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1.
Can Vet J ; 64(12): 1133-1142, 2023 Dec.
Artículo en Inglés | MEDLINE | ID: mdl-38046420

RESUMEN

Background and objective: For several years, there has been growing concern over the public and animal health impacts of dog importation, with many Canadian veterinarians reporting increasing diagnoses of exotic pests and pathogens. This study is the first to estimate the number of dogs imported into Canada and describe spatial and temporal trends. Animal and procedure: Commercial and a subset of personal dog importation records, obtained from the Canada Border Services Agency, were used to estimate the total number of dogs imported into Canada from 2013 to 2019. Results: The number of dogs imported annually increased by > 400% over the study period, with > 37 000 dogs imported in 2019. The majority of dogs (72%) were imported from the United States and Eastern Europe, and 23% originated in a country considered high-risk for canine rabies. Conclusion: Dog importation into Canada has increased substantially over time. Moving forward, education and improved tracking will be essential.


Estimation des tendances spatiales et temporelles de l'importation de chiens au Canada de 2013 à 2019. Contexte et objectif: Depuis plusieurs années, les impacts de l'importation de chiens sur la santé publique et animale suscitent de plus en plus d'inquiétudes, de nombreux vétérinaires canadiens signalant une augmentation des diagnostics de vermines et d'agents pathogènes exotiques. Cette étude est la première à estimer le nombre de chiens importés au Canada et à décrire les tendances spatiales et temporelles. Animal et procédure: Des dossiers d'importation de chiens commerciaux et personnels, obtenus auprès de l'Agence des services frontaliers du Canada, ont été utilisés pour estimer le nombre total de chiens importés au Canada de 2013 à 2019. Résultats: Le nombre de chiens importés chaque année a augmenté de > 400 % au cours de la période d'étude, avec > 37 000 chiens importés en 2019. La majorité des chiens (72 %) ont été importés des États-Unis et d'Europe de l'Est, et 23 % sont originaires d'un pays considéré comme à haut risque de rage canine. Conclusion: L'importation de chiens au Canada a considérablement augmenté au fil du temps. À l'avenir, l'éducation et un meilleur suivi seront essentiels.(Traduit par Dr Serge Messier).


Asunto(s)
Enfermedades de los Perros , Rabia , Animales , Estados Unidos , Perros , Enfermedades de los Perros/epidemiología , Enfermedades de los Perros/diagnóstico , Canadá/epidemiología , Rabia/epidemiología , Rabia/prevención & control , Rabia/veterinaria
2.
CMAJ ; 195(31): E1030-E1037, 2023 08 14.
Artículo en Inglés | MEDLINE | ID: mdl-37580072

RESUMEN

BACKGROUND: During the first year of the COVID-19 pandemic, the proportion of reported cases of COVID-19 among Canadians was under 6%. Although high vaccine coverage was achieved in Canada by fall 2021, the Omicron variant caused unprecedented numbers of infections, overwhelming testing capacity and making it difficult to quantify the trajectory of population immunity. METHODS: Using a time-series approach and data from more than 900 000 samples collected by 7 research studies collaborating with the COVID-19 Immunity Task Force (CITF), we estimated trends in SARS-CoV-2 seroprevalence owing to infection and vaccination for the Canadian population over 3 intervals: prevaccination (March to November 2020), vaccine roll-out (December 2020 to November 2021), and the arrival of the Omicron variant (December 2021 to March 2023). We also estimated seroprevalence by geographical region and age. RESULTS: By November 2021, 9.0% (95% credible interval [CrI] 7.3%-11%) of people in Canada had humoral immunity to SARS-CoV-2 from an infection. Seroprevalence increased rapidly after the arrival of the Omicron variant - by Mar. 15, 2023, 76% (95% CrI 74%-79%) of the population had detectable antibodies from infections. The rapid rise in infection-induced antibodies occurred across Canada and was most pronounced in younger age groups and in the Western provinces: Manitoba, Saskatchewan, Alberta and British Columbia. INTERPRETATION: Data up to March 2023 indicate that most people in Canada had acquired antibodies against SARS-CoV-2 through natural infection and vaccination. However, given variations in population seropositivity by age and geography, the potential for waning antibody levels, and new variants that may escape immunity, public health policy and clinical decisions should be tailored to local patterns of population immunity.


Asunto(s)
COVID-19 , SARS-CoV-2 , Humanos , COVID-19/epidemiología , Pandemias , Estudios Seroepidemiológicos , Alberta , Anticuerpos Antivirales
3.
Can Commun Dis Rep ; 49(1): 1-4, 2023 Jan 05.
Artículo en Inglés | MEDLINE | ID: mdl-36815867

RESUMEN

Importation of rabies-infected dogs results in significant and costly public and animal health risks. In January 2022, a dog in Ontario, Canada, which was imported from Iran in June 2021, developed rabies, leading to an extensive public health investigation and administration of rabies post-exposure prophylaxis to 37 individuals. The dog was infected with a rabies virus variant known to circulate in Iran. This is the second reported case of a rabies-infected dog imported into Canada in 2021 from a high-risk country for canine mediated rabies. This case emphasizes the need for public education regarding the risks associated with importing dogs from high-risk countries for canine-mediated rabies and the benefits of establishing a public health team specializing in rabies exposure investigations.

4.
BMC Complement Med Ther ; 22(1): 118, 2022 Apr 28.
Artículo en Inglés | MEDLINE | ID: mdl-35484545

RESUMEN

BACKGROUND: Although the vast majority of cancer patients use natural health products (NHPs), 59% of oncology healthcare providers (HCP) report not receiving any education on NHPs. KNOWintegrativeoncology.org (KNOW) is a web-based educational platform that provides up-to-date evidence on NHPs used in cancer care with a user-friendly interface. KNOW is a database of human studies systematically gathered from MEDLINE and EMBASE. We surveyed HCPs before and after accessing KNOW to identify their information needs regarding NHPs in cancer care, their preferred way to receive information, barriers they face accessing NHP information, and to obtain feedback on the website. METHODS: Recruitment was done through Beaumont Health Systems, the Society for Integrative Oncology, and the Andrew Weil Centre for Integrative Medicine, University of Arizona. HCPs who consented completed an initial survey and then a follow-up survey after being given access to KNOW for 4-6 weeks. Participants were required to access KNOW at least three times before completion of the follow-up survey. RESULTS: A total of 65 participants completed the initial survey, with 60% (n = 39) from the conventional medical community, 33% (n = 21) from the integrative medicine community, and 7% (n = 5) from the research community. The majority of participants (82%; n = 53) preferred educational websites to email updates, podcasts/webinars, in-house experts, PubMed searches and smartphone apps. The most common barriers identified to accessing information on NHPs were time, accessibility at point-of-care, and credibility of sources. A high number of participants were lost to follow up, with 18 participants demographically representative of the initial sample of 65 completing the follow-up survey. Half (n = 9) of participants stated accessing the KNOW website changed their clinical practice. Close to 90% (n = 16) reported they would recommend KNOW to a colleague. CONCLUSION: Oncology HCPs reported preferring to use, and already relying on, numerous web-based educational platforms to gather information on NHPs, with time, accessibility, and credibility being common barriers to obtaining information. Our study findings highlight the promise of the KNOW web-based educational platform in reducing barriers to accessing up-to-date information on NHPs in busy cancer care settings.


Asunto(s)
Productos Biológicos , Neoplasias , Escolaridad , Personal de Salud , Humanos , Encuestas y Cuestionarios
5.
Antibiotics (Basel) ; 11(2)2022 Feb 10.
Artículo en Inglés | MEDLINE | ID: mdl-35203828

RESUMEN

Surveillance of antimicrobial use (AMU) and antimicrobial resistance (AMR) is a core component of the 2017 Pan-Canadian Framework for Action. There are existing AMU and AMR surveillance systems in Canada, but some stakeholders are interested in developing their own AMU monitoring/surveillance systems. It was recognized that the establishment of core (minimum) AMU data elements, as is necessary for policy or intervention development, would inform the development of practical and sustainable AMU surveillance capacity across food animal sectors in Canada. The Canadian Animal Health Surveillance System (CAHSS) AMU Network was established as a multisectoral working group to explore the possibility of harmonizing data inputs and outputs. There was a consensus that a minimum AMU dataset for AMU surveillance (MDS-AMU-surv) should be developed to guide interested parties in initiating AMU data collection. This multisectoral collaboration is an example of how consultative consensus building across relevant sectors can contribute to the development of harmonized approaches to AMU data collection and reporting and ultimately improve AMU stewardship. The MDS-AMU-surv could be used as a starting point for the progressive development or strengthening of AMU surveillance programs, and the collaborative work could serve as a model for addressing AMR and other shared threats at the human-animal-environment interface.

6.
Can Commun Dis Rep ; 48(6): 238-242, 2022 Jun 09.
Artículo en Inglés | MEDLINE | ID: mdl-37333573

RESUMEN

In July 2021, a dog was imported into Canada from Iran and subsequently developed clinical signs of rabies within 11 days of arrival. Following laboratory confirmation of the diagnosis of rabies, local, provincial and federal inter-agency collaboration was required to complete contact tracing to identify all persons and domestic animals that may have been exposed to the rabid dog during the potential virus shedding period. This case highlights the risks of importing animals from known canine rabies-endemic areas, identifies gaps in current dog importation policies that pose potential risk to human and animal health and prompts ongoing vigilance for this deadly disease among human and animal health partners, as well as members of the public who adopt imported dogs.

7.
Can Commun Dis Rep ; 48(9): 415-419, 2022 Sep 01.
Artículo en Inglés | MEDLINE | ID: mdl-38106646

RESUMEN

Background: The coronavirus disease 2019 (COVID-19) pandemic has caused substantial disruption to in-person learning, often interfering with the social and educational experience of children and youth across North America, and frequently impacting the greater community by limiting the ability of parents and caregivers to work outside the home. Real-world evidence related to the risk of COVID-19 transmission in school settings can help inform decisions around initiating, continuing, or suspending in-person learning. Methods: We analyzed routinely collected case-based surveillance data from Saskatchewan's electronic integrated public health system, Panorama, from the 2020-2021 school year, spanning various phases of the pandemic (including the Alpha variant wave), to better understand the risk of in-school transmission of COVID-19 in Saskatchewan schools. Results: The majority (over 80%) of school-associated COVID-19 infections were acquired outside the school setting. This finding suggests that the non-pharmaceutical measures in place (including masking, distancing, enhanced hygiene, and cohorting) worked to limit viral spread in schools. Conclusion: Implementation of such control measures may play an essential role in allowing children and youth to safely maintain in-person learning during the pandemic.

8.
Can Commun Dis Rep ; 47(11): 485-490, 2021 Nov 10.
Artículo en Inglés | MEDLINE | ID: mdl-35330955

RESUMEN

Background: An outbreak of the coronavirus disease 2019 (COVID-19) occurred in Saskatchewan from September 12 to October 20, 2020. The index event, attendance at a local gym, seeded six additional clusters/outbreaks in multiple settings. These included a high school, a hospital, three workplaces (A, B and C) and several households. The overall cluster comprised 63 cases, 27 gym members and an additional 36 second, third and fourth generation cases. Methods: All outbreak-related, laboratory-confirmed cases of COVID-19 were included in the analysis. Local public health authorities interviewed all cases and contacts and conducted environmental investigations of the fitness facility. We used descriptive epidemiological methods to understand transmission dynamics of the gym-associated cluster using case investigation, contact investigation and laboratory data, including whole genome sequencing. Results: Sequencing data confirmed the unique lineage of cluster-related cases (n=32 sequenced; severe acute respiratory syndrome coronavirus 2 [SARS-CoV-2] lineage B.1.1.72). In addition to gym attendance, infectious cases attended high school and were involved in other activities. Despite ongoing transmission in the fitness facility, no secondary cases were identified in the high school where four student belonging to the cluster attended class during their infectious period. Conclusion: We describe an outbreak of COVID-19 where the index case(s) attended a fitness facility, and further spread occurred for 38 days despite active-case finding and isolation of positive cases over this period. Due to gym attendance over time, short-term closing and cleaning may not interrupt chains of transmission. Targeted, preventive public health action in fitness facilities may be warranted. Control measures worked to limit in-school acquisition.

9.
Emerg Infect Dis ; 26(12): 3079-3080, 2020 12.
Artículo en Inglés | MEDLINE | ID: mdl-33219799

RESUMEN

We evaluated the prevalence of Brucella canis seropositivity in a convenience sample of dogs from commercial breeding kennels in Ontario, Canada. Overall, 127/1,080 (11.8%) dogs from 23/63 (37%) kennels were seropositive. The prevalence of positive dogs within kennels with >1 positive dog ranged from 3.9% to 100% (median 33%).


Asunto(s)
Brucella canis , Brucelosis , Enfermedades de los Perros , Animales , Brucella canis/genética , Brucelosis/epidemiología , Brucelosis/veterinaria , Enfermedades de los Perros/epidemiología , Perros , Ontario/epidemiología , Prevalencia
10.
Int J Equity Health ; 18(1): 171, 2019 11 10.
Artículo en Inglés | MEDLINE | ID: mdl-31707981

RESUMEN

BACKGROUND: A small proportion of the population consumes the majority of health care resources. High-cost health care users are a heterogeneous group. We aim to segment a provincial population into relevant homogenous sub-groups to provide actionable information on risk factors associated with high-cost health care use within sub-populations. METHODS: The Canadian Institute for Health Information (CIHI) Population Grouping methodology was used to define mutually exclusive and clinically relevant health profile sub-groups. High-cost users (> = 90th percentile of health care spending) were defined within each sub-group. Univariate analyses explored demographic, socio-economic status, health status and health care utilization variables associated with high-cost use. Multivariable logistic regression models were constructed for the costliest health profile groups. RESULTS: From 2015 to 2017, 1,175,147 individuals were identified for study. High-cost users consumed 41% of total health care resources. Average annual health care spending for individuals not high-cost were $642; high-cost users were $16,316. The costliest health profile groups were 'long-term care', 'palliative', 'major acute', 'major chronic', 'major cancer', 'major newborn', 'major mental health' and 'moderate chronic'. Both 'major acute' and 'major cancer' health profile groups were largely explained by measures of health care utilization and multi-morbidity. In the remaining costliest health profile groups modelled, 'major chronic', 'moderate chronic', 'major newborn' and 'other mental health', a measure of socio-economic status, low neighbourhood income, was statistically significantly associated with high-cost use. INTERPRETATION: Model results point to specific, actionable information within clinically meaningful subgroups to reduce high-cost health care use. Health equity, specifically low socio-economic status, was statistically significantly associated with high-cost use in the majority of health profile sub-groups. Population segmentation methods, and more specifically, the CIHI Population Grouping Methodology, provide specificity to high-cost health care use; informing interventions aimed at reducing health care costs and improving population health.


Asunto(s)
Costos de la Atención en Salud/estadística & datos numéricos , Aceptación de la Atención de Salud/estadística & datos numéricos , Adolescente , Adulto , Anciano , Anciano de 80 o más Años , Canadá , Demografía , Femenino , Estado de Salud , Humanos , Masculino , Persona de Mediana Edad , Factores de Riesgo , Factores Socioeconómicos , Adulto Joven
11.
Emerg Infect Dis ; 25(10): 1810-1816, 2019 10.
Artículo en Inglés | MEDLINE | ID: mdl-31538556

RESUMEN

Canine influenza virus (CIV) A(H3N2) was identified in 104 dogs in Ontario, Canada, during December 28, 2017-October 30, 2018, in distinct epidemiologic clusters. High morbidity rates occurred within groups of dogs, and kennels and a veterinary clinic were identified as foci of infection. Death attributable to CIV infection occurred in 2 (2%) of 104 diagnosed cases. A combination of testing of suspected cases, contact tracing and testing, and 28-day isolation of infected dogs was used, and CIV transmission was contained in each outbreak. Dogs recently imported from Asia were implicated as the source of infection. CIV H3N2 spread rapidly within groups in this immunologically naive population; however, containment measures were apparently effective, demonstrating the potential value of prompt diagnosis and implementation of CIV control measures.


Asunto(s)
Enfermedades de los Perros/epidemiología , Subtipo H3N2 del Virus de la Influenza A , Infecciones por Orthomyxoviridae/veterinaria , Animales , Trazado de Contacto/veterinaria , Brotes de Enfermedades/prevención & control , Brotes de Enfermedades/veterinaria , Enfermedades de los Perros/prevención & control , Enfermedades de los Perros/virología , Perros , Ontario/epidemiología , Infecciones por Orthomyxoviridae/epidemiología , Infecciones por Orthomyxoviridae/prevención & control , Infecciones por Orthomyxoviridae/virología
12.
Vet Clin North Am Small Anim Pract ; 49(4): 587-598, 2019 Jul.
Artículo en Inglés | MEDLINE | ID: mdl-30956000

RESUMEN

Canine and feline infectious diseases are constantly changing in frequency and location. Numerous drivers or determinants of these changes are suspected, including emergence of new pathogens; change in virulence and resistance of existing pathogens; change in land use, climate, and weather; travel and trade; habitat destruction and urbanization; change in animal-animal contact networks; host susceptibility; availability and uptake of prevention measures; and change in ability to detect pathogens and track diseases. This article explores each of these proposed drivers and examines examples of feline and canine diseases likely to be influenced by them.


Asunto(s)
Enfermedades de los Gatos/microbiología , Enfermedades Transmisibles/veterinaria , Enfermedades de los Perros/microbiología , Animales , Enfermedades de los Gatos/epidemiología , Gatos , Enfermedades Transmisibles/epidemiología , Enfermedades de los Perros/epidemiología , Perros , Vigilancia de la Población , Factores de Riesgo
13.
Vet Clin North Am Small Anim Pract ; 49(4): 615-627, 2019 Jul.
Artículo en Inglés | MEDLINE | ID: mdl-30956001

RESUMEN

Translocation of dogs inherently poses infectious disease risks when pathogen distributions vary between regions, even within the same country. Concerns include introduction of novel pathogens that can infect dogs, zoonotic pathogens, pathogens that can become established in existing reservoirs or vectors, and vectors that might carry pathogens and/or become established in a new region. This article presents the drivers of canine movement and their relative risks, and provides examples of diseases to show how different pathogen characteristics and transmission pathways can affect the impact of movement of infected dogs.


Asunto(s)
Enfermedades Transmisibles/veterinaria , Enfermedades de los Perros/transmisión , Animales , Enfermedades Transmisibles/transmisión , Perros , Transportes , Zoonosis/transmisión
14.
Glob Adv Health Med ; 7: 2164956118788853, 2018.
Artículo en Inglés | MEDLINE | ID: mdl-30038847

RESUMEN

BACKGROUND: Despite pharmacological and psychosocial support, pediatric blood and marrow transplant (BMT) recipients typically experience heightened levels of somatic and psychological distress while undergoing transplant. Although clinicians have used psychosocial interventions to target distress, there are gaps in the literature concerning music therapy for children recovering from BMT. This is especially the case among younger children and those affected by rare genetic or metabolic disorders. OBJECTIVE: As caregivers are the primary decision makers for minor children, there is a need to understand their preferences and values as this constitutes a component of evidence-informed practice. Therefore, the purpose of this interpretivist investigation was to explore primary caregivers' perspectives and experiences with music therapy for their children during hospitalization for BMT. METHODS: The researchers conducted semistructured phone interviews with 15 primary caregivers of children who had received music therapy services while hospitalized for BMT. Member checking was used to ensure accuracy of the transcripts and experiences, while trustworthiness was used to verify themes. RESULTS: Fifteen caregivers of 14 pediatric BMT recipients were interviewed by phone. The following four themes emerged: (1) music therapy motivated patients to physically engage their bodies despite symptoms; (2) music therapy elevated patients' moods; (3) caregivers benefited from seeing their child engaged in music therapy; and (4) caregivers were appreciative for the opportunity and requested additional music therapy services. CONCLUSIONS: Caregivers perceived music therapy to be a positive and beneficial experience for pediatric patients while hospitalized for BMT. Implications for clinical practice, limitations, and suggestions for future research are provided.

15.
Can J Public Health ; 109(3): 362-368, 2018 06.
Artículo en Inglés | MEDLINE | ID: mdl-29981084

RESUMEN

OBJECTIVES: Increased numbers of pertussis cases in September 2015 led to the declaration of an outbreak in the Saskatoon Health Region (SHR). SHR (population approximately 350,000) is a geographic area in central Saskatchewan consisting of both urban and rural municipalities. The purpose of this study was to describe the epidemiology and identify possible predictors of the outbreak. METHODS: Confirmed cases of pertussis in SHR from 2010 to 2015 were extracted from the integrated Public Health Information System (iPHIS) database. Univariate and bivariate analyses and a comparison of the two outbreaks were conducted. Poisson regression modelling was used to estimate incidence rate ratios (IRRs) of factors associated with pertussis infection. OUTCOMES: Two outbreaks between 2010 and 2015. Factors associated with the 2015 outbreak were residence in rural areas (IRR = 18.67, 95% CI 11.82-29.49; 11.37, 95% CI 6.40-20.21; and 6.31, 95% CI 3.43-11.62) for Humboldt, Watrous, and Rosthern areas, respectively, compared to the City of Saskatoon, and among children 11-14 years of age (IRR = 3.11, 95% CI 1.67-5.79) compared to children under 5 years of age. Unvaccinated persons had increased risk (IRR = 1.60, 95% CI 1.07-2.38). Multiple interventions, including enhanced contact tracing, supplemental immunization clinics, and cocooning, were employed in the 2015 outbreak. CONCLUSION: Pertussis is a cyclical disease with outbreaks occurring every 3 to 5 years. Teenagers have increased risk of disease compared to younger children, likely due to waning immunity. Rural residents had a higher incidence of disease, possibly due to clusters of conscientious objectors. Control efforts require recognition of waning immunity and unvaccinated susceptibles.


Asunto(s)
Brotes de Enfermedades , Población Rural , Población Urbana , Tos Ferina/epidemiología , Adolescente , Adulto , Anciano , Anciano de 80 o más Años , Niño , Preescolar , Ciudades , Femenino , Sistemas de Información en Salud , Humanos , Incidencia , Lactante , Masculino , Persona de Mediana Edad , Factores de Riesgo , Población Rural/estadística & datos numéricos , Saskatchewan/epidemiología , Población Urbana/estadística & datos numéricos , Adulto Joven
16.
Can J Public Health ; 109(5-6): 810-820, 2018 12.
Artículo en Inglés | MEDLINE | ID: mdl-29981109

RESUMEN

OBJECTIVE: A small proportion of the population accounts for the majority of healthcare costs. Mental health and addiction (MHA) patients are consistently high-cost. We aimed to delineate factors amenable to public health action that may reduce high-cost use among a cohort of MHA clients in Saskatoon, Saskatchewan. METHODS: We conducted a population-based retrospective cohort study. Administrative health data from fiscal years (FY) 2009-2015, linked at the individual level, were analyzed (n = 129,932). The outcome of interest was ≥ 90th percentile of costs for each year under study ('persistent high-cost use'). Descriptive analyses were followed by logistic regression modelling; the latter excluded long-term care residents. RESULTS: The average healthcare cost among study cohort members in FY 2009 was ~ $2300; for high-cost users it was ~ $19,000. Individuals with unstable housing and hospitalization(s) had increased risk of persistent high-cost use; both of these effects were more pronounced as comorbidities increased. Patients with schizophrenia, particularly those under 50 years old, had increased probability of persistent high-cost use. The probability of persistent high-cost use decreased with good connection to a primary care provider; this effect was more pronounced as the number of mental health conditions increased. CONCLUSION: Despite constituting only 5% of the study cohort, persistent high-cost MHA clients (n = 6455) accounted for ~ 35% of total costs. Efforts to reduce high-cost use should focus on reduction of multimorbidity, connection to a primary care provider (particularly for those with more than one MHA), young patients with schizophrenia, and adequately addressing housing stability.


Asunto(s)
Costos de la Atención en Salud/estadística & datos numéricos , Trastornos Mentales/economía , Determinantes Sociales de la Salud , Adulto , Anciano , Femenino , Humanos , Masculino , Persona de Mediana Edad , Estudios Retrospectivos , Factores de Riesgo , Saskatchewan , Factores Socioeconómicos
17.
Can Vet J ; 59(6): 617-622, 2018 06.
Artículo en Inglés | MEDLINE | ID: mdl-29910475

RESUMEN

Clinical isolates are important to antimicrobial resistance surveillance efforts because clinically ill animals are the direct targets of antimicrobial treatments. Thus, clinical data may provide a surveillance tool for identifying emerging resistance threats. The purpose of this study was to describe resistance trends in Escherichia coli and Salmonella spp. from clinically ill animals over time and evaluate the utility of these laboratory data as a passive surveillance tool. Susceptibility results of isolates from chickens, swine, and cattle recovered between 2007 and 2015 at a major veterinary diagnostic laboratory in Ontario, Canada were analyzed. Relative to other antimicrobials tested, visible trends highlighted high resistance to ampicillin and tetracycline in chicken E. coli, consistently high resistance to tetracycline, sulfisoxazole, and ampicillin among swine isolates, and an increase in cattle E. coli resistant to ampicillin and cephalothin over time. While the data show potential for use in surveillance, there are limitations of such a clinical dataset for predicting overall trends and guiding empirical treatment decisions.


Surveillance passive de l'antibiorésistance dans les isolats de Salmonella et d'Escherichia coli chez le bétail de l'Ontario, 2007­2015. Les isolats cliniques sont importants pour la surveillance de l'antibiorésistance parce que les animaux cliniquement malades sont les cibles directes des traitements antimicrobiens. Par conséquent, les données cliniques peuvent fournir un outil de surveillance pour identifier les nouvelles menaces de résistance. Le but de cette étude consistait à décrire dans le temps les tendances de résistance d'Escherichia coli et de Salmonella spp. chez les animaux cliniquement malades et d'évaluer l'utilité de ces données de laboratoire en tant qu'outil de surveillance passive. On a analysé les résultats de susceptibilité des isolats récupérés entre 2007 et 2015 auprès de poulets, de porcs et de bovins dans un grand laboratoire de diagnostic vétérinaire en Ontario, au Canada. Pour les antimicrobiens testés, les tendances visibles ont souligné une résistance importante d'E. coli à l'ampicilline et à la tétracycline chez les poulets, une résistance importante constante à la tétracycline, au sulfisoxazole et à l'ampicilline parmi les isolats des porcs et, chez les bovins, une progression d'E. coli résistant à l'ampicilline et à la céphalothine dans le temps. Même si les données montrent un potentiel d'utilisation pour la surveillance, il y a des limitations pour un tel ensemble de données cliniques en vue de la prédiction des tendances générales et de l'orientation des décisions de traitement empiriques.(Traduit par Isabelle Vallières).


Asunto(s)
Antiinfecciosos , Farmacorresistencia Bacteriana , Escherichia coli/efectos de los fármacos , Ganado/microbiología , Salmonella/efectos de los fármacos , Animales , Bovinos , Pollos , Pruebas de Sensibilidad Microbiana/veterinaria , Ontario , Prevalencia , Porcinos
18.
Support Care Cancer ; 26(7): 2267-2273, 2018 Jul.
Artículo en Inglés | MEDLINE | ID: mdl-29396594

RESUMEN

Cancer is a major public health problem, and cancer patients and survivors face many physical and emotional challenges after the initial diagnosis, through treatment, and in the post-treatment period. Different integrative medicine (IM) modalities can be used to mitigate some of the physical issues that originate from the cancer itself or the treatment and to promote well-being and emotional health. Here, we discuss how an IM Department can function in a hospital system, particularly with regard to oncology patients, the modalities appropriate for oncology patients, how these modalities can benefit this patient population, and the role of IM in cancer survivorship. A dedicated IM Department that works with oncologists provides support and care for the whole person. These different modalities work together to reduce pain, anxiety, and chemotherapy-induced nausea and peripheral neuropathy, while promoting immune function and improving sleep, range of motion, and an overall sense of well-being. However, each modality has different contraindications for the oncology patient, and proper training is required for safe and effective care. We illustrate how IM can be a valuable component of the care of the oncology patient.


Asunto(s)
Medicina Integrativa/métodos , Oncología Médica/métodos , Neoplasias/terapia , Humanos
19.
Food Funct ; 8(8): 2915-2923, 2017 Aug 01.
Artículo en Inglés | MEDLINE | ID: mdl-28740990

RESUMEN

An increased permeability of the intestinal barrier is proposed as a major event in the pathophysiology of conditions characterized by chronic gut inflammation. This study investigated the capacity of pure anthocyanins (AC), and berry and rice extracts containing different types and amounts of AC, to inhibit tumor necrosis alpha (TNFα)-induced permeabilization of Caco-2 cell monolayers. Caco-2 cells differentiated into intestinal epithelial cell monolayers were incubated in the absence/presence of TNFα, with or without the addition of AC or AC-rich plant extracts (ACRE). AC and ACRE inhibited TNFα-induced loss of monolayer permeability as assessed by changes in transepithelial electrical resistance (TEER) and paracellular transport of FITC-dextran. In the range of concentrations tested (0.25-1 µM), O-glucosides of cyanidin, and delphinidin, but not those of malvidin, peonidin and petunidin protected the monolayer from TNFα-induced decrease of TEER and increase of FITC-dextran permeability. Cyanidin and delphinidin acted by mitigating TNFα-triggered activation of transcription factor NF-κB, and downstream phosphorylation of myosin light chain (MLC). The protective actions of the ACRE on TNFα-induced TEER increase was positively correlated with the sum of cyanidins and delphinidins (r2 = 0.83) content in the ACRE. However, no correlation was observed between TEER and ACRE total AC, malvidin, or peonidin content. Results support a particular capacity of cyanidins and delphinidins in the protection of the intestinal barrier against inflammation-induced permeabilization, in part through the inhibition of the NF-κB pathway.


Asunto(s)
Antocianinas/farmacología , Sustancias Protectoras/farmacología , Uniones Estrechas/efectos de los fármacos , Factor de Necrosis Tumoral alfa/inmunología , Células CACO-2 , Permeabilidad de la Membrana Celular/efectos de los fármacos , Células Epiteliales/efectos de los fármacos , Células Epiteliales/inmunología , Humanos , Cadenas Ligeras de Miosina/genética , Cadenas Ligeras de Miosina/inmunología , FN-kappa B/genética , FN-kappa B/inmunología , Uniones Estrechas/inmunología , Factor de Necrosis Tumoral alfa/genética
20.
Can Vet J ; 57(3): 282-8, 2016 Mar.
Artículo en Inglés | MEDLINE | ID: mdl-26933265

RESUMEN

The objective of this study was to describe the perceived importance of and barriers to hand hygiene among companion animal clinic staff. An anonymous, voluntary written questionnaire was completed by 356 of approximately 578 individuals (62%) from 49/51 clinics. On a scale of 1 (not important) to 7 (very important), the percentage of respondents who rated hand hygiene as a 5 or higher was at least 82% in all clinical scenarios queried. The most frequently reported reason for not performing hand hygiene was forgetting to do so (40%, 141/353). Specific discussion of hand hygiene practices at work was recalled by 32% (114/354) of respondents. Although veterinary staff seem to recognize the importance of hand hygiene, it should be emphasized more during staff training. Other barriers including time constraints and skin irritation should also be addressed, possibly through increased access to and use of alcohol-based hand sanitizers.


Perceptions et obstacles autodéclarés pour l'hygiène des mains parmi les employés des cliniques vétérinaires pour animaux de compagnie en Ontario, au Canada. L'objectif de cette étude consistait à décrire l'importance perçue des obstacles à l'hygiène des mains, ainsi que les obstacles eux-mêmes, parmi les employés des cliniques pour animaux de compagnie. Un questionnaire écrit volontaire et anonyme a été rempli par 356 personnes parmi un groupe d'environ 578 individus (62 %) provenant de 49/51 cliniques. Sur une échelle de 1 (pas important) à 7 (très important), le pourcentage des répondants qui a évalué l'hygiène des mains avec une cote de 5 ou supérieure était d'au moins 82 % dans tous les scénarios cliniques présentés. La raison la plus fréquente de ne pas effectuer l'hygiène des mains était l'oubli (40 %, 141/353). Signalons que 32 % (114/354) des répondants se sont rappelés d'une discussion spécifique sur les pratiques d'hygiène des mains au travail. Même si le personnel vétérinaire semble reconnaître l'importance de l'hygiène des mains, il faudrait insister plus sur ce sujet lors de la formation des employés. Les autres obstacles, qui incluent les contraintes de temps et l'irritation de la peau, devraient aussi être abordés, potentiellement par l'accès et l'utilisation accrus de désinfectants à base d'alcool.(Traduit par Isabelle Vallières).


Asunto(s)
Técnicos de Animales , Higiene de las Manos , Hospitales Veterinarios , Mascotas , Veterinarios , Adolescente , Adulto , Anciano , Animales , Femenino , Encuestas de Atención de la Salud , Conocimientos, Actitudes y Práctica en Salud , Humanos , Masculino , Persona de Mediana Edad , Ontario , Percepción , Autoinforme , Adulto Joven
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