Organ Impairment-Drug-Drug Interaction Database: A Tool for Evaluating the Impact of Renal or Hepatic Impairment and Pharmacologic Inhibition on the Systemic Exposure of Drugs.

The organ impairment and drug-drug interaction (OI-DDI) database is the first rigorously assembled database of pharmacokinetic drug exposure data from publicly available renal and hepatic impairment studies presented together with the maximum change in drug exposure from drug interaction inhibition studies. The database was used to conduct a systematic comparison of the effect of renal/hepatic impairment and pharmacologic inhibition on drug exposure. Additional applications are feasible with the public availability of this database.

Locus of control and success in self-initiated attempts to stop smoking.

Investigated the relationship between self-control behavior and individual differences on Rotter's I-E scale. Ss (N = 42) who were successful in self-initiated attempts to stop smoking showed a more internal locus of control than Ss who were either unsuccessful in their attempts to quit or who never attempted to quit smoking on their own. Further, it was found that Ss who succeeded in quitting were more likely to use abrupt smoking cessation techniques than those who failed in their attempts to quit smoking. The results of this study point out the importance of the locus of control orientation in designing self-control programs for the modification of smoking behavior.