Sincronização da ovulação utilizando FSH em substituição à eCG em cabras / Ovulation synchronization using FSH replacing eCG in goats

The effect of substitution of equine chorionic gonadotropin (eCG) by follicle stimulating hormone (FSH) in synchronization protocols of ovulation in dairy goats was evaluated. Twelve goats received intravaginal sponges impregnated with 60mg of medroxyprogesterone acetate (MAP) for 10 days. The sponges were removed and the animals were distributed into two groups (G): G1 (n=6) treated with 0.5mL of a synthetic analogue of PGF2 α and 100 IU of eCG for each 10kg weight, intramuscular injection (IM); and G2 (n=6) treated with 0.5mL of a synthetic analogue of PGF2α and 20mg of FSH (IM). All animals were monitored for estrus detection with aid of a ruffian after sponge removal. The ovarian dynamics were analyzed by ultrasound, since six hours after sponge removed. Each animal was analyzed in time elapsed of six hours until 12 hours after ovulation detection. For data analyses, the Wilcoxon test and variance analyses were used. There was not difference between the analyzed parameters (P>0.05). In this way, eCG can be replaced by FSH in synchronization protocols of ovulation in dairy goats.

Morphometric studies of specific brain regions of rats chronically intoxicated with the organophosphate methamidophos.

Subtle neurological disturbances have been described in organophosphorus intoxication. Experimental studies have reported neuronal necrosis, particularly in animals experiencing seizures. The objective of the present work was to investigate if in rats (without seizures) exposed to an organophosphate agent, morphological changes occur in specific regions of the brain. The animals received 2.5 or 5.0 mg/kg methamidophos once a week for 2 months and were decapitated after 2 months 7 days of drug administration. We observed atrophy of the molecular layer of the parietal cortex without neuronal loss in specific cerebral regions. This would be due to atrophy or loss of neuronal ramifications but without neuronal loss.

Menière's syndrome and migraine: incidence in one family.

Since 1992, we have applied a standard questionnaire to all our Meniere's syndrome patients. We ask about other family members affected by the symptoms and about the presence of the usual migraine symptom. Through this questionnaire we have identified a family that has some members affected by Meniere's syndrome alone, some others with associated migraine, and still others with migraine alone. Two members of this family started out with migraine and later in life developed Meniere's syndrome. The genetic transmission follows an autosomal dominant pattern for both Meniere's syndrome and migraine. We have interviewed and studied 19 affected persons from several generations of this family, who form the basis of this report. The possibility of a common autosomal dominant genetic determinant for Meniere's syndrome and migraine and its implications for the causation of Meniere's disease are discussed.