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AIM: To determine variables associated with hyperglycemia and insulin therapy in postoperative inpatients with diabetes mellitus following a quality-improvement initiative. MATERIALS & METHODS: Patients with diabetes mellitus following an elective surgical procedure (n = 782; 877 surgical procedures) were selected. RESULTS: Age, hemoglobin A1c corticosteroids, insulin therapy and year of surgery were associated (p < 0.01) with hyperglycemia. Hemoglobin A1c, hyperglycemia, case mix index and corticosteroids were associated (p ≤ 0.03) with insulin therapy. Hyperglycemia and use of insulin varied by surgical specialty. CONCLUSION: Data could be used to modify current treatment algorithms. Variations in hyperglycemia and insulin use by surgical specialty require further investigation.
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BACKGROUND: This study evaluated referral patterns for preoperative evaluations of patients with poorly controlled diabetes mellitus (DM) and determined whether intervals between evaluations and surgery day were associated with preoperative glucose levels. RESULTS/METHODOLOGY: In this retrospective analysis of DM patients with a hemoglobin A1c level greater than 8.0%, of the 163 patients who underwent preoperative medical evaluation, only 45% were evaluated by endocrinology. Patients who had surgery earlier than 10 days after the preoperative medical evaluation had preoperative glucose levels 18% higher than those of patients who waited more than 10 days. Preoperative outpatient contact with endocrinology was not associated with preoperative glucose level (p = 0.90). CONCLUSION: For poorly controlled DM, more than 10 days are needed to achieve preoperative glycemic control.
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Diabetes mellitus (DM) and hyperglycemia are associated with increased surgical morbidity and mortality. Hyperglycemia is a determinant of risk of surgical complications and should be addressed across the continuum of surgical care. While data support the need to address hyperglycemia in patients with DM in the ambulatory setting prior to surgery and in the inpatient setting, data are less certain about hyperglycemia occurring during the perioperative period-that part of the process occurring on the day of surgery itself. The definition of "perioperative" varies in the literature. This paper proposes a standardized definition for the perioperative period as spanning the time of patient admission to the preoperative area through discharge from the recovery area. Available information about the impact of perioperative hyperglycemia on surgical outcomes within the framework of that definition is summarized, and the authors' approach to standardizing perioperative care for patients with DM is outlined, including the special case of patients receiving insulin pump therapy. The discussion is limited to adult ambulatory non-obstetric patients undergoing elective surgical procedures under general anesthesia.
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Diabetes Mellitus/cirugía , Procedimientos Quirúrgicos Electivos , Hiperglucemia/cirugía , Humanos , Insulina/uso terapéutico , Alta del Paciente , Periodo Perioperatorio , Resultado del TratamientoRESUMEN
OBJECTIVE: Assess the impact of guidelines on the care of patients with diabetes undergoing elective surgery. METHODS: A multidisciplinary team developed perioperative guidelines. Overall changes in key measures were evaluated after guidelines were introduced and compared with a historical cohort. RESULTS: The historical cohort included 254 surgical procedures, and the post-guidelines implementation cohort comprised 1,387. Glucose monitoring was performed preoperatively in 93% of cases in the post-guidelines implementation cohort and in 88% in the historical cohort (P<.01), but the percentage of cases with measurements decreased over 12 months (from 95% to 91%, P = .044). Glucose was intraoperatively monitored in 67% of cases after guidelines were introduced and in 29% historically (P<.01); the post-guidelines implementation percentage decreased over 12 months from 67% to 55% (P<.01). The performance of glucose monitoring in the postanesthesia care unit (PACU) did not differ (86% vs. 87%, P = .57), but it decreased over 12 months, from 91% to 84% (P<.01). After introduction of the guidelines, insulin use increased in the preoperative, intraoperative, and PACU areas (all P≤.01) but decreased by the end of 12 months (all P<.01). Mean preoperative and PACU glucose levels in the post- guidelines implementation cohort were significantly lower than in the historical cohort (P<.01). CONCLUSION: Multidisciplinary management guidelines for diabetes patients undergoing surgery can improve the performance of key measures of care. Although adherence to recommendations generally remained higher after guideline implementation than in the historical period, the improvement in several measures began to decline over time.
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Diabetes Mellitus/sangre , Procedimientos Quirúrgicos Electivos/métodos , Cuidados Intraoperatorios/métodos , Complicaciones Intraoperatorias/prevención & control , Anciano , Anestesia , Glucemia/análisis , Diabetes Mellitus/tratamiento farmacológico , Femenino , Hemoglobina Glucada/análisis , Estado de Salud , Humanos , Insulina/administración & dosificación , Comunicación Interdisciplinaria , Masculino , Persona de Mediana Edad , Cuidados Posoperatorios , Guías de Práctica Clínica como Asunto , Cuidados Preoperatorios/métodosRESUMEN
OBJECTIVE: The objective of the analysis was to review the effectiveness of a care process model (CPM) developed to guide management of patients on insulin pump therapy undergoing elective surgical procedures. METHODS: Electronic medical records were reviewed to assess the impact of the CPM on documentation of insulin pump status, glucose monitoring, and safety during the perioperative phase of care. Post-CPM care was compared with management provided before CPM implementation. RESULTS: We reviewed 45 cases on insulin pump therapy in the pre-CPM cohort and 106 in the post-CPM cohort. Demographic characteristics, categories of surgery, and perioperative times were not significantly different between the 2 groups. Recommended hemoglobin A1c monitoring occurred in 73% of cases in the pre-CPM cohort but improved to 94% in the post-CPM group (P < .01). There was a higher frequency of documentation of the insulin pump during the preoperative, intraoperative, and postanesthesia care unit segments of care in the post- vs pre-CPM periods (all P < .01). The number of cases with intraoperative glucose monitoring increased (57% pre-CPM vs 81% post-CPM; P < .01). Glycemic control was comparable between the 2 CPM periods. Hypoglycemia was rare, with only 3 episodes in the pre-CPM group and 4 in the post-CPM. No adverse events associated with perioperative insulin pump use were observed. CONCLUSIONS: This analysis adds to previous data on use of insulin pump therapy during the perioperative period. Some processes require additional attention, but data continue to indicate that a standardized approach to care can lead to a successful and safe transition of insulin pump therapy throughout the perioperative period.
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Hipoglucemiantes/administración & dosificación , Sistemas de Infusión de Insulina/normas , Insulina/administración & dosificación , Atención Perioperativa/normas , Mejoramiento de la Calidad/normas , Indicadores de Calidad de la Atención de Salud/normas , Adulto , Anciano , Biomarcadores/sangre , Glucemia/efectos de los fármacos , Glucemia/metabolismo , Procedimientos Quirúrgicos Electivos , Registros Electrónicos de Salud , Femenino , Hemoglobina Glucada/metabolismo , Humanos , Hipoglucemia/sangre , Hipoglucemia/inducido químicamente , Hipoglucemiantes/efectos adversos , Infusiones Subcutáneas , Insulina/efectos adversos , Sistemas de Infusión de Insulina/efectos adversos , Masculino , Persona de Mediana Edad , Monitoreo Intraoperatorio/normas , Seguridad del Paciente/normas , Evaluación de Programas y Proyectos de Salud , Factores de RiesgoRESUMEN
OBJECTIVE: To assess the impact of an intervention designed to increase basal-bolus insulin therapy administration in postoperative patients with diabetes mellitus. METHODS: Educational sessions and direct support for surgical services were provided by a nurse practitioner (NP). Outcome data from the intervention were compared to data from a historical (control) period. Changes in basal-bolus insulin use were assessed according to hyperglycemia severity as defined by the percentage of glucose measurements >180 mg/dL. RESULTS: Patient characteristics were comparable for the control and intervention periods (all P≥.15). Overall, administration of basal-bolus insulin occurred in 9% (8/93) of control and in 32% (94/293) of intervention cases (P<.01). During the control period, administration of basal-bolus insulin did not increase with more frequent hyperglycemia (P = .22). During the intervention period, administration increased from 8% (8/96) in patients with the fewest number of hyperglycemic measurements to 60% (57/95) in those with the highest frequency of hyperglycemia (P<.01). The mean glucose level was lower during the intervention period compared to the control period (149 mg/dL vs. 163 mg/dL, P<.01). The proportion of glucose values >180 mg/dL was lower during the intervention period than in the control period (21% vs. 31% of measurements, respectively, P<.01), whereas the hypoglycemia (glucose >70 mg/dL) frequencies were comparable (P = .21). CONCLUSION: An intervention to overcome clinical inertia in the management of postoperative patients with diabetes led to greater utilization of basal-bolus insulin therapy and improved glucose control without increasing hypoglycemia. These efforts are ongoing to ensure the delivery of effective inpatient diabetes care by all surgical services.
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Diabetes Mellitus/tratamiento farmacológico , Insulina/uso terapéutico , Cuidados Posoperatorios , Anciano , Glucemia/análisis , Diabetes Mellitus/sangre , Femenino , Humanos , Masculino , Persona de Mediana EdadRESUMEN
OBJECTIVE: Our objective was to assess the application of insulin regimens in surgical postoperative patients with diabetes. METHODS: A chart review was conducted of patients with diabetes who were hospitalized postoperatively between January 1 and April 30, 2011. Analysis was restricted to patients hospitalized for ≥3 days and excluded cases with an endocrinology consult. Insulin regimens were categorized as "basal plus short acting," "short acting only," or "none," and the pattern of use was evaluated by hyperglycemia severity according to tertiles of both mean glucose and the number of glucose measurements >180 mg/dl. RESULTS: Among cases selected for analysis (n = 119), examination of changes in insulin use based on tertiles of mean glucose showed that use of basal plus short-acting insulin increased from 10% in the lowest tertile (mean glucose, 120 mg/dl) to 18% in the highest tertile (mean glucose, 198 mg/dl; p < .01); however, 70% of patients in the highest tertile continued to receive short-acting insulin only, with 12% receiving no insulin. Intensification of insulin to a basal plus short-acting regimen was also seen when changes were evaluated by the number of measurements >180 mg/dl (p < .01), but 70% and 12% of patients in the highest tertile still remained only on short-acting insulin or received no insulin, respectively. CONCLUSIONS: Use of basal plus short-acting insulin therapy increased with worsening hyperglycemia, but many cases did not have therapy intensified to the recommended insulin regimen--evidence of clinical inertia. Strategies should be devised to overcome inpatient clinical inertia in the treatment of postoperative patients with diabetes.
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Competencia Clínica/estadística & datos numéricos , Complicaciones de la Diabetes/tratamiento farmacológico , Diabetes Mellitus/sangre , Diabetes Mellitus/cirugía , Hiperglucemia/tratamiento farmacológico , Insulina/administración & dosificación , Cuidados Posoperatorios/normas , Anciano , Glucemia/análisis , Glucemia/efectos de los fármacos , Complicaciones de la Diabetes/epidemiología , Complicaciones de la Diabetes/etiología , Relación Dosis-Respuesta a Droga , Femenino , Humanos , Hiperglucemia/epidemiología , Pacientes Internos/estadística & datos numéricos , Masculino , Persona de Mediana Edad , Cuidados Posoperatorios/estadística & datos numéricos , Periodo Posoperatorio , Estudios Retrospectivos , Factores de TiempoRESUMEN
Case reports indicate that diabetes patients receiving outpatient insulin pump therapy have been allowed to continue treatment during surgical procedures. Although allowed during surgery, there is actually little information in the medical literature on how to manage patients receiving insulin pump therapy during a planned surgical procedure. A multidisciplinary work group reviewed current information regarding the use of insulin pumps in the perioperative period. Although the work group identified safety issues specific to surgical scenarios, it believed that with the use of standardized guidelines and a checklist, continuation of insulin pump therapy during the perioperative period is feasible. A sample set of protocols have been developed and are summarized. A policy outlining clear procedures should be established at the institutional level to guide physicians and other staff if the devices are to be employed during the perioperative period. Additional clinical experience with the technology in surgical scenarios is needed, and consensus should be developed for insulin pump use in the perioperative phases of care.
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Sistemas de Infusión de Insulina/estadística & datos numéricos , Insulina/administración & dosificación , Periodo Perioperatorio , Guías de Práctica Clínica como Asunto , Lista de Verificación/métodos , Lista de Verificación/normas , Diabetes Mellitus/tratamiento farmacológico , Diabetes Mellitus/cirugía , Humanos , Hipoglucemiantes/administración & dosificación , Infusiones Subcutáneas , Sistemas de Infusión de Insulina/normas , Periodo Perioperatorio/métodos , Nivel de Atención/legislación & jurisprudenciaRESUMEN
BACKGROUND: Obesity has been linked to many adverse health consequences, including breast cancer; however, the impact on clinical presentation, tumor characteristics, and survival outcomes has yet to be clearly defined. METHODS: Retrospective review of a prospectively collected database of patients treated at a single institution for invasive breast cancer from 2000-2008 comparing two groups: nonobese (body mass index of <30) and obese (body mass index of ≥ 30) patients. Continuous variables, categorical variables, and survival data were analyzed. RESULTS: Of 1352 total patients, 76% were classified as nonobese and 24% were obese. When comparing age, obese patients presented less frequently than nonobese patients <50 years old (10% vs. 90%), and when comparing patients >50 years old (18% vs. 82%, P = 0.0019). Obese patients were more likely to present with disease detected by imaging when compared to nonobese patients (67% vs. 56%, P = 0.0006). Obese patients had larger tumors (1.7 cm vs. 1.4 cm, P < 0.001) and higher rates of lymph node (LN) metastases (31% vs. 25%, P = 0.026). On multivariate analysis, obesity was associated with nonpalpable tumors, larger tumors, a higher incidence of LN metastasis, lower incidence of Her2 positivity, lower incidence of multifocality, and less likely to undergo reconstruction after mastectomy. CONCLUSIONS: Obese patients clinically present at older ages with mammographically detected breast cancer at more advanced stages than nonobese patients. Strategies to encourage screening among the obese patient population are important.
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Índice de Masa Corporal , Neoplasias de la Mama/diagnóstico , Carcinoma Ductal de Mama/diagnóstico , Obesidad/complicaciones , Adulto , Factores de Edad , Anciano , Anciano de 80 o más Años , Análisis de Varianza , Neoplasias de la Mama/complicaciones , Neoplasias de la Mama/metabolismo , Carcinoma Ductal de Mama/complicaciones , Carcinoma Ductal de Mama/metabolismo , Carcinoma Ductal de Mama/secundario , Distribución de Chi-Cuadrado , Femenino , Humanos , Estimación de Kaplan-Meier , Metástasis Linfática , Mamoplastia , Mamografía , Persona de Mediana Edad , Análisis Multivariante , Modelos de Riesgos Proporcionales , Receptor ErbB-2/metabolismo , Estudios Retrospectivos , Adulto JovenRESUMEN
OBJECTIVE: To assess perioperative management of patients with diabetes mellitus who were being treated with insulin pump therapy. METHODS: We reviewed records for documentation of insulin pump status and glucose monitoring during preoperative, intraoperative, and postanesthesia care unit (PACU) phases of surgery. RESULTS: Thirty-five patients (21 men) with insulin pumps underwent surgical procedures between January 1, 2006, and December 31, 2010. Mean age was 56 years, mean diabetes duration was 31 years, and mean duration of insulin pump therapy was 7 years. All patients were white, and 29 had type 1 diabetes mellitus. Of the 50 surgical procedures performed during the study period, 16 were orthopedic, 9 were general surgical, 7 were urologic, and 7 were kidney transplant operations; the remaining 11 procedures were in other surgical specialties. The mean (± standard deviation) time in the preoperative area was 118 ± 75 minutes, mean intraoperative time was 177 ± 102 minutes, and mean PACU time was 170 ± 78 minutes. Of the 50 procedures, status of pump use was documented in 32 cases in the preoperative area, 14 cases intraoperatively, and 30 cases in the PACU. Glucose values were recorded in 47 cases preoperatively, 30 cases intraoperatively, and 48 cases in the PACU. CONCLUSIONS: Results showed inconsistent documentation of pump use and glucose monitoring throughout the perioperative period, even for patients with prolonged anesthesia and recovery times. It was often unclear whether the pump was in place and operational during the intraoperative period. Guidelines should be developed for management of insulin pump-treated patients who are to undergo surgery.
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Complicaciones de la Diabetes/terapia , Diabetes Mellitus/tratamiento farmacológico , Sistemas de Infusión de Insulina , Procedimientos Quirúrgicos Operativos , Periodo de Recuperación de la Anestesia , Glucemia/análisis , Cuidados Críticos , Interpretación Estadística de Datos , Documentación , Femenino , Humanos , Hipoglucemiantes/administración & dosificación , Hipoglucemiantes/efectos adversos , Hipoglucemiantes/uso terapéutico , Insulina/administración & dosificación , Insulina/efectos adversos , Insulina/uso terapéutico , Sistemas de Infusión de Insulina/efectos adversos , Cuidados Intraoperatorios , Masculino , Persona de Mediana Edad , Cuidados PreoperatoriosRESUMEN
BACKGROUND: Although mammography is the gold standard for breast cancer screening, clinical breast examination (CBE) and self breast examination (SBE) are important adjuncts whose utility has been questioned. METHODS: A retrospective review of invasive breast cancer patients from 2000 to 2008 was performed. We compared 3 groups: breast cancer detected by (1) imaging only (nonpalpable) or palpable mass with a normal mammogram (2) ≥ 1 year (mammogram ≥ 1 year) or (3) <1 year (mammogram <1 year). RESULTS: Of 1,222 women, presentation included 67% nonpalpable, 21% mammogram ≥ 1 year, and 13% mammogram <1 year. Patients presenting with palpable masses on SBE or CBE even with a normal mammogram within 1 year tended to have more aggressive tumors (larger size, lymph node positive, and triple-negative disease) resulting in more aggressive therapy (a higher mastectomy rate and a greater likelihood of chemotherapy). CONCLUSION: A significant number of women present with palpable breast cancer within 1 year of a normal mammogram, many with an aggressive cancer. Therefore, we continue to advocate SBE and CBE for breast cancer screening.
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Neoplasias de la Mama/diagnóstico , Mamografía , Palpación , Adulto , Anciano , Anciano de 80 o más Años , Biomarcadores de Tumor/análisis , Neoplasias de la Mama/diagnóstico por imagen , Neoplasias de la Mama/terapia , Autoexamen de Mamas , Detección Precoz del Cáncer , Femenino , Humanos , Persona de Mediana EdadRESUMEN
BACKGROUND: The accuracy of magnetic resonance imaging (MRI) in identifying residual disease after breast conservation therapy (BCT) is unclear. METHOD: Review of an institutional database identified patients with positive or close (Asunto(s)
Neoplasias de la Mama/diagnóstico
, Imagen por Resonancia Magnética
, Neoplasia Residual/diagnóstico
, Adulto
, Anciano
, Anciano de 80 o más Años
, Neoplasias de la Mama/cirugía
, Femenino
, Humanos
, Mastectomía Segmentaria
, Persona de Mediana Edad
, Valor Predictivo de las Pruebas
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BACKGROUND: Treating hyperglycemia promotes better outcomes among inpatients. Knowledge deficits about management of inpatient diabetes are prevalent among resident physicians, which may affect the care of a substantial number of these patients. METHODS: A computer-based training (CBT) curriculum on inpatient diabetes and hyperglycemia was developed and implemented for use by resident physicians and focuses on several aspects of the management of inpatient diabetes and hyperglycemia: (1) review of importance of inpatient glucose control, (2) overview of institution-specific data, (3) triaging and initial admission actions for diabetes or hyperglycemia, (4) overview of pharmacologic management, (5) insulin-dosing calculations and ordering simulations, (6) review of existing policies and procedures, and (7) discharge planning. The curriculum was first provided as a series of lectures, then formatted and placed on the institutional intranet as a CBT program. RESULTS: Residents began using the inpatient CBT in September 2008. By August 2009, a total of 29 residents had participated in CBT: 8 in family medicine, 12 in internal medicine, and 9 in general surgery. Most of the 29 residents confirmed that module content met stated objectives, considered the information valuable to their inpatient practices, and believed that the quality of the online modules met expectations. The majority reported that the modules took just the right amount of time to complete (typically 30 min each). CONCLUSIONS: Improvement in inpatient diabetes care requires continuous educational efforts. The CBT format and curriculum content were well accepted by the resident physicians. Ongoing assessment must determine whether resident practice patterns are influenced by such training.