A novel methodology for analysis of enantiomers through determination of their critical micelle concentrations using spectrophotometric method.

A novel methodology for analysis of enantiomer composition of chiral compounds based on measuring of their critical micelle concentration by using spectrophotometric technique is introduced. The proposed method does not require any chiral selector and the corresponding process is simple, fast, reproducible, and inexpensive. The procedure was successfully applied for analysis of naproxen. The critical micelle concentration data showed that (R)-naproxen could be determined with an RSD of 1.1% and a relative error of -5.6% when a real sample containing the racemic mixture of naproxen with a total concentration of 0.04 mM was tested.