RESUMEN
PURPOSE: To analyze the effect of congenital ptosis on corneal topography and total aberrometry and to compare these variables between ptotic and normal fellow eyes. METHODS: The study included 32 eyes of 16 patients with unilateral congenital blepharoptosis. A Shack-Hartmann wavefront sensor was employed to assess Zernike coefficients and root-mean-square. Computerized corneal topography, Orbscan and aberrometry were measured in the healthy and ptotic eyes. Data were analyzed using SPSS version 16. P<0.05 was considered significant. RESULTS: The mean patient age was 21.31±6.3 years. The mean margin to light reflex distance-1 (MRD-1) was 0.6±1.44mm in the ptotic eyes. Among topography variables, surface regularity index (SRI), cylinder power, irregular astigmatism index (IAI), and flat meridian keratometry were significantly different between ptotic and non-ptotic fellow eyes (P<0.05). Some Orbscan parameters, including simulated keratometry, maximum and minimum corneal power, and astigmatism power were significantly different between ptotic and normal fellow eyes (P<0.05). There was no statistically significant difference in total aberrometry variables between paired eyes. However, in a comparison between ptotic eyes with over 1 diopter astigmatism vs. less than 1 D, high-order Zernike modes without spherical aberration at 6mm (HOW/O Z400 6mm) were significantly different between the 2 groups (P=0.02). CONCLUSION: Unilateral congenital ptosis significantly affects corneal topography and aberrometry, especially in eyes with astigmatism≥1 D. Such differences need to be considered before keratorefractive surgery (KRS).
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PURPOSE OF THE STUDY: to determine the efficacy, adverse effects and safety of a new Iranian generic product of deferasirox (Osveral®) in Iranian transfusion dependent major thalassemic (TD-MT) patients. METHODS: In 9 main thalassemia treatment centers, all of TD-MT patients (aged ≥2 yrs) with serum ferritin (SF) levels≥1000 ng/ml, or >100 ml/kg of RBC transfusion,who could not tolerate parental iron chelating were recruited regardless of their previous iron chelation therapy. Periodical clinical and laboratory evaluations were conducted for adverse effects (AEs). Primary efficacy end point was Mean of Relative Change of Serum Ferritin (MRC-SF) from the baseline level during one year. Analysis of variance (ANOVA), t test, chi-square or Fisher exact test were used for statistic analysis appropriately (P values <0.05 were considered as statistical significant). RESULTS: In 407 cases the male/female ratio was 0.98. Mean age was 11.5±7.4 (2-58) years. The mean of initiating dose of Osveral® and mean usage dose during the study was 23.5±4.9 mg/kg and 24.9±4.9 mg/kg respectively. MRC-SF was -11.44% ±38.92 and it showed significant decline in SF (P value<0.001) one hundred and forty eight patients out of 407 patients experienced at least one. AE, the most common of them were transient increase in serum creatinin (97;24.1%) and>5 time increase in transaminases (24;5.89%).The causes of discontinuation of treatment were non-satisfactory treatment ( 24; 5.8%), poor or non-compliance of patients (21;5.1%), and adverse effects (13; 3.1%) CONCLUSION: A detailed comparison with similar studies on deferasirox (Exjade®) shows a promising efficacy and safety for its Iranian generic product (Osveral ®).
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The Shiraz Organ Transplant Center in southern Iran has been performing all liver transplantations in Iran and certain neighboring countries for 12 years. This study evaluated the 140 operations performed from April 1993 through November 2004. Sixty-one percent of the recipients were men and 39% were women. The average recipient age was 29.9 +/- 14.0 years. One hundred twenty-eight patients has a full-size cadaveric transplant. Most frequent causes of cirrhosis were cryptogenic and viral. An acute rejection episode occurred in 47.5% of cases, and two episodes in 8%. Most frequent short-term complications included respiratory, neurologic, and biliary problems. The 1-, 2-, and 3-year patient survival rates were 92%, 89%, and 85%, respectively. The experience that the Shiraz Organ Transplant Center has had with liver transplantation indicated success comparable to that noted in other reports. The calculated trend suggests that a goal of 100 transplantations for 2005 is within reach.
Asunto(s)
Trasplante de Hígado/fisiología , Adolescente , Adulto , Femenino , Humanos , Irán , Hepatopatías/clasificación , Hepatopatías/cirugía , Trasplante de Hígado/métodos , Masculino , Estudios Retrospectivos , Resultado del TratamientoAsunto(s)
Trasplante de Hígado/métodos , Adolescente , Adulto , Cadáver , Niño , Preescolar , Familia , Femenino , Humanos , Irán , Trasplante de Hígado/mortalidad , Trasplante de Hígado/estadística & datos numéricos , Donadores Vivos , Masculino , Persona de Mediana Edad , Tasa de Supervivencia , Donantes de TejidosRESUMEN
A breast cancer screening programme was evaluated for approximately 10,000 women aged 35 years and older. There were 67 cases of breast cancer. Highest rates of attendance were seen among younger women (35-44 years) and middle socioeconomic groups. Lowest rates were among those aged over 65 years and low socioeconomic groups. The rate of detection by self-examination was similar to that by health personnel examination. At all stages of screening, positive findings were most common among the high socioeconomic class. Attendance decreased steadily from first to last stages of serial screening. Although mammography is the most sensitive method of detection, because of its high cost we suggest establishing breast self-examination education programmes and encouraging women to self-examine.
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Neoplasias de la Mama/diagnóstico , Tamizaje Masivo/métodos , Tamizaje Masivo/normas , Servicios Urbanos de Salud/organización & administración , Adulto , Distribución por Edad , Factores de Edad , Anciano , Neoplasias de la Mama/epidemiología , Autoexamen de Mamas/normas , Femenino , Costos de la Atención en Salud/estadística & datos numéricos , Educación en Salud , Investigación sobre Servicios de Salud , Humanos , Irán , Mamografía/normas , Tamizaje Masivo/economía , Tamizaje Masivo/estadística & datos numéricos , Persona de Mediana Edad , Evaluación de Necesidades , Aceptación de la Atención de Salud/psicología , Aceptación de la Atención de Salud/estadística & datos numéricos , Examen Físico/normas , Prevalencia , Evaluación de Programas y Proyectos de Salud , Sensibilidad y Especificidad , Factores SocioeconómicosRESUMEN
A breast cancer screening programme was evaluated for approximately 10,000 women aged 35 years and older. There were 67 cases of breast cancer. Highest rates of attendance were seen among younger women [35-44 years] and middle socioeconomic groups. Lowest rates were among those aged over 65 years and low socioeconomic groups. The rate of detection by self-examination was similar to that by health personnel examination. At all stages of screening, positive findings were most common among the high socioeconomic class. Attendance decreased steadily from first to last stages of serial screening. Although mammography is the most sensitive method of detection, because of its high cost we suggest establishing breast self-examination education programmes and encouraging women to self-examine
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Autoexamen de Mamas , Costos de la Atención en Salud , Educación en Salud , Mamografía , Tamizaje Masivo , Aceptación de la Atención de Salud , Examen Físico , Factores Socioeconómicos , Servicios Urbanos de Salud , Neoplasias de la MamaAsunto(s)
Hematopoyesis Extramedular , Pulmón/patología , Pulmón/fisiopatología , Adulto , Biopsia con Aguja , Humanos , MasculinoRESUMEN
Data on the reproductive behaviour of women in Shiraz are presented. A total of 9934 randomly selected women aged > or = 35 years of all socioeconomic levels were interviewed. The mean age at menarche +/- standard deviation was 13.96 +/- 1.23 years, mean age at first marriage was 17.10 +/- 4.24 years and mean age at first pregnancy was 19.50 +/- 3.90 years. The mean number of children was 4.56 +/- 1.70 children, although for illiterate women it was 6.76 +/- 1.76 children and for high-school- or university-educated women it was 3.36 +/- 1.70 children. The mean age at menopause was 47.80 +/- 3.78 years.
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Conducta Anticonceptiva/psicología , Reproducción , Mujeres/psicología , Adolescente , Adulto , Factores de Edad , Niño , Conducta Anticonceptiva/estadística & datos numéricos , Escolaridad , Empleo/psicología , Empleo/estadística & datos numéricos , Composición Familiar , Femenino , Humanos , Estado Civil/estadística & datos numéricos , Matrimonio/psicología , Matrimonio/estadística & datos numéricos , Edad Materna , Menarquia , Menopausia , Persona de Mediana Edad , Embarazo/psicología , Embarazo/estadística & datos numéricos , Factores Socioeconómicos , Encuestas y Cuestionarios , Mujeres/educaciónRESUMEN
In this retrospective study, 45 patients with low-grade (I-II) isthmic spondylolisthesis are reported. Spinal decompression, stabilization and fusion were performed in 19 patients (group I). Stabilization and fusion without decompressive laminectomy were performed in 26 patients (group II). The results, which are mostly encouraging, show no significant difference between the two groups.
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Descompresión Quirúrgica/instrumentación , Vértebras Lumbares , Fusión Vertebral/instrumentación , Espondilolistesis/cirugía , Adulto , Distribución de Chi-Cuadrado , Descompresión Quirúrgica/métodos , Estudios de Evaluación como Asunto , Femenino , Estudios de Seguimiento , Humanos , Región Lumbosacra , Masculino , Persona de Mediana Edad , Radiografía , Estudios Retrospectivos , Índice de Severidad de la Enfermedad , Fusión Vertebral/métodos , Espondilolistesis/diagnóstico por imagen , Espondilolistesis/patología , Resultado del TratamientoAsunto(s)
Síndrome de Budd-Chiari/cirugía , Fallo Hepático/cirugía , Trasplante de Hígado/métodos , Donadores Vivos , Adolescente , Adulto , Femenino , Hepatectomía/métodos , Humanos , Fallo Hepático/etiología , Trasplante de Hígado/fisiología , Masculino , Madres , Recolección de Tejidos y Órganos/métodosRESUMEN
Intraosseous schwannoma of T12 with burst L1 fracture is extremely rare. Here we present a report of the successful treatment and 18-month follow-up of a 46-year-old man with this complication.
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Vértebras Lumbares/lesiones , Neurilemoma/complicaciones , Fracturas de la Columna Vertebral/complicaciones , Neoplasias de la Columna Vertebral/complicaciones , Vértebras Torácicas , Accidentes de Tránsito , Humanos , Vértebras Lumbares/diagnóstico por imagen , Masculino , Persona de Mediana Edad , Neurilemoma/diagnóstico por imagen , Neurilemoma/patología , Neurilemoma/cirugía , Radiografía , Fracturas de la Columna Vertebral/diagnóstico por imagen , Neoplasias de la Columna Vertebral/diagnóstico por imagen , Neoplasias de la Columna Vertebral/patología , Neoplasias de la Columna Vertebral/cirugía , Vértebras Torácicas/diagnóstico por imagenRESUMEN
In this retrospective study, ten patients with lumbar iatrogenic instability are reported who were treated by pedicular fixation and bone grafting with an average follow-up of 18 months. Early results, which are mostly encouraging, show relief of symptoms, solid fusion of spine, and maintenance of lumbar curve with no major complications.
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Tornillos Óseos , Enfermedad Iatrogénica , Inestabilidad de la Articulación/cirugía , Vértebras Lumbares/cirugía , Fusión Vertebral/instrumentación , Anciano , Femenino , Humanos , Inestabilidad de la Articulación/diagnóstico por imagen , Inestabilidad de la Articulación/etiología , Masculino , Persona de Mediana Edad , Dolor Intratable/diagnóstico por imagen , Dolor Intratable/etiología , Dolor Intratable/cirugía , Pronóstico , Radiografía , Estudios Retrospectivos , Enfermedades de la Columna Vertebral/diagnóstico por imagen , Enfermedades de la Columna Vertebral/etiología , Enfermedades de la Columna Vertebral/cirugía , Fusión Vertebral/métodosRESUMEN
In this retrospective study, 27 acetabular fractures treated by open reduction and internal fixation with an average follow-up of 3.7 years (1.5-4.0) are reported. Reduction leaving a displacement of < or = to 2 mm was achieved in 9 hips (30%). Good or excellent results were obtained in 22 hips (82%), and in 2 patients who were referred to us after 3 weeks, we performed supra-acetabular osteotomy to obtain congruent joints with fairly good results. The most common complication was heterotopic ossification in 59% of the patients, which led to poor results in 2 patients with grade IV. Avascular necrosis of the hip occurred in 2 patients, and 1 patient developed a late deep infection, which led to osteomyelitis and fused hip.