Your browser doesn't support javascript.
loading
Mostrar: 20 | 50 | 100
Resultados 1 - 1 de 1
Filtrar
Más filtros











Base de datos
Intervalo de año de publicación
1.
Toxicol Lett ; 225(1): 20-6, 2014 Feb 10.
Artículo en Inglés | MEDLINE | ID: mdl-24296008

RESUMEN

Quantum dots exhibit extraordinary optical and mechanical properties, and the number of their applications is increasing. In order to investigate a possible effect of coating on the inhalation toxicity of previously tested non-coated CdS/Cd(OH)2 quantum dots and translocation of these very small particles from the lungs, rats were exposed to coated quantum dots or CdCl2 aerosol (since Cd(2+) was present as impurity), 6h/d for 5 consecutive days. Cd content was determined in organs and excreta after the end of exposure and three weeks thereafter. Toxicity was determined by examination of broncho-alveolar lavage fluid and microscopic evaluation of the entire respiratory tract. There was no evidence for translocation of particles from the respiratory tract. Evidence of a minimal inflammatory process was observed by examination of broncho-alveolar lavage fluid. Microscopically, minimal to mild epithelial alteration was seen in the larynx. The effects observed with coated quantum dots, non-coated quantum dots and CdCl2 were comparable, indicating that quantum dots elicited no significant effects beyond the toxicity of the Cd(2+) ion itself. Compared to other compounds with larger particle size tested at similarly low concentrations, quantum dots caused much less pronounced toxicological effects. Therefore, the present data show that small particle sizes with corresponding high surfaces are not the only factor triggering the toxic response or translocation.


Asunto(s)
Compuestos de Cadmio/toxicidad , Glutaral/toxicidad , Hidróxidos/toxicidad , Puntos Cuánticos/toxicidad , Sistema Respiratorio/efectos de los fármacos , Sulfuros/toxicidad , Aerosoles , Animales , Líquido del Lavado Bronquioalveolar , Cloruro de Cadmio/toxicidad , Compuestos de Cadmio/metabolismo , Compuestos de Cadmio/orina , Heces/química , Glutaral/metabolismo , Glutaral/orina , Hidróxidos/metabolismo , Hidróxidos/orina , Exposición por Inhalación , Masculino , Tamaño de la Partícula , Puntos Cuánticos/metabolismo , Ratas , Ratas Wistar , Sistema Respiratorio/metabolismo , Sistema Respiratorio/patología , Sulfuros/metabolismo , Sulfuros/orina , Factores de Tiempo , Distribución Tisular , Pruebas de Toxicidad Aguda
SELECCIÓN DE REFERENCIAS
DETALLE DE LA BÚSQUEDA