1.
Chem Pharm Bull (Tokyo)
; 65(10): 989-993, 2017.
Artículo
en Inglés
| MEDLINE
| ID: mdl-28966283
RESUMEN
Chiral phosphine oxide sequentially activates silicon tetrachloride and trichlorosilyl enol ethers to facilitate asymmetric aldol/vinylogous aldol reaction of 4-methoxy-3-penten-2-one and conjugated aldehydes in a highly enantioselective fashion, and the subsequent cyclization produced optically active 2,6-disubstituted 2,3-dihydro-4-pyranones bearing stereogenic centers at a remote position in a single operation.