitis. The secondary outcomes were frequency of and discontinuation due to GI adverse effects. RESULTS: A total of 189 subjects were included with a median age of 32 years. The median duration of doxycycline use was 44 days (interquartile range 30-60). Twelve patients (6.3%) reported having GI adverse effects resulting in doxycycline discontinuation in five of them (2.6%), and three patients (1.6%) had esophagitis. The incidence of GI adverse effects was significantly higher in patients who were ≥ 50 years than < 50 years old (8/50 vs. 4/139; p = 0.003) and in those who received a daily dose of 200 mg than 100 mg (12/93 vs. 0/96; p < 0.001). CONCLUSIONS: GI adverse events, including esophagitis, are not rare with long-term use of oral doxycycline, particularly in older age and a higher dose of 200 mg/day. Future large and randomized studies are needed to compare the efficacy and safety of different doxycycline doses.

Review on PEDOT:PSS-Based Conductive Fabric.

This article reviews conductive fabrics made with the conductive polymer poly(3,4-ethylenedioxythiophene):poly(styrenesulfonate) (PEDOT:PSS), their fabrication techniques, and their applications. PEDOT:PSS has attracted interest in smart textile technology due to its relatively high electrical conductivity, water dispersibility, ease of manufacturing, environmental stability, and commercial availability. Several methods apply PEDOT:PSS to textiles. They include polymerization of the monomer, coating, dyeing, and printing methods. In addition, several studies have shown the conductivity of fabrics with the addition of PEDOT:PSS. The electrical properties of conductive textiles with a certain sheet resistance can be reduced by several orders of magnitude using PEDOT:PSS and polar solvents as secondary dopants. In addition, several studies have shown that the flexibility and durability of textiles coated with PEDOT:PSS can be improved by creating a composite with other polymers, such as polyurethane, which has high flexibility and extensibility. This improvement is due to the stronger bonding of PEDOT:PSS to the fabrics. Sensors, actuators, antennas, interconnectors, energy harvesting, and storage devices have been developed with PEDOT:PSS-based conductive fabrics.

Rapid antigen detection test (RADT) for pharyngitis diagnosis in children: Public and pharmacist perception.

BACKGROUND: Most common sought antibiotic-self treated infection globally is pharyngitis (sore throat). The aim of this study is to assess public's acceptance and potential use of Rapid Antigen Detection Test at community pharmacies in the diagnosis of bacterial pharyngitis in children prior to antibiotic dispensing in Saudi Arabia. METHOD: A qualitative cross-sectional study was conducted on October 2017. Two self-conducted questionnaires were used. One targeted the public above 21 years old and was distributed via social media. The other randomly targeted community pharmacists in Jeddah. RESULT: A total of 689 of the public and 40 community pharmacists completed the survey. Moreover, 571 (82.9%) of the public received antibiotics without a prescription; for symptoms related to sore throat (71%) followed by flu-like symptoms (24%). Only (3.77%) and (5%) of both public and community pharmacies have heard about RADT respectively, however the majority (93.03%) and (90%) of both respectively support its use in community pharmacies. Coded reasons for its use was mainly to decrease antibiotic misuse and/or abuse, increased specificity, decreased antibiotic side effects including bacterial resistance, and ease of use. CONCLUSION: Both public and community pharmacists support the idea of using RADT. Future efforts should look into pharmacist's role in providing point of care tests that are cost-effective and convenient for the public.