Clinical evaluation of a new cosmetic cream containing PEPHA®-TIGHT on the skin of childbearing women.

The purpose of this study is to evaluate the efficacy of daily application of a new cosmetic cream on the skin of childbearing women. Fifty-two childbearing women were evaluated and each subject was initially (T0) prepared using an hydration and sebometry test. A quantity of 50 ml of cosmetic cream was applied for 1 month on each patient. At the end of the month (T1), the tests were repeated. At the end of the study, all enrolled women showed an improvement of facial skin hydration and sebum normalization and reduction of skin aging. The present study shows that the cosmetic preparations containing PEPHA®-TIGHT and other moisturizing agents are able to improve skin hydration and reduce skin aging, according to several published clinical trials. The absence of a control group and the short observation time limits this study.

Spontaneous retrospective clinical evaluation of a new phytoestrogen-based cosmetic gel cream on postmenopausal women's skin.

The purpose of this study is to evaluate the efficacy of daily application of a new phytoestrogen-based cosmetic gel cream on postmenopausal women's skin. Sixty postmenopausal women were evaluated. Each subject was initially (T0) submitted to a hydration and sebometry test. A quantity of 50 ml of phytoestrogen-containing gel cream was given for one month to each patient. At the end of the month (T1), the tests were repeated. At the end of the study, 85% of the women showed an improvement of facial skin hydration. All the women who took part in the study had facial skin sebum normalization. The present study confirms that cosmetic preparations containing phytoestrogen are able to reduce skin aging, according to several published clinical trials. Nevertheless, the absence of a control group and the short observation time limited this study.

Chronic inflammation therapy combined with low dose cytokines in the treatment of chronic ulcers of lower limbs.

Prevalence of chronic venous leg ulcers has increased from 55% to 75% in 10 years. We treat chronic vascular lesions according to a cyclic multiphase method that follows the instrumental and differential etiologic diagnosis of ulcers of the lower limbs. The AIMED (Anti Inflammatory Regenerative Medicine) operating model follows the diagnostic phase and is structured in 5 interconnected phases. Mare evaluation, pH control, biofilm removal and prevention and infections are approached according to the International Guidelines. Low-dose cytokine therapy to contrast the inflammatory process are administrated to the patients. Chronic skin lesions of these patients, treated according to the AIMED protocol, have been evaluated twice a week. The clinical evaluation parameters evaluated by us were: reduction of pain at 15 and 30 days, reduction of 50% of the injury at 30 days, characteristics of perilesional skin (edema, erythema) and global profile of the patient. The so-called Low Dose Cytokines therapy is changing the previous therapeutic algorithms thanks to a safe and effective systemic cytokines-receptors interactive physiological process.

[In vivo effects of conjugated estrogens on the insulin receptor and on glucose binding in isolated adipocytes of male rats]. / Action in vivo d'oestrogènes conjugués sur le récepteur de l'insuline et sur la fixation du glucose dans les adipocytes isolés du rat mâle.

Studies have been carried out with labeled substrates on isolated adipocytes of male rats injected with sulpho-conjugated estrogens. Three days treatment did not affect insulin receptor concentration or affinity in the cells. Conversely glucose uptake is reduced in the absence of insulin, or by reduced responsiveness in the presence of it. After ten days treatment, insulin binding impaired on account of reduced receptor concentration, whereas glucose uptake was normal in the absence of insulin, increased at low and decreased at high insulin concentration, on account of both decreased responsiveness and increased sensibility to insulin. Thus it is suggested that estrogens acts on glucose uptake prior to act on the insulin receptor in the adipocytes.