1.
Bioorg Med Chem Lett
; 19(7): 2038-43, 2009 Apr 01.
Artículo
en Inglés
| MEDLINE
| ID: mdl-19251414
RESUMEN
A novel series of semi-synthetic trioxaquines and synthetic trioxolaquines were prepared, in moderate to good yields. Antimalarial activity was evaluated against both the chloroquine-sensitive 3D7 and resistant K1 strain of Plasmodium falciparum and both series of compounds were shown to be active in the low nanomolar range. For comparison the corresponding 9-amino acridine analogues were also prepared and shown to have low nanomolar activity like their quinoline counterparts.