Knowledge and Preventive Practice on COVID-19 among Civil Employees Working In Selected Unit of Dhaka Cantonment.

Corona viruses are a large group of viruses that are responsible for sickness starting from mild common cold to extremely severe form of diseases. Prevention is the best method to control COVID-19 pandemic. The World Health Organization recommended that generating awareness by enriching knowledge of people to rule out COVID-19. To find out the level of knowledge and status of preventive practice on COVID-19 among Civil employees of Central Ordnance Depot (COD) and Central Mechanical Transport Depot (CMTD) of Dhaka Cantonment. This descriptive cross-sectional study was conducted among 151 civil employees of COD (Central Ordnance Depot) and CMTD (Central Mechanical Transport Depot), Dhaka cantonment from July 2020 to June 2021. Systematic random sampling technique was used to select the respondents. Data collection was done by face to face interview with using semi-structured questionnaire. The mean age of the respondent was 37.94±10.12 years. Among the respondents 84.8% were male, rest 15.2% were female. Mean score of knowledge highest (17.73) in 18-29 years age group, in female (17.83), 2nd class employee (18.00) and those qualified in graduation and above (17.27). Regarding level of knowledge 77.48% respondents had excellent knowledge, of which most of them were doing practice. The association between knowledge and preventive practice of COVID-19 on hand washing (p=0.01), wearing face mask (p=0.000), maintaining social distance (p=0.002) were found statistically significant. In this study most of the respondents had 'excellent' and 'good' level of knowledge on COVID-19, of which most of them were doing practice. There are some, those who had knowledge but not doing practice. On the other hand some had no knowledge on particular event of COVID-19, but were doing practice unknowingly.

Characterization of ß-lactamase and quinolone resistant Clostridium perfringens recovered from broiler chickens with necrotic enteritis in Bangladesh.

BACKGROUND: Clostridium perfringens causes necrotic enteritis (NE) and is considered a major economic burden in the broiler industry and a significant foodborne pathogen, worldwide. AIMS: Clostridium perfringens isolated from NE affected broiler chickens was aimed to characterize and the presence of ß-lactamase and quinolone resistant genes were also investigated in the isolates. METHODS: A total of 224 intestinal and caecal specimens were collected from NE affected broiler chickens and cultured to isolate C. perfringens. The toxicogenic characterization of C. perfringens was appraised using polymerase chain reaction (PCR) and antibiotic susceptibility testing (disc diffusion method). The selected C. perfringens isolates were characterized for ß-lactamase and quinolone encoding genes by PCR analysis. RESULTS: All isolates were cultured positive for C. perfringens and the toxin-encoding genes of C. perfringens (α-, ß-, ß2-, ε-, ι-, and enterotoxin) were also identified. About 65.6% of isolates had a multi-drug resistant (MDR) profile but none of these isolates were resistant or susceptible to all screened antibiotics. A subset of isolates, 160 and 98 were analyzed for ß-lactamase and quinolone genes, respectively, and recognized bla TEM, bla SHV, and bla OXA in 64 (40%; CI: 32.35-48.03%; P<0.001) isolates, and qnrB and qnrS in 28 (28.57%; CI: 19.90-38.58%; P<0.001) isolates except qnrA. CONCLUSION: Therefore, the isolates of C. perfringens were toxicogenic and carried ß-lactamase, and quinolone resistance genes. Nowadays, the rational use of antibiotics and safe production of broiler chickens are the major concern to save public health.

Non-syndromic craniosynostosis treated by frontal orbital advancement: A case report.

Craniosynostosis is a premature pathologic fusion of one or more cranial vault sutures leading to abnormally-shaped skull. It can occur in isolated event (non-syndromic), or it can occur in conjunction with other anomalies in welldefined patterns (syndromic). The diagnosis rests on clinical examination and confirmation is generally on the computed tomography scan. The need for surgery is both for cosmetic and functional reasons. Here we describe a case of nonsyndromic craniosynostosis that was treated with frontal orbital advancement (FOA). The potential benefits of FOA need to be carefully weighed against the potential complications when deciding for any surgical intervention.

Effects of sustained-release trimetazidine on chronically dysfunctional myocardium of ischemic dilated cardiomyopathy - Six months follow-up result.

BACKGROUND: Ischemic cardiomyopathy is a growing burden in third world countries. So far, benefits of trimetazidine in this group of patients have been suggested by clinical trials mainly conducted in Europe. We evaluated the effect of trimetazidine on ischemic dilated cardiomyopathy in our population. METHODS AND RESULTS: 98 patients (aged 58.5±9.2 years), admitted with decompensated heart failure with previous history of MI and/or documentation of significant CAD with previous CAG, were chosen for the study. Patients were randomized into two groups - one provided with trimetazidine 35mg sustained released tablet, twice daily and the other with a placebo, along with other conventional medications. Patients were included if they had dilated LV (LVIDd>57mm) and left ventricular ejection fraction (LVEF) ≤40%. After 6 months, significantly higher number of patients in trimetazidine group were in NYHA class I (22% vs. 8%, p=0.03) and class II (56% vs. 34%, p=0.01); higher number of patients in placebo group were in NYHA class III class IV. Anginal episodes and use of sublingual nitrate per week were significantly lower in the trimetazidine group. Left ventricular diastolic dimension (59.7±5.2 vs. 65.1±6.1, p=0.001) was significantly different in the two groups as was the increase of LVEF (11% vs. 5.6%, p=0.001). Hospitalization for worsening heart failure was significantly lower in trimetazidine group (13 vs. 22, p=0.047). CONCLUSION: Trimetazidine seems to be beneficial in patients with ischemic dilated cardiomyopathy in South Asian population and larger scale study with extended follow-up is needed.

A meta-analysis of the relative efficacy and toxicity of single daily dosing versus multiple daily dosing of aminoglycosides.

We performed a meta-analysis of the efficacy and toxicity of single daily dosing (SDD) vs. multiple daily dosing of aminoglycosides and summarized the results of the four previously published meta-analyses on this subject. Our analysis showed that the overall clinical response rate favored SDD therapy (mean difference, +3.06%; 95% confidence limit [CL], +0.17% to +5.95%; P = .04). However, we found no significant difference in the overall microbiological response rates (mean difference, +1.25%; 95% CL, -0.40% to +2.89%) or in the clinical response rates (mean difference, +0.62%; 95% CL, -2.48% to +3.71%) when patients who received adjunctive antimicrobial therapy were excluded from the analysis. No significant differences were found in the incidences of nephrotoxicity, ototoxicity, or vestibular toxicity; the summary differences in the rates of these toxicities were -0.18% (95% CL, -2.17% to +1.81%), +1.38% (95% CL, -0.99% to +3.75%), and -3.05% (95% CL, -10.69% to +4.59%), respectively. These results are similar to those of the previously published meta-analyses.

Detection of antibacterial substances in some plant residues and their effect on certain micro-organisms.

The effect of dry residues from several plants, belonging to different families on certain microorganisms in vitro and in vivo, was studied. Dry residues of paprica leaves, tomato tops, egg plant leaves, guava leaves, onion peels, garlic tops, wheat straw, sugar cane leaves, cotton leaves, Egyptian clover tops, field bean tops or pea tops were examined for the presence of antibacterial substances, using successive extractions with hexane, ethyl ether, ethanol, and water, respectively, for each plant residue. On culture media, the antibacterial effect, expressed as width of inhibition zones, differed according to the type of plant, type of micro-organism, and extraction medium, used for each plant. Water extract from each of the studied plants showed no effect on any of the studied micro-organisms, while the other extracts indicated the presence of antibacterial substances in all the used plants. In most cases, ether extract showed the highest incidence of antimicrobial activities against the majority of test micro-organisms. In general, the antibacterial substances seemed to be more inhibitory to Gram-positive bacteria than to Gram-negative ones. Ethyl-ether extract of the residues of most of these plants markedly affected the growth of more than one of the different Rhizobium species when grown on culture medium, as indicated by the presence of wide zones of inhibition.