Fecal Carriage of Colibactin-Encoding Escherichia coli Associated With Colorectal Cancer Among a Student Populace.

Fecal carriage of the colibactin (clb) gene in Escherichia coli is described as a source that could promote carcinogenesis, progressing to colorectal cancer. The present study investigated the demographic, dietary, and antibiotic consumption variables as correlates for fecal carriage of clb+/E coli among the student populace. In a randomized cross-sectional survey, E coli (N = 136) from the fecal samples of eligible students were characterized and evaluated for antibiotic resistance, ß-lactamase (blm), biofilm, virulence factor production, and strain tryptophan reverse mutagenic activity. The encoded clb+/E coli were analyzed for correlates with principal component analysis. Of all the E coli strains, a low rate of 2 clb+/E coli (1.5%) and higher rates of biofilm (13.2%) and blm producers (11.8%) were recorded among the mutant strains as compared with the nonmutant types. All the clb+/E coli showed complete resistance to amoxicillin, Augmentin (amoxicillin and clavulanate), gentamicin, and trimethoprim/sulfamethoxazole. The fecal clb-encoded E coli (1.5%) were not associated with demographic status, fiber-based food (odds ratio [OR], 1.03; 95% CI, 56.74-138.7; P = .213), alcohol (OR, 1.27; 95% CI, 61.74-147.1; P = .221), antibiotic consumptions (OR, 1.11; 95% CI, 61.29-145.3; P = .222), and handwashing (OR, 1.17; 95% CI, 60.19-145.5; P = .216). The hierarchical cluster of blm+/E coli revealed high-level resistance with a multiantibiotic resistance index ≥0.2 (P < .05). Only 12% of all strains were tryptophan mutant/blm+, and 1.5% of clb+/ECblm+ were observed in fecal samples with a 452-base pair size. Trimethoprim/sulfamethoxazole and biofilm production positively regressed with clb expression (P > .05). Principal component analysis score plot indicated an association of clb+/ECblm+ with dietary pattern, alcohol, blm, and hemolysin production. The combined activity of blm and biofilm production in the gut microbiota could promote clb+/E coli colonization, facilitating genotoxin production and possible colorectal cancer induction.

To Save a Girl-Child, You Must Train a Boy-Child: A Note on Situational Irony.

Despite numerous initiatives and resources to save and protect the health and sexual rights of girls and women, the persistently high rate of unwanted pregnancy, abortion, and sexual violence in sub-Saharan Africa (SSA) has remain a topical public health challenge. This study hypothesised that the continuous conspicuous omission of boys/men in the interventions to combat this menace could be a long-life impediment to the realisation of sustainable health for girls and women in the region. The study adopted a systematic review of extant population-based published studies from Scopus, Google Scholars, PubMed, EMBASE, and AJOL. Literature coverage included the post-United Nations' coordinated International Conference on Population and Development (ICPD), Cairo, 1994, which marked the beginning of a massive campaign for women/girls sexual rights. The obtained qualitative data were appraised and synthesised towards spurring policy recommendations for gender balanced initiatives on the sexual and reproductive health rights in SSA. The study highlighted that unwanted pregnancy occurs only when a boy/man has unprotected sex with a girl/woman without considering her choice or rights. It is considered ironic that the dominant factors are boys and men but many enlightenment initiatives/campaigns are concentrated on girls and women. The study developed a schematic save-a-girl-child framework that illustrated the possible dividends inherent in the training of a boy-child to achieve a safer world for the girls/women. It recommends increase in the exposure of boys and men to sexual education and counselling, which can motivate them to be supporters of family planning, supporters of only wanted pregnancy, wanted fatherhood, marital fidelity, intimate partners' harmonious living rather than violence, and wife or partner empowerment.

Young Single Widow, Dynamics of In-Laws Interference and Coping Mechanisms: Simplicity-Parsimony Approach.

The incidence of short marital duration due to the demise of a husband that often exposes young widows to in-laws' exploitation of the asset of the deceased spouses, without regard for negative health consequences and potential vulnerability to poverty has not been exhaustively investigated, especially in sub-Saharan Africa where 16% of adult women are widows. The study examined the coping mechanisms among the young widow (aged ≤ 40) who have experienced short conjugal relationships (≤5 years) and burdensome from in-laws. The research design followed a qualitative approach with the aid of semi-structured in-depth interviews among 13 young widows selected through snowballing and informant-led approaches in the purposively selected communities. Data collected were analysed using descriptive statistics and a thematic approach. The findings, among others, shows the median age of young widow as 29 years. All participants, except one, have faced exploitation from their in-laws over their husbands' assets. All the participants desired to re-marry in order to: have a father figure for their children, have their own children or have more children. There is an absence of government support, but a few have received support from religious organisations. The author proposed attitudinal-change campaigns targeting the in-laws through accessible media and legislature that could challenge the exploitation of widows and unhealthy widowhood rites.

Exposure to Sex Education and Its Effects on Adolescent Sexual Behavior in Nigeria.

Sexual behavior during adolescence fundamentally steers the future life of both girls and boys, and it should be guided with appropriate education, especially as it also represents a key factor to be considered in attainment of sustainable developmental goals. The study assessed the effect of exposure to sex education on adolescents' sexual behavior. The primary and cross-sectional survey data used for this study were analyzed using basic descriptive statistics and binary logistic regression analytical technique. The results, among others, highlighted that the most common sources of first sex education among the respondents are school (54.6%), family (21.6%), social media (9.5%), and others like television (7.6%) and books or magazines (4.9%). Frequency of discussion on sexual matters is positively associated with the use of protection such as condom (ß = 0.261; p ≤ 0.01). The study gave support to the increasing pursuit of sexuality education. However, since adolescents' needs could vary by demographics, streamlining sex education need by age and sex characteristics could enhance its effectiveness.

COVID-19, mobility restriction, and sexual behavior among a cohort of people of reproductive age: Nigeria.

Background: One of the non-pharmaceutical strategies adopted by various governments to control the spread of COVID-19 is mobility restriction (MR), popularly known as a lockdown. Evidence shows that MR has some unintended consequences, such as increased cases of domestic violence, rape, pornography, sex chats, incest, and other unhealthy sexual behaviors (SBs). Methods: The study examined the influence of MR on SB in Owerri via a cross-sectional quantitative approach. A total of 425 interviewees were randomly chosen among people of a reproductive age. Data were analyzed using univariate, bivariate, and multivariate levels of analysis. Results: A significant relationship exists between selected socio-demographic characteristics, such as age and marital status, and the ability of people to cope with sexual abstinence. Results from the logistic regression analysis further illustrated this observation as during MR people were twice as likely to engage in prolific sex chats that could spur other harmful SBs. Conclusion: It is recommended that people should be allowed to determine whether they would like to stay with their partners in subsequent lockdowns, or otherwise, to prevent some of the unpleasant SBs recorded.

Health belief model and behavioural practice of urban poor towards COVID-19 in Nigeria.

Poor adherence to promoting health behaviours is a significant challenge for prevention and management of infectious respiratory diseases. Non-pharmaceutical Interventions (NPIs) remain a proven behavioural practice for reducing the spread of the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) currently ravaging the world. Studies on Covid-19 have primarily focused on epidemiology, virology, and potential drug treatments to the neglect of behavioural practice of low-income settings. This study examines the extent health belief model predicts the behavior of 405 urban poor residents of Ogun State, which recorded the first index case in Nigeria, towards adoption Covid-19 NPIs. A cross-sectional study was conducted to find out the relationship between study participant characteristics, HBM constructs and unhealthy behavior. Study constructs were assessed on a four point Likert scale and were mean aggregated such that higher scores indicated stronger feelings about a construct. Findings shows that urban poor in the age group 30-40 years were more likely to feel susceptible to contracting Covid-19 (mean score: 2.59 and std. dev. 0.54), they also had a higher perception of the benefit of Covid-19 preventive behaviours than participants in other age groups (mean score: 2.95 and std. dev. 0.71). Also, the most prevalent unhealthy behaviour amongst urban poor residents was the indiscriminate use of facemasks as shown by almost half (47.6%) of participants who agreed that they use facemasks all the time even when alone. The study concludes that though urban poor residents feel threatened by Covid-19, nexus of factors such as low financial earnings, inadequate knowledge, and limited access to basic medical needs hamper the effective adoption of NPIs.

Influence of socio-economic factors on prevalence of teenage pregnancy in Nigeria.

The study utilized the theory of fertility as initiated by Davis and Blakes (1956) and developed by Bongaarts in 1978 to underscore why teenage fertility has remained high in Nigeria. This study investigates women socio-economic factors influencing pregnancy in Nigeria. A total sample of 8448 female teenagers with pregnancy experiences were extracted from the 2018 Nigeria Demographic and Health Survey (NDHS). The study revealed that 19% of young girls with 15-19 years have experienced teenage pregnancy in Nigeria. More importantly, the socio-economic factors with significant influence on teenage pregnancy are: respondents with age 18-19 years (33.2 percent), rural (27.2 percent), Islamic religion (25.2 percent), North-west (28.5 percent), poorest (32 percent), no educational (43.7 percent), married/living with partners (73.9 percent), employed (21.5 percent), visited any health facility in the last 12 months (42 percent) and those who were informed about family planning at a health facility (84.3 per cent) . There is need for sound education for females in Nigeria that will equip girls and women with adequate knowledge needed to make informed decisions on matters relating to sexual and reproductive health, hence resulting in the actualization of the SDG 5.

Treatment pathways of Alzheimer in Nigeria.

Alzheimer poses lots of challenges in Low and Middle Income Countries, especially in Nigeria. Globally, the causes of Alzheimer are poorly understood. Cultural factors affect the preference of mental health treatment for treating people living with Alzheimer's disease (PLWA However, Alzheimer's and its gender differentials have been given little consideration in particular. Twenty-four in-depth study was conducted with caregivers and family members/relatives of people living with Alzheimer's (PLWA) residing in the study area. 52.2 percent of respondents were female out of the total while 45.8 percent were male. For male respondents, 40.4%; 49.4 %; 49.2%; 35 % and 28.3% indicated spiritual preference of mental health counseling; traditional; medical practitioner; both traditional and spiritual and psychiatrist respectively. On the other hand, 59.6%; 50.6%; 50.8%; 65% and 70.7% of female respondents indicated spiritual; traditional; medical practitioner; both traditional and spiritual and psychiatrist respectively. This research found that gender disparities primarily affected the mental health intervention care pathways. The availability of mental health resources to support adult mental health were key factors which could influence mental health status.

Nigeria and Italy Divergences in Coronavirus Experience: Impact of Population Density.

BACKGROUND: The reports and information on coronavirus are not conspicuously emphasising the possible impact of population density on the explanation of difference in rapid spread and fatality due to the disease and not much has been done on bicountry comparisons. OBJECTIVE: The study examined the impact of population density on the spread of COVID-19 pandemic in two sociodemographic divergent countries. METHODS: The study conducted a scoping review of published and unpublished articles including blogs on incidences and fatalities of COVID-19. The analysis followed qualitative description and quantitative presentation of the findings using only frequency distribution, percentages, and graphs. RESULTS: The two countries shared similar experience of "importation" of COVID-19, but while different states ordered partial lockdown in Nigeria, it was an immediate total lockdown in Italy. The physician/patient ratio is high in Italy (1 : 328) but low in Nigeria (1 : 2500), while population density is 221 in Nigeria and 206 in Italy. Daily change in incidence rate reduced to below 20% after 51 and 30 days of COVID-19 first incidence in Italy and Nigeria, respectively. Fatality rate has plummeted to below 10% after the 66th day in Italy but has not been stabilised in Nigeria. CONCLUSION: The authors upheld both governments' recommending measures that tilted towards personal hand-hygienic practices and social distancing. Authors suggested that if Italy with its high physician/patient ratio and lower population density compared to Nigeria could suffer high fatality from COVID-19 pandemic under four weeks, then Nigeria with its low physician/patient ratio and higher population density should prepare to face harder time if the pandemic persists.

HIV voluntary counselling and testing and behaviour changes among youths in Nigeria.

Voluntary counselling and testing (VCT) for HIV has been promoted as a strategy to prevent HIV pandemics by changing sexual behaviour. Despite the provision of VCT in countries with generalized or high-burden epidemics, including Nigeria, the extent of its influence on behavioural change remains a conjecture. The main objective of this study was to examine the influence of HIV VCT on sexual behaviour changes among youths in Nigeria. The study utilized 2013 Nigeria Demographic and Health Survey (NDHS) data. Data were analysed from a nationally representative sample drawn from 8046 females and 6031 males aged 15-24 giving a total sample of 14,077 never-married youths. Descriptive and analytical analyses were carried out, including multivariate logistic regression. The study found a low uptake of HIV VCT and regional variation in behavioural changes between female and male youths. Voluntary HIV counselling and testing was found to be a protective factor for condom use at last sex for female youths, but significantly reduced the likelihood of primary sexual abstinence for both females and males, as well as having a single sexual partner for female youths. After controlling HIV VCT with other variables, certain socioeconomic factors were found to be significantly associated with behavioural changes. Thus, the attitudes of most Nigerian youths towards voluntary HIV counselling and testing needs to be improved through socioeconomic factors for healthy sexual activity. To achieve this, government and non-governmental organizations, as well as religious leaders and policymakers, should engage in appropriate and long-term activities directed at the sexual health needs of never-married youths, through voluntary HIV counselling and testing, to encourage them to change their sexual behaviour.

Awareness of Breast and Cervical Cancer among Women in the Informal Sector in Nigeria.

BACKGROUND: There are no general consensuses on why the lifetime risk of dying from breast and cervical cancer in African is several times higher than that of developed countries. However, a notable window of opportunity for prevention and treatment are often wasted where there are little or no awareness and low level of screening. AIM: To specifically highlight the awareness, knowledge and determinants of participation in the screening exercise for possible prevention or control of the diseases. To also provide insights on the development of contextual and relevant timely detection for effective early interventions. METHODS: A cross-sectional study was conducted in southern and northern geopolitical zones of Nigeria. The respondents, which consisted of 1,023 women aged 15-49 years, completed a 116-item questionnaire assessing the correlation between cancer awareness and participation in screening. Nineteen, In-depth interviews were also conducted for this study. The outcome measured included awareness of breast and cervical cancer, how it can be prevented or detected, and the availability and actual participation in screening exercises. RESULTS: While women are familiar with breast cancer, little is known about cervical cancer, and the awareness of the former is not correlated with participation in screening. THE LACK OF ENTHUSIASM TO SEEK SCREENING EXERCISE IS ROOTED IN THREE KEY FACTORS: lack of specific information, belief, economic and inadequate screening facilities. CONCLUSION: The study thus recommends that policies and programs aimed at the breast and cervical cancers awareness and early intervention should address the underlying problems.

Variations in Family Attitudes towards Coping with People Living with Mental Illness.

BACKGROUND: The major challenge faced in Nigeria regarding the care of people living with mental illness are a stigma, caregiver burden and financial aid. This has led to high premature deaths and has also hindered the attainment of Sustainable Development Goal 3 target 4. In an attempt to find lasting solutions to increased mortality caused by mental illness, it is important to evaluate family attitudes towards people living with mental illness. AIM: To examine variations in family attitudes towards coping with people living with mental illness in Nigeria. SUBJECTS AND METHODS: Thirty In-Depth Interview (IDI) were conducted among caregivers of people living with mental illness (those presently receiving treatment and those recovering). During all the interview sessions, field notes were taken. Responses from interviewees were transcribed and analysed with the aid of 'systematic-content analysis. RESULTS: It found out that family members of people living with mental illness or caregivers usually suffer from stress and stigma, which affects adherence to treatment. CONCLUSION: Caregivers must have sufficient knowledge and support to assume the responsibilities of caring for the mentally ill, leading to recurrence. The caregiver remains in contact with professional healthcare workers and helps the mentally ill with decision-making and matters affecting their daily life.

Asymptomatic malaria infections and Pfmdr1 mutations in an endemic area of Nigeria.

BACKGROUND: Malaria eradication globally is yet to be achieved and transmission is sustained in many endemic countries. Plasmodium falciparum continues to develop resistance to currently available anti-malarial drugs, posing great problems for malaria elimination. This study evaluates the frequencies of asymptomatic infection and multidrug resistance-1 (mdr-1) gene mutations in parasite isolates, which form the basis for understanding persistently high incidence in South West, Nigeria. METHODS: A total of 535 individuals aged from 6 months were screened during the epidemiological survey evaluating asymptomatic transmission. Parasite prevalence was determined by histidine-rich protein II rapid detection kit (RDT) in healthy individuals. Plasmodium falciparum mdr-1 gene mutations were detected by polymerase chain reaction (PCR) followed by restriction enzyme digest and electrophoresis to determine polymorphism in parasite isolates. Sequencing was done to confirm polymorphism. Proportions were compared using Chi-square test at p value < 0.05. RESULTS: Malaria parasites were detected by RDT in 204 (38.1%) individuals. Asymptomatic infection was detected in 117 (57.3%) and symptomatic malaria confirmed in 87 individuals (42.6%). Overall, individuals with detectable malaria by RDT was significantly higher in individuals with symptoms, 87 of 197 (44.2%), than asymptomatic persons; 117 of 338 (34.6%), p = 0.02. In a sub-set of 75 isolates, 18(24%) and 14 (18.6%) individuals had Pfmdr1 86Y and 1246Y mutations. CONCLUSIONS: There is still high malaria transmission rate in Nigeria with higher incidence of asymptomatic infections. These parasites harbour mutations on Pfmdr1 which contribute to artemisinin partner drug resistance; surveillance strategies to reduce the spread of drug resistance in endemic areas are needed to eliminate the reservoir of malaria parasites that can mitigate the eradication of malaria in Nigeria.

Knowledge and Attitudes about Breast Cancer among Women: A Wake-Up Call in Nigeria.

BACKGROUND: Preventable deaths resulting from the scourge of breast cancer has become alarming and worrisome in many societies in developing countries, including Nigeria. Of much concern is the fact that breast cancer has continued to claim the precious lives of young, middle-aged, old, educated and non-educated women irrespective of their religion, socio-economic background and socio-demographic characteristics. AIM: This study attempts to ascertain the knowledge and attitudes of women to breast cancer in Ogun State, Nigeria. METHODS: The study adopts both primary and secondary data sources to examine the level of knowledge and attitude of women towards breast cancer with the view of suggesting probable solutions and recommendations for policy. RESULTS: The result indicates that the awareness about breast cancer is overwhelming but only few women know about mammography; women in older age are 0.193 times less likely to attend breast cancer screening (p=0.000). Older women with secondary education that are either self-employed outside the home or full-time housewives are unfavourably disposed to breast cancer screening. CONCLUSION: The authors recommend that concerned stakeholders in the health sector and policy decision makers should intensify action on cancer programmes and campaigns that could target older women especially housewives and women in middle level education.

Dataset on perception of public college students on underage drinking in Nigeria.

Alcohol is the most widely used substance of abuse among youths in Nigeria. Underage drinking poses a serious public health problem in most colleges and despite the health and safety risk, consumption of alcohol is rising. Having recourse to the public health objective on alcohol by the World Health organization, which is to reduce the health burden caused by the harmful use of alcohol, thereby saving live and reducing injuries, this data article explored the nature of alcohol use among college students, binge drinking and the consequences of alcohol consumption. Secondary school students are in a transition developmentally and this comes with its debilitating effects such as risky alcohol use which affects their health and educational attainment [1], [2]. This data article consists of data obtained from 809 (ages 14-20 years) participants from selected schools in Ota, near Lagos State, Nigeria. For data collection, the youth questionnaire on underage drinking was employed. This data article presents information on participants' alcohol demographics. Analyses of the data can provide insights into heavy episodic drinking (HED), ever drinkers, prevalence of alcohol consumption, strategies to reducing alcohol use, reasons for underage drinking and effects of alcohol consumption. The data will be useful for public health interventions.

Moderating Role of Demographic Characteristics in Breast Cancer Awareness and the Behavioural Disposition of Women in Ogun State, Nigeria.

BACKGROUND: Breast cancer incidence is fast increasing, posing a significant threat to the health of women of all races globally. In Nigeria, breast cancer causes the most cancer-related deaths among women each year as a result of inadequate awareness. AIM: This study is aimed at examining the moderating role of demographic characteristics in facilitating breast cancer awareness among women, and how it relates to their behavioural disposition to the disease. METHODS: The study adopted the descriptive (survey) and cross-sectional research designs to elicit information from women of adult age selected across five Local Government Areas in Ogun state. The data, collected through questionnaire were analysed through the use of a variance-based SEM Partial Least Square (PLS). RESULTS: The result shows that demographic characteristics (age and education) has a significant positive effect and jointly explain 74.9% of the variance in the breast cancer awareness and behavioural disposition among women in the study area. The findings revealed that a significant number of women with breast cancer had not acquired useful knowledge that could potentially be used to diagnose, prevent, and manage the disease. Unfortunately, the practice of Breast Self-Examination is grossly low among Nigerian women, as a consequence, only 20-30% of the women in study areas, including professionals, are aware of the benefits of BSE and only a smaller percentage practice BSE. CONCLUSION: There is, therefore, a need to educate women on the benefits of this simple life-saving procedure through the consistent use of media platforms.

Dataset on analysis of quality of health and social insurance subscription in different socio-economic class of workers in selected areas in southwest Nigeria.

National social health insurance scheme aims to improve the health of citizens and provide equal access to health care across different income classes. This empirical datasets describes quality of health, insurance subscription, awareness, health care coverage and benefits in different socio-economic class of workers in Ota and Lagos, Nigeria. The perception of individual׳s state of health and level of satisfaction of accessed health care are reported and opinions on ways to meet the health needs of workers in a developing country such as Nigeria.

Trends, Determinants and Health Risks of Adolescent Fatherhood in Sub-Saharan Africa.

BACKGROUND: This study examined the trends, determinants and health risks of adolescent fatherhood in three selected African countries where adolescent-girl pregnancy/motherhood are decried but with permissive male sexual latitude. METHODS: Adolescent male data were extracted from the malerecode datasets of Demographic Health Survey (2000-2014) for Nigeria, Ethiopia and Zambia. The surveys were grouped into 3-Waves: (2000-2004); (2005-2008) and (2011-2014). The study employed descriptive and binary logistics that tested the log-odds of adolescent fatherhood with respect to selected sexual behaviour indices, and individual and shared demographic variables. RESULTS: The results revealed that the number of lifetime-sexual-partners among the boys is ≥2. The likelihood of adolescent fatherhood is positively associated with increasing age at first cohabitation and multiple sexual partnerships (≥2) having OR=1.673 and OR=1.769 in 2005/2008 and 2011/2014 respectively. Adolescents who had attained tertiary education, and engaged in professional and skilled jobs were 0.313, 0.213 and 0.403 times (respectively) less likely to have ever-fathered a child. The positive association between rural place of residence and adolescent fatherhood in the past shifted to urban residents in 2011/2014. CONCLUSION: The study concludes that early sexual activities and cohabitation are common among male adolescents among the countries of study. The authors recommend discouragement of boy-girl cohabitation, increasing access to higher education and job opportunities in order to stem boy-fatherhood incidence in the study locations and, by extension, other countries in sub-Saharan Africa.

Improving postnatal checkups for mothers in West Africa: A multilevel analysis.

This study examined multilevel factors related to postnatal checkups for mothers in selected West African countries. The study analyzed data from Demographic and Health Surveys (DHS) for five West African countries: Sierra Leone (2013), Cote d'Ivoire (2012), Guinea (2012), Niger (2012), and Liberia (2013). The weighted sample sizes were 2125 (Cote d'Ivoire), 2908 (Guinea), 1905 (Liberia), 5660 (Niger), and 3754 (Sierra Leone). The outcome variable was maternal postnatal checkups. The explanatory variables were community and individual/household characteristics. With the use of Stata 12, the chi-square statistic and multilevel mixed-effects logistic regression were applied. More than two-thirds of respondents in Guinea and Niger did not receive a postnatal checkup after their last birth, while in Cote d'Ivoire, Liberia, and Sierra Leone, more than half of respondents received a postnatal checkup after their last childbirth. Community characteristics accounted for the following variations in postnatal checkups: 33.9% (Cote d'Ivoire), 37.2% (Guinea), 27.0% (Liberia), 33.5% (Niger), and 37.2% (Sierra Leone). Community factors thus had important relations to use of postnatal care in West Africa. Interventions targeting more community variables, particularly community education and poverty, may further improve postnatal care in West Africa.