Understanding the Relationship between Social Cognition and Word Difficulty. A Language Based Analysis of Individuals with Autism Spectrum Disorder.

BACKGROUND: Few quantitative studies have been conducted on the relationship between society and its languages. Individuals with autistic spectrum disorder (ASD) are known to experience social hardships, and a wide range of clinical information about their quality of life has been provided through numerous narrative analyses. However, the narratives of ASD patients have thus far been examined mainly through qualitative approaches. OBJECTIVES: In this study, we analyzed adults with ASD to quantitatively examine the relationship between language abilities and ASD severity scores. METHODS: We generated phonetic transcriptions of speeches by 16 ASD adults at an ASD workshop, and divided the participants into 2 groups according to their Social Responsiveness Scale(TM), 2nd Edition (SRS(TM)-2) scores (where higher scores represent more severe ASD): Group A comprised high-scoring ASD adults (SRS(TM)-2 score: ≥ 76) and Group B comprised low- and intermediate-scoring ASD adults (SRS(TM)-2 score: < 76). Using natural language processing (NLP)-based analytical methods, the narratives were converted into numerical data according to four language ability indicators, and the relationships between the language ability scores and ASD severity scores were compared. RESULTS AND DISCUSSION: Group A showed a marginally negative correlation with the level of Japanese word difficulty (p < .10), while the "social cognition" subscale of the SRS(TM)-2 score showed a significantly negative correlation (p < .05) with word difficulty. When comparing only male participants, Group A demonstrated a significantly lower correlation with word difficulty level than Group B (p < .10). CONCLUSION: Social communication was found to be strongly associated with the level of word difficulty in speech. The clinical applications of these findings may be available in the near future, and there is a need for further detailed study on language metrics designed for ASD adults.

An easily implemented method for abbreviation expansion for the medical domain in Japanese text. A preliminary study.

BACKGROUND: One of the barriers for the effective use of computerized health-care related text is the ambiguity of abbreviations. To date, the task of disambiguating abbreviations has been treated as a classification task based on surrounding words. Application of this framework for languages that have no word boundaries requires pre-processing to segment a sentence into separate word sequences. While the segmentation processing is often a source of problem, it is unknown whether word information is really requisite for abbreviation expansion. OBJECTIVES: The present study examined and compared abbreviation expansion methods with and without the incorporation of word information as a preliminary study. METHODS: We implemented two abbreviation expansion methods: 1) a morpheme-based method that relied on word information and therefore required pre-processing, and 2) a character-based method that relied on simple character information. We compared the expansion accuracies for these two methods using eight medical abbreviations. Experimental data were automatically built as a pseudo-annotated corpus using the Internet. RESULTS: As a result of the experiment, accuracies for the character-based method were from 0.890 to 0.942 while accuracies for the morpheme-based method were from 0.796 to 0.932. The character-based method significantly outperformed the morpheme-based method for three of the eight abbreviations (p < 0.05). For the remaining five abbreviations, no significant differences were found between the two methods. CONCLUSIONS: Character information may be a good alternative in terms of simplicity to morphological information for abbreviation expansion in English medical abbreviations appeared in Japanese texts on the Internet.

Identification of lysine-238 of Escherichia coli biotin carboxylase as an ATP-binding residue.

Escherichia coli biotin carboxylase was affinity labeled with adenosine diphosphopyridoxal to identify its ATP binding site. Lysyl endopeptidase digestion of the modified protein, followed by high performance liquid chromatography separation and amino acid sequencing allowed to identify lysine-238 to be the site of modification. Site-directed mutagenesis of this residue into alanine, arginine or glutamine resulted in mutants with much decreased activity. Lysine-238 seems to interact with the gamma-phosphate group of ATP but is not involved in catalysis.