RESUMEN
OBJECTIVE: To evaluate the relative roles of endothelium and platelets in the pathogenesis of primary RP and RP secondary to SSc. METHODS: Endothelial derived ET-1, t-PA, PAI-1, and platelet derived beta-TG, PDGF, TGF-beta were measured in 36 patients with primary RP, 14 patients with RP secondary to SSc and 30 age and sex matched controls. RESULTS: A significative increase of ET-1, t-PA, PAI-1, TGF-beta, and beta-TG were the most relevant changes in patients with RP secondary to SSc with respect to the controls. Less relevant increases of t-PA, PAI-1, PDGF, and beta-TG levels were observed in patients with primary RP vs controls. CONCLUSIONS: These data seem to confirm the involvement of endothelial cells and platelets in the pathogenesis of RP, with mild changes in primary RP and more relevant changes in RP secondary to SSc.
Asunto(s)
Biomarcadores/sangre , Endotelio/citología , Activación Plaquetaria , Enfermedad de Raynaud/fisiopatología , Esclerodermia Sistémica/complicaciones , Adulto , Endotelina-1/sangre , Endotelio/patología , Femenino , Humanos , Masculino , Persona de Mediana Edad , Inhibidor 1 de Activador Plasminogénico/sangre , Factor de Crecimiento Derivado de Plaquetas/análisis , Activador de Tejido Plasminógeno/sangre , Factor de Crecimiento Transformador beta/sangre , beta-Tromboglobulina/análisisRESUMEN
Hypertrophic osteoarthropathy (HOA) is characterized by finger clubbing, periostosis and arthritis. The pathogenesis of hypertrophic osteoarthropathy is still uncertain. Earlier studies have been focused on the potential role of platelet and endothelium in the pathogenesis of HOA. The aim of this study was to evaluate the circulating levels of endothelin-1 (ET-1), beta-thromboglobulin (beta-TG) and platelet-derived growth factor (PDGF) in 21 HOA patients. The circulating levels of ET-1, beta-TG were significantly higher in HOA patients vs healthy controls, but not vs controls with lung diseases. On the contrary, PDGF was significantly higher in HOA patients vs healthy controls and vs subjects with lung diseases. These findings suggest that "endothelium/platelet unit" may play a role in the pathogenesis of HOA, and PDGF could induce the changes observed in HOA.
Asunto(s)
Plaquetas/fisiología , Endotelio Vascular/fisiopatología , Osteoartropatía Hipertrófica Primaria/sangre , Osteoartropatía Hipertrófica Primaria/fisiopatología , Adulto , Anciano , Anciano de 80 o más Años , Endotelina-1/sangre , Femenino , Humanos , Masculino , Persona de Mediana Edad , Factor de Crecimiento Derivado de Plaquetas/análisis , Valores de Referencia , beta-Tromboglobulina/análisisRESUMEN
OBJECTIVE: Obesity is often associated with knee osteoarthritis (OA) and with chronic hyperinsulinemia. The aim of our study was to investigate the relationship between overweight patients and OA of the knee. METHODS: Forty-eight overweight outpatients (40 women and 8 men) were recruited into the study. They were separated into 2 groups: Group 1 patients with OA of the knee and Group 2 subjects without OA of the knee. Serum insulin levels were determined in all patients. RESULTS: Insulin levels were statistically higher in patients with OA (p < 0.01) compared to subjects without OA. CONCLUSION: Our data suggest that insulin may play a role in the pathogenesis of OA of the knee in overweight patients.
