A descriptive study of vitamin D and other nutritional factors in breast cancer patients in Saudi Arabia.

OBJECTIVES: To assess the role of serum vitamin D and other nutritional factors in women with breast cancer in Saudi. METHODS: A total of 500 women (250 patients with breast cancer and 250 controls) aged 30-60 years were recruited from King Saud Medical City and King Fahad Medical City, Riyadh, Saudi Arabia,  between May 2015 and June 2016. In this cross-sectional study, blood pressure, plasma concentrations of vitamin D, and calcium levels were evaluated. A 3-day dietary record was used to assess dietary intake. RESULTS: The mean body mass index was  31.2±7.0  kg/m2   for the breast cancer group and 30.7±7.6 kg/m2 for the control group. More than 80% of the participants had insufficient vitamin D levels (less than 75.0 nmol/L). The mean cholesterol intake was significantly (p=0.001) lower in the control group (233.1±75.1 mg) than in the breast cancer group (257.2±84.8 mg). Breast density was found to be significantly associated with vitamin D deficiency-symptoms. Severe paresthesia was also significantly associated with breast cancer. The incidence of other vitamin D deficiency-symptoms was significantly higher in the control group. CONCLUSION: Due to prevalence of vitamin D deficiency in Saudi Arabia, it is difficult to determine the relationship to breast cancer. The incidence of it is associated with old age and high cholesterol intake, and paresthesia may be a symptom of breast cancer.

Erectile dysfunction in hemodialysis patients.

Erectile dysfunction (ED) is a common problem seen among patients on hemodialysis (HD), but it is still a taboo subject in our country. The attention given to this sexual problem remained low, and the prevalence of ED among these patients has not been well characterized. We carried out this study in order to determine the prevalence and severity of ED in HD patients. We conducted a descriptive cross-sectional study in our HD unit in March 2013. ED was evaluated using the International Index Erection Function. Thirty patients with a mean age of 49.1 years were eligible for this study. The main causes of chronic kidney disease were hypertension (62.5%) and diabetes (41.6%). The prevalence of ED was 80%, including 33.3% severe ED. Plasma levels of gonadotropins: luteinizing hormone (LH), follicule-stimulating hormone were in the standards except for one patient who had an elevated level of LH. Prolactin was elevated in four cases. ED was present in 8.4% of patients before the discovery of renal failure and in 91.6% of patients at the beginning of dialysis. For 19 patients (79.1%), the ED had increased during the dialysis sessions. A significant number of our HD patients presented with ED of varying degrees. Nephrologists should pay attention to the problem of ED in order to improve the quality of their life.

Post kidney transplantation Kaposi's sarcoma: the experience of a Mediterranean North African center.

BACKGROUND: The aim of this study was to determine the overall and specific incidences of Kaposi's sarcoma (KS) in a cohort of 568 kidney transplant recipients (KTR) in a single North African Mediterranean center. PATIENTS AND METHODS: The records of 568 patients, who underwent kidney transplantation (KT) between June 1986 and December 2013, were retrospectively reviewed. Incidence was calculated by dividing the number of the different events by the total duration of follow-up. Survival rates and cumulated frequencies of KS were calculated according to the actuarial method. RESULTS: Twelve patients developed KS corresponding to an overall prevalence of 2.1% and an annual incidence of 0.27% patient-years. Median time to diagnosis of KS was 23.3 months. Eleven patients presented with skin lesions; three had oral localizations and one had conjunctival involvement. Asymptomatic gastric localization was observed in one patient. Therapeutic management, consisting in reduction of immunosuppression in all cases and their conversion to sirolimus in four patients, resulted in complete regression of KS in seven patients. Graft loss was observed in three cases and four patients died of unrelated- KS causes. CONCLUSION: KS is the most post KT malignancy observed in our country and is characterized by a predominance of limited superficial forms.