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An Acad Bras Cienc ; 88(3 Suppl): 1889-1897, 2016.
Artículo en Inglés | MEDLINE | ID: mdl-27901193

RESUMEN

This study analyzed the physicochemical and photophysical properties of essential oil of Curcuma longa and its angiogenic potential. The results showed that curcumin is the main fluorescent component present in the oil, although the amount is relatively small. The experimental chorioallantoic membrane model was used to evaluate angiogenic activity, showing a significant increase in the vascular network of Curcuma longa and positive control groups when compared to the neutral and inhibitor controls (P <0.05), but no significant difference was found between Curcuma longa essential oil and the positive control (P >0.05). Histological analysis showed extensive neovascularization, hyperemia and inflammation in the positive control group and Curcuma longa when compared to other controls (P <0.05), characteristic factors of the angiogenesis process. In conclusion, Curcuma longa oil showed considerable proangiogenic activity and could be a potential compound in medical applications.


Asunto(s)
Inductores de la Angiogénesis/farmacología , Curcuma/química , Neovascularización Fisiológica , Aceites Volátiles/química , Aceites Volátiles/farmacología , Aceites de Plantas/química , Aceites de Plantas/farmacología , Inductores de la Angiogénesis/química , Animales , Pollos , Membrana Corioalantoides/irrigación sanguínea , Membrana Corioalantoides/efectos de los fármacos , Curcumina/análisis , Hiperemia/inducido químicamente , Inflamación/inducido químicamente , Neovascularización Fisiológica/efectos de los fármacos
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