RESUMEN
Epilepsy is one of the most studied chronic neurological disorders in the world. Despite significant progress in epilepsy research, some patients continue to experience recurrent seizures. It has been proven that oxidative stress plays an important role in epilepsy. Targeting oxidative stress may provide a novel therapeutic intervention to attenuate epileptogenesis as well as cognitive and psychiatric impairment in patients with epilepsy. One of the promising directions in the search for new strategies for the treatment of epilepsy is the combined use of antiepileptic drugs with antioxidants that affect the pathogenetic links of this disease. The new Russian antiepileptic drug fenosanoic acid (Dibufelon) has an anticonvulsant effect due to the inhibition of lipid peroxidation of brain cells and the reconstruction of cell membranes. This mechanism of action also paves the way for an increase in the effectiveness of co-administered drugs with phenosanoic acid. The effect of the drug on the cognitive and mental functions of patients, the regression of asthenia phenomena is also observed. The clinical efficacy and safety of the combination of this drug with other antiepileptic drugs in epilepsy has been demonstrated in experimental and clinical studies.
Asunto(s)
Anticonvulsivantes , Epilepsia , Humanos , Anticonvulsivantes/uso terapéutico , Anticonvulsivantes/farmacología , Epilepsia/tratamiento farmacológico , Epilepsia/metabolismo , Convulsiones/tratamiento farmacológico , Antioxidantes/farmacología , Estrés OxidativoRESUMEN
The results of investigation of endocrinal and containing serotonin cells in gastric and rectal mucosa in 48 patients in nonspecific ulcerative colitis (NUC), are presented. In accordance to histochemical and immunohistochemical investigations, quantity of endocrinal cells and those, containing serotonin, in gastric and rectal mucosa is reducing, persistence of these changes depends on NUC severity.
