Tissue Regeneration on Rise: Dental Hard Tissue Regeneration and Challenges-A Narrative Review.

Background: As people live longer, there is an increasing need for hard tissue regeneration and whole-tooth regeneration. Despite the advancements in the field of medicine, the field of regenerative dentistry is still challenging due to the complexity of dental hard tissues. Cross-disciplinary collaboration among material scientists, cellular biologists, and odontologists aimed at developing strategies and uncovering solutions related to dental tissue regeneration. Methodology. A search of the literature was done for pertinent research. Consistent with the Preferred Reporting Items for Systematic Review and Meta-Analysis (PRISMA) 2020 Statement, the electronic databases looked at were PubMed, Science Direct, Scopus, and Google Scholar, with the keyword search "hard dental tissue regeneration." Results: Database analysis yielded a total of 476 articles. 222 duplicate articles have been removed in total. Articles that have no connection to the directed regeneration of hard dental tissue were disregarded. The review concluded with the inclusion of four studies that were relevant to our research objective. Conclusion: Current molecular signaling network investigations and novel viewpoints on cellular heterogeneity have made advancements in understanding of the kinetics of dental hard tissue regeneration possible. Here, we outline the fundamentals of stem hard dental tissue maintenance, regeneration, and repair, as well as recent advancements in the field of hard tissue regeneration. These intriguing findings help establish a framework that will eventually enable basic research findings to be utilized towards oral health-improving medicines.

Clinical performance of immediately placed and immediately loaded single implants in the esthetic zone: A systematic review and meta-analysis.

OBJECTIVES: The aim of this study was to assess the following PIO question: In adult patients treated with an indication for single tooth extraction in the maxillary esthetic zone (15-25), what is the influence of an immediate implant placement and immediate loading protocol on the clinical performance (primary aim) and esthetic outcomes (secondary aim) focusing on investigations published after 2010. MATERIAL AND METHODS: An electronic search in Medline (PubMed), the Cochrane Central Register of Controlled Trials, and EMBASE databases up to April 2022 was performed to identify clinical studies investigating the outcome of single implants subjected to immediate placement with immediate restoration/loading (Type 1A). RESULTS: Sixty-three studies (10 randomized controlled trials, 28 prospective and 25 retrospective cohort studies) were included with a follow-up ranging from 12 to 96 months. One thousand nine hundred sixty-one implants reported survival rates of 99.2 (98.6-99.5) % at 1 year, 97.5 (95.9-98.4) % after 3 years, and 95.8 (93.3-97.4) % after 5 years; 1064 immediately loaded restorations presented survival rates of 98.9 (97.8-99.5) % after 1 year, 96.8 (93.6-98.4) % after 2 years, and 94.8 (89.6-97.4) % after 5 years. Comparing baseline to 12-month data using the Hedges' g effect size (95% CI), papilla height presented an overall effect size of -0.71 (-1.25, -0.1) mm, midfacial recession change of -0.15 (-0.66, 0.36) mm, and a 0.82 (0.37, 1.28) gain in PES. CONCLUSIONS: Immediate implant placement and immediate loading can be considered a predictable and safe treatment option for single maxillary anterior restorations with adequate survival rates and favorable esthetics outcomes for up to 5 years.

Salivary Biomarkers in Periodontitis: A Scoping Review.

Periodontal disease is a prevalent and potentially impactful oral health condition, ranging from gingivitis to severe periodontitis. Early detection and precise management are crucial in modern dentistry due to its prevalence and potential systemic health implications. Traditional clinical assessments and radiographic imaging have been the primary diagnostic tools. However, recent advances in oral diagnostics have introduced the concept of non-invasive, easily accessible salivary biomarkers. This review explores the evolving landscape of salivary biomarkers associated with periodontal disease, offering a comprehensive analysis of recent studies. It delves into the key findings, clinical significance, and potential impact of these biomarkers in revolutionizing periodontal disease diagnostics and treatment monitoring. The study emphasizes their diagnostic and prognostic capabilities, including their ability to assess disease severity, correlate with clinical parameters, aid in early detection, and enhance personalized treatment planning. As the field of oral diagnostics continues to advance, understanding the role of salivary biomarkers in periodontal disease management holds the promise of improving precision and effectiveness in oral healthcare. This review underscores the potential for salivary biomarkers to become integral components of routine periodontal care, offering a minimally invasive and patient-centered approach to oral health management.

Digitally Fabricated Provisional Implant Restorations Prior to Implant Placement: A Clinical Case Series.

PURPOSE: To review the factors that affect the ability to deliver a CAD/CAM implant-supported provisional restoration designed from a virtually planned implant position prior to surgical placement with static computer-assisted implant surgery (sCAIS). MATERIALS AND METHODS: Data were collected on patients treated with single-tooth implant treatment in which CBCT was combined with intraoral scans and imported into a virtual implant planning software. A synchronization tool established the connection between the planning software and the CAD software, where a digital diagnostic tooth arrangement was performed to create the ideal tooth dimensions and mucosal architecture. The virtual implant planning was finalized, and the implant position was transferred to the CAD software, where a restoration was designed and fabricated. The sCAIS was performed, and the prefabricated custom restorations were delivered on the day of the surgery or following healing if delayed loading or submerged healing was required. Descriptive statistics and statistical comparison with two-proportion z test were performed. RESULTS: A total of 23 patients with 28 single-implant sites met the inclusion criteria and were included in the study. Nineteen customized healing abutments and 10 provisional crowns were designed and fabricated for a total of 29 restorations. Of the restorations, 23 were successfully delivered on the day of the surgical intervention. No statistical significance was found among the different variables compared. CONCLUSION: Custom prefabricated CAD/CAM restorations based on a virtually planned implant position can be successfully designed, fabricated, and delivered when used in combination with sCAIS.

Tilted versus axial implant distribution in the posterior edentulous maxilla: A CBCT analysis.

OBJECTIVES: This study aimed to determine whether distally angulating an implant is a successful strategy to avoid the maxillary sinus and the need for bone augmentation, while increasing the anterior-posterior (A-P) implant distribution in the edentulous maxilla. MATERIALS AND METHODS: In 115 patients with edentulous maxillae, virtual implant planning was performed utilizing cone-beam computer tomographs. Axial (8 mm length) and tilted (12 mm length) dental implants with 30-degree and 45-degree angulation were virtually positioned to avoid entering the maxillary sinus, while maximizing A-P distribution. Measurements were made between the tilted and axial implants to assess the change in A-P distribution of implants at the implant and abutment levels. RESULTS: Forty-seven sites (20.4%) were not able to have either treatment modality with insufficient bone for implant placement. Axial implants were placed more distally than 45-degree and 30-degree tilted implants in 24% and 42% of sites, respectively. The average change in A-P spread measured at the implant level, for 30- and 45-degree tilted implants was -0.25 mm (95% CI -0.76, 0.26) and 1.9 mm (95% CI 1.4, 2.3), respectively. When measured from the center of each multi-unit abutment the average increase in A-P distances for tilted implants appears larger in the 30-degree and 45-degree groups by 0.97 mm and 1.74 mm, respectively compared to measurements at the implant level. CONCLUSIONS: Angulating 12 mm implants provides a limited increase in A-P distribution of implants in edentulous rehabilitation in most situations. In certain patients, the use of 8mm axial implants may provide a greater A-P spread.

Effect of acidic pH on surface roughness of esthetic dental materials.

STATEMENT OF PROBLEM: Exposure to gastric acid in patients with bulimia nervosa and gastroesophageal reflux disease (GERD) causes demineralization of hard tooth structures. This chemical attack also causes the degradation of dental ceramics, which results in increased surface roughness and reduced strength. However, studies comparing the effect of acidic pH on resin matrix ceramic with other computer-aided design and computer-aided manufacturing (CAD-CAM) esthetic materials are lacking. PURPOSE: The purpose of this in vitro study was to compare the surface roughness changes of different CAD-CAM restorative dental materials after exposure to acidic pH by using a 3D optical interferometer. MATERIAL AND METHODS: Five esthetic CAD-CAM block materials, a leucite glass-ceramic (IPS Empress CAD), a zirconia (BruxZir Solid Zirconia), a resin matrix ceramic (VITA Enamic), a lithium disilicate glass-ceramic (IPS e.max CAD), and a feldspathic porcelain (VITABLOCS Mark II CAD) were tested. Eighteen specimens were sectioned from CAD-CAM blocks into 2-mm-thick rectangular plates and immersed in 10 mL of 5% hydrochloric acid (HCl) with (pH=2) at 37 °C for 45 and 91 hours. The surface roughness average (Ra) of the specimens was measured by using a 3D optical interferometer before the storage period (baseline), after 45 hours, and after 91 hours of exposure to HCl. Statistical analyses were performed with the Kruskal-Wallis test and the post hoc Dunn test with Bonferroni correction (α=.05). RESULTS: Regarding the comparison of surface roughness changes at different periods of evaluation (baseline, 45 hours, 91 hours), there were no statistically significant differences for lithium disilicate (P=.063) or zirconia (P=.513). Leucite glass-ceramic, feldspathic porcelain, and the resin matrix ceramic demonstrated statistically significant differences (P<.001). For all tests that were statistically significant, greater surface roughness was found at the time point with the longer HCl exposure. Regarding the comparison of materials in terms of change in surface roughness between baseline to 45 hours and baseline to 91 hours, the Kruskal-Wallis test indicated a statistically significant difference among the materials in both cases (P<.001). Lithium disilicate and zirconia exhibited the least change in surface roughness among the 5 materials. CONCLUSIONS: Leucite glass-ceramic, feldspathic porcelain, and resin matrix ceramic showed statistically significant increases in surface roughness when they were exposed to simulated gastric acid for 45 and 91 hours. Lithium disilicate and zirconia showed no statistically significant change in surface roughness after exposure to HCl for 45 and 91 hours.