Biosynthesis of palladium, platinum, and their bimetallic nanoparticles using rosemary and ginseng herbal plants: evaluation of anticancer activity.

In this research, palladium (II) and platinum (II), as well as their bimetallic nanoparticles were synthesized using medicinal plants in an eco-friendly manner. Rosemary and Ginseng extracts were chosen due to their promising anticancer potential. The synthesized nanoparticles underwent characterization through FT-IR spectroscopy, DLS, XRD, EDX, SEM, and TEM techniques. Once the expected structures were confirmed, the performance of these nanoparticles, which exhibited an optimal size, was evaluated as potential anticancer agents through in vitro method on colon cancer cell lines (Ls180, SW480). MTT assay studies showed that the synthesized nanoparticles induced cell death. Moreover, real-time PCR was employed to investigate autophagy markers and the effect of nanoparticles on the apoptosis process, demonstrating a significant effect of the synthesized compounds in this regard.

Synthesis, crystal structure and spectroscopic studies of copper complexes with tridentate Schiff base ligand.

Four Cu(II) complexes [CuLX], where X = NO3 (1), Br (2), Cl (3), ClO4 (4) and L = benzoylacetonacetohydrazid tridentate Schiff base, HL, have been synthesized and characterized by elemental analysis, FT-IR, UV-Vis spectroscopy. The structure of compound 1, has been determined by single-crystal X-ray diffraction analysis. The structure of 1 is a mononuclear species, the coordination geometry around the copper(II) ion is four coordinated square planar, L acts as a tridentate ligand which forms one five-membered and one six-membered chelate rings with the Cu(II) metal center, and the fourth position at the Cu ion is occupied by the NO3 anion. The nitrate ions play role in the H bonding network. In fact the amide NH groups act as H donor towards the nitrate oxygen. The formation of the copper complexes in solution was monitored by a UV/Vis titration experiment. The results revealed that the complexes were of the composition (ligand/metal) 1:1 in solution.