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1.
J Orofac Orthop ; 84(Suppl 3): 200-209, 2023 Oct.
Artículo en Inglés | MEDLINE | ID: mdl-36169663

RESUMEN

PURPOSE: To evaluate soft tissue changes following maxillary protraction with different expansion protocols using three-dimensional (3D) stereophotogrammetry. METHODS: Pretreatment (T0) and postprotraction (T1) stereophotogrammetry and lateral cephalometric images of skeletal class III patients were included in this retrospective study. In all, 32 patients were treated either with a combination of rapid palatal expansion and facemask (RPE/FM; n = 16; mean age: 9.94 ± 0.68 years) or with alternate rapid maxillary expansion and constriction together with a facemask (Alt-RAMEC/FM; n = 16; mean age: 9.74 ± 1.35 years). As a control group 16 untreated patients were recruited (mean age: 9.46 ± 0.8 years). For superimpositioning of the 3D images taken at T0 and T1, the face was divided into defined regions and 3D and differences between the groups were evaluated using 3­matic software (Materialise Europe, Leuven, Belgium). Cephalometric analyses were also performed. RESULTS: While the increases in the cephalometric parameters SNA and ANB were significantly greater in the treatment groups, the value for SNB also increased in the control group (p < 0.05). The results of the stereophotogrammetry analyses demonstrated that the mean changes in the RPE/FM and in the Alt-RAMEC/FM groups were significantly different for the midface compared to the control group (0.33 ± 0.26 mm, 0.3 ± 0.31 mm, 0.1 ± 0.18 mm). The maximum positive, negative, and mean changes were also significantly different between the treatment and control groups for the upper lip (p < 0.05). For the lower lip and the chin significant backward movements in the RPE/FM as well as in the Alt-RAMEC/FM group (-1.06 ± 1.26 mm, -0.68 ± 0.45 mm) were observed, while the control group (0.09 ± 0.53 mm) presented changes in the opposite direction. Regarding soft tissue changes, no significant differences were found between the RPE/FM and Alt-RAMEC/FM groups. CONCLUSION: Both treatment protocols improved the soft tissue profile due to a forward movement of the midface and the upper lip, and a backward movement of the lower lip and chin, compared to the control group.

2.
Clin Psychopharmacol Neurosci ; 19(1): 112-116, 2021 Feb 28.
Artículo en Inglés | MEDLINE | ID: mdl-33508794

RESUMEN

OBJECTIVE: Monocyte to high density lipoprotein ratio (MHR) is a new instrument for giving notice inflammation, which plays a main role in schizophrenia. Thus, in this study, our goal was to investigate the possible association between MHR and schizophrenia. METHODS: The participants of this study consisted of 75 schizophrenia patients and 74 healthy individuals (control group). The Positive and Negative Syndrome Scale was used to collect data from the patient group. Complete blood count parameters and lipid profile were analyzed in all study participants. RESULTS: The patients with schizophrenia had higher MHR values (15.04 ± 3.31 in schizophrenia patients and 12.62 ± 2.99 in controls; p = 0.001). Monocyte counts and MHR of the schizophrenia patients were significantly higher than the control group. There was a significant and positive correlation between age, body mass index, severity of disease and MHR. CONCLUSION: To our knowledge, this study was the first to demonstrate inflammatory markers such as MHR levels in schizophrenia patients. Both monocyte counts and MHR values in schizophrenia patients were higher than the control group. MHR might be an available and useful inflammatory marker to evaluate inflammation in schizophrenia patients.

3.
Nord J Psychiatry ; 75(1): 73-78, 2021 Jan.
Artículo en Inglés | MEDLINE | ID: mdl-32886012

RESUMEN

BACKGROUND: Schizophrenia patients (SPP) have an increased risk of metabolic syndrome (MetS) and are twice more likely to experience diabetes mellitus and obesity than the general population. AIMS: The main purpose of this study was to assess the prevalence of MetS and its components in first-episode psychosis patients (FEPP) and SPP. METHODS: This study consisted a total of 38 untreated FEPP, 40 SPP and 41 randomly selected healthy volunteers admitted to the psychiatric outpatient clinic. The diagnosis of MetS was made based on Adult Treatment Panel III (ATP III), ATP III-A and International Diabetes Federation (IDF) criteria. RESULTS: The prevalence of MetS was 26.3, 28.9 and 31.5% according to ATP III, ATP III-A and IDF criteria in the FEPP, respectively. The prevalence of MetS was 37.5, 40 and 42.5% according to ATP III, ATP III-A and IDF criteria in the SPP, respectively. The prevalence of MetS was 9.7, 9.7 and 12.2% according to ATP III, ATP III-A and IDF criteria in the control group, respectively. The prevalence of MetS was higher in female patients than male patients based on all three diagnostic criteria. The MetS patients had a higher mean of age, a longer duration of disease, and treatment compared to patients without MetS. CONCLUSION: The current study found that FEPP and SPP had an increased prevalence of MetS. Especially, clinicians should pay attention to MetS in SPP due to the presence of risk factors, such as advanced age, being female, and long duration of disease and treatment.


Asunto(s)
Síndrome Metabólico , Trastornos Psicóticos , Esquizofrenia , Adulto , Estudios Transversales , Femenino , Humanos , Masculino , Síndrome Metabólico/epidemiología , Prevalencia , Trastornos Psicóticos/epidemiología , Factores de Riesgo , Esquizofrenia/epidemiología , Turquía/epidemiología
4.
Clin Psychopharmacol Neurosci ; 18(1): 109-115, 2020 Feb 29.
Artículo en Inglés | MEDLINE | ID: mdl-31958911

RESUMEN

OBJECTIVE: This study aims to investigate the possible relationship between plasma concentrations of apelin, visfatin and resistin levels of first episode psychosis patients and chronic schizophrenia patients. METHODS: A total number of 29 untreated patients with first episode psychosis, 30 chronic schizophrenia and 29 randomly selected weight- and body mass index-matched healthy volunteers were included. The Diagnostic and Statistical Manual of Mental Disorders 4th edition, Positive and Negative Syndrome Scale (PANSS) and Clinical Global Impression Scale were applied to the patient groups. The enzyme-linked immunosorbent assay method was used to measure plasma apelin, visfatin and resistin levels. RESULTS: There was no difference in age, marital status, occupation, and BMI between the groups. Plasma apelin levels were significantly higher in first episode psychosis group than chronic schizophrenia and control group. There was no statistically significant difference in plasma visfatin levels between the groups: first episode psychosis group, chronic schizophrenia and control group. Plasma resistin levels were higher in both first episode psychosis group and chronic schizophrenia group than the control group. There was no statistically significant correlation between plasma apelin and resistin levels and total PANSS scores in the group of patients. CONCLUSION: To our knowledge, this study is the first which investigates the plasma apelin, visfatin and resistin levels in patients with first episode psychosis and chronic schizophrenia. Based on the results of this study, apelin and resistin may be related with some central nervous system pathologies, including the severity of a psychiatric disorder.

5.
Med Sci Monit ; 22: 397-402, 2016 Feb 06.
Artículo en Inglés | MEDLINE | ID: mdl-26851233

RESUMEN

BACKGROUND Although genetic factors are risk factors for schizophrenia, some environmental factors are thought to be required for the manifestation of disease. Epigenetic mechanisms regulate gene functions without causing a change in the nucleotide sequence of DNA. Brain-derived neurotrophic factor (BDNF) is a neurotrophin that regulates synaptic transmission and plasticity. It has been suggested that BDNF may play a role in the pathophysiology of schizophrenia. It is established that methylation status of the BDNF gene is associated with fear learning, memory, and stressful social interactions. In this study, we aimed to investigate the DNA methylation status of BDNF gene in patients with schizophrenia. MATERIAL AND METHODS The study included 49 patients (33 male and 16 female) with schizophrenia and 65 unrelated healthy controls (46 male and 19 female). Determination of methylation pattern of CpG islands was based on the principle that bisulfite treatment of DNA results in conversion of unmethylated cytosine residues into uracil, whereas methylated cytosine residues remain unmodified. Methylation-specific PCR was performed with primers specific for either methylated or unmethylated DNA. RESULTS There was no significant difference in methylated or un-methylated status for BDNF promoters between schizophrenia patients and controls. The mean duration of illness was significantly lower in the hemi-methylated group compared to the non-methylated group for BDNF gene CpG island-1 in schizophrenia patients. CONCLUSIONS Although there were no differences in BDNF gene methylation status between schizophrenia patients and healthy controls, there was an association between duration of illness and DNA methylation.


Asunto(s)
Factor Neurotrófico Derivado del Encéfalo/genética , Metilación de ADN , Esquizofrenia/genética , Adulto , Factor Neurotrófico Derivado del Encéfalo/sangre , Estudios de Casos y Controles , Islas de CpG , Cartilla de ADN , Epigenómica , Femenino , Humanos , Masculino , Reacción en Cadena de la Polimerasa/métodos , Regiones Promotoras Genéticas , Esquizofrenia/sangre
6.
Noro Psikiyatr Ars ; 53(4): 328-333, 2016 Dec.
Artículo en Inglés | MEDLINE | ID: mdl-28360807

RESUMEN

INTRODUCTION: Schizophrenia is a chronic illness that negatively affects the quality of life and psychosocial functions. Defined criteria to assess remission in schizophrenia are considered to be useful in the long-term follow-up of patients and in discriminating diagnostic factors. This study investigated the quality of life and functionality in schizophrenia patients in symptomatic remission (R-Sch) and not in remission (Non-R-Sch). METHODS: Sociodemographic data were collected for 40 R-Sch and 40 Non-R-Sch patients, and the following scales were administered: the Clinical Global Impression-Severity (CGI-S) Scale; Positive and Negative Syndrome Scale (PANSS), World Health Organization Quality of Life Questionnaire-Short Form, Turkish Version (WHOQOL-BREF-TR), Quality of Life Scale for Schizophrenia Patients (QLS), and Global Assessment of Functioning Scale (GAF). RESULTS: The total and all subscale scores of PANSS and the CGI-S score were significantly lower in the R-Sch group than in the Non-R-Sch group, whereas the GAF scores and all subscales of QLS and WHOQOL-BREF-TR were significantly higher. CONCLUSION: This study demonstrates that improvement in symptoms in schizophrenia patients improves quality and functionality in all areas of life, suggesting that an improvement in symptoms is the most important determinant of functional recovery in the treatment of schizophrenia.

7.
Neuropsychiatr Dis Treat ; 11: 2629-33, 2015.
Artículo en Inglés | MEDLINE | ID: mdl-26508858

RESUMEN

OBJECTIVE: The relationship between platelet activation and psychiatric disorders has been shown in previous work. Mean platelet volume (MPV) is a measure of platelet size and a good indicator of platelet activity, which increases in cardiovascular diseases (CVDs). It is known that anxiety is a considerable factor in the etiology of mortality in CVDs. The aim of the present study was to investigate any probable difference in the MPV of patients with panic disorder (PD). METHODS: Sixty-one drug-free patients, aged 18-65 years and diagnosed with PD according to the Diagnostic and Statistical Manual of Mental Disorders, Fourth Edition, were included in the study, along with 63 healthy age- and sex-matched volunteers. The body mass index (BMI) was calculated and MPV measured for each subject. RESULTS: The MPV was found to be higher in the PD group compared to the control group (P=0.004). There were no significant differences between the two groups in terms of platelet count or BMI. CONCLUSION: Alterations in platelet activity may be a reflection of abnormal 5-hydroxytryptamine (5-HT) 1A receptor function in the central nervous system of subjects with a diagnosis of PD. These findings may elucidate the relationship between CVDs and PD. The findings of the present study suggest that MPV is increased in PD patients.

8.
Psychiatry Res ; 229(1-2): 200-5, 2015 Sep 30.
Artículo en Inglés | MEDLINE | ID: mdl-26213375

RESUMEN

Increasing evidence shows that oxidative stress plays a role in the pathophysiology of schizophrenia. But there is not any study which examines the effects of oxidative stress on DNA in schizophrenia patients. Therefore we aimed to assess the oxidative stress levels and oxidative DNA damage in schizophrenia patients with and without symptomatic remission. A total of 64 schizophrenia patients (38 with symptomatic remission and 26 without symptomatic remission) and 80 healthy volunteers were included in the study. 8-hydroxydeoxyguanosine (8-OHdG), total oxidant status (TOS) and total antioxidant status (TAS) were measured in plasma. TOS, oxidative stress index (OSI) and 8-OHdG levels were significantly higher in non-remission schizophrenic (Non-R-Sch) patients than in the controls. TOS and OSI levels were significantly higher in remission schizophrenic (R-Sch) patients than in the controls. TAS level were significantly lower and TOS and OSI levels were significantly higher in R-Sch patients than in Non-R-Sch patients. Despite the ongoing oxidative stress in patients with both R-Sch and Non-R-Sch, oxidative DNA damage was higher in only Non-R-Sch patients compared to controls. It is suggested that oxidative stress can cause the disease via DNA damage, and oxidative stress plays a role in schizophrenia through oxidative DNA damage.


Asunto(s)
Daño del ADN/fisiología , Estrés Oxidativo/fisiología , Esquizofrenia/sangre , Esquizofrenia/diagnóstico , Adulto , Biomarcadores/sangre , Estudios Transversales , Femenino , Humanos , Masculino , Persona de Mediana Edad , Oxidantes/sangre , Inducción de Remisión
9.
Can Urol Assoc J ; 9(1-2): E10-3, 2015.
Artículo en Inglés | MEDLINE | ID: mdl-25624960

RESUMEN

INTRODUCTION: We prospectively analyzed parental anxiety and outcomes of the SmartClamp circumcision and the classic surgical dissection technique. METHODS: A total of 250 boys underwent circumcision between 2009 and 2012 at Kars State Hospital and Kafkas University Faculty of Medicine in Turkey. The initial 125 children were circumcised by conventional dissection method and the remaining children were operated on with a SmartClamp device. Children in both groups were compared in terms of bleeding, infection, penile edema, operative time, cosmetic result, length of the inner mucosal layer, and parental anxiety. We used a State-Trait Anxiety Inventory (STAI) form to gauge how the circumcision affected parental anxiety. This form was completed by parents on postoperative day 2. RESULTS: There were no statistically significant differences among the 2 groups in terms of age, bleeding, infection, and cosmetic displeasure (p > 0.05). The STAI scores of the parents from the SmartClamp group were statistically higher than that of the other group (p < 0.001). Penile edema was more common in the SmartClamp group (p = 0.039). However, the mean operative time was statistically shorter (p < 0.001) and the inner mucosal length was significantly longer in the SmartClamp group (p < 0.001). CONCLUSION: Circumcision with the SmartClamp device was faster. Cosmetic results and complication rates were similar. Unfortunately, this technique seemed to entail the disadvantages of longer mucosal length, penile edema, and higher parental anxiety. Urologists should keep these points in mind when choosing a technique.

10.
Acta Derm Venereol ; 93(6): 679-83, 2013 Nov.
Artículo en Inglés | MEDLINE | ID: mdl-23572177

RESUMEN

Acne is one of the most common dermatological diseases, and obsessive compulsive disorder is among the most frequent psychiatric conditions seen in dermatology clinics. Comorbidity of these conditions may therefore be expected. The aim of this study was to measure obsessive compulsive symptoms and quality of life in patients with acne vulgaris, compare them with those of healthy control subjects, and determine whether there is any predictive value of obsessive compulsive symptoms for quality of life in patients with acne. Obsessive compulsive symptoms and quality of life measurements of 146 patients with acne vulgaris and 94 healthy control subjects were made using the Maudsley Obsessive Compulsive Questionnaire and Short Form-36 in a cross-sectional design. Patients with acne vulgaris had lower scores for physical functioning, physical role dysfunction, general health perception, vitality, and emotional role dysfunction. They also had higher scores for checking, slowness, and rumination. The only predictor of physical functioning and vitality dimensions of health-related quality of life in these patients was rumination score. Obsessive compulsive symptoms in patients with acne vulgaris are higher than in controls, and this may correlate with both disease severity and quality of life for patients.


Asunto(s)
Acné Vulgar/psicología , Trastorno Obsesivo Compulsivo/psicología , Calidad de Vida , Acné Vulgar/diagnóstico , Acné Vulgar/fisiopatología , Adolescente , Adulto , Estudios de Casos y Controles , Estudios Transversales , Femenino , Humanos , Masculino , Trastorno Obsesivo Compulsivo/diagnóstico , Trastorno Obsesivo Compulsivo/fisiopatología , Valor Predictivo de las Pruebas , Escalas de Valoración Psiquiátrica , Índice de Severidad de la Enfermedad , Encuestas y Cuestionarios , Adulto Joven
11.
Case Rep Ophthalmol ; 4(1): 64-8, 2013 Jan.
Artículo en Inglés | MEDLINE | ID: mdl-23616766

RESUMEN

PURPOSE: The aim of this report is to present a case of premacular hemorrhage in a 37-week pregnant woman with concurrent presence of postpartum depression secondary to her ocular disease. METHODS: A 27-year-old woman in her 37th week of pregnancy presented with Valsalva retinopathy, which occurred in her left eye secondary to severe coughing. Her visual acuity was reduced to perception of hand motions, and she was agitated because of the loss of vision. The patient, who gave birth by cesarean section, was admitted for control examination 2 weeks after birth. No change was observed in premacular hemorrhage in control examination. However, the patient's relatives stated that the patient was very agitated and disinterested in her baby. For this reason, the patient was referred to the psychiatry clinic, and she was diagnosed with postpartum depression. The anatomical location of the premacular hemorrhage was determined by spectral domain optical coherence tomography. RESULTS: Neodymium yttrium aluminum garnet (Nd:YAG) laser hyaloidotomy was performed to her left eye on the same day. Rapid release of premacular hemorrhage into the vitreous cavity was observed immediately after Nd:YAG laser application. Two days after the application, the patient's visual acuity had improved to 20/20. The clinical improvement positively impacted on the patient's mood. CONCLUSION: In pregnant patients suffering from Valsalva retinopathy during the postpartum period, posterior hyaloidotomy by Nd:YAG laser can be implemented in terms of the patients' own and their babies' physical and mental health.

12.
Acta Dermatovenerol Croat ; 20(2): 80-3, 2012.
Artículo en Inglés | MEDLINE | ID: mdl-22726279

RESUMEN

Social anxiety is common in acne patients and the effects of isotretinoin treatment on social anxiety symptoms have not yet been thoroughly investigated. The aim of the study was to assess the effects of isotretinoin treatment on the quality of life and social anxiety symptoms in a group of acne vulgaris patients. The Liebowitz Social Anxiety Scale (LSAS) and Short Form-36 (SF-36) were administered to 39 (24 female and 15 male) patients with acne vulgaris who accepted isotretinoin treatment and agreed to participate in the study. The severity of acne was evaluated using the Global Acne Grading System. Thirty patients completed 6-month treatment with oral isotretinoin at 0.5-1.0 mg/kg daily doses. Measurements were repeated at the end of 6 months. Acne significantly improved over time in the study group. The mean performance avoidance score in LSAS and mean pain and social functioning scores in SF-36 were significantly better at the end of isotretinoin treatment. In conclusion, isotretinoin treatment improves the quality of life and social anxiety symptoms in acne patients.


Asunto(s)
Acné Vulgar/psicología , Ansiedad/prevención & control , Fármacos Dermatológicos/farmacología , Isotretinoína/farmacología , Calidad de Vida , Conducta Social , Adolescente , Adulto , Fármacos Dermatológicos/administración & dosificación , Femenino , Indicadores de Salud , Humanos , Isotretinoína/administración & dosificación , Masculino , Adulto Joven
13.
J Dermatolog Treat ; 23(4): 268-71, 2012 Aug.
Artículo en Inglés | MEDLINE | ID: mdl-21815780

RESUMEN

BACKGROUND: Depression, anxiety, and obsessive compulsive symptoms are known to be common among patients with acne vulgaris. In contrast to earlier reports, a number of recent studies suggested isotretinoin to be beneficial for depression and anxiety symptoms in acne patients. Moreover, its effects on obsessive compulsive symptomatology are still widely unknown. OBJECTIVES: To examine the effects of isotretinoin treatment on obsessive compulsive symptoms, depression, and anxiety in acne vulgaris patients. METHODS: The Hospital Anxiety and Depression Scale, Maudsley Obsessive Compulsive Questionnaire, and Sheehan Disability Scale were administered to 43 patients with acne vulgaris who accepted isotretinoin treatment and agreed to participate in the study. Severity of acne was evaluated with Global Acne Grading System. Thirty-three patients completed 6 months treatment with oral isotretinoin at 0.5-1.0 mg/kg daily doses. Measurements were repeated at the end of 6 months. RESULTS: Depression, anxiety, and obsessive rumination symptoms were significantly improved after isotretinoin treatment. On the other hand, obsessive doubting of acne patients was worse at the end of the treatment. There was no significant change in disease related disability of patients. CONCLUSION: Besides worsening of obsessive doubting, successful treatment with oral isotretinoin seems to be related with improvement in depression, anxiety, and obsessive rumination symptoms in acne vulgaris patients. These changes were not reflected in the disability level that acne patients have reported.


Asunto(s)
Acné Vulgar/tratamiento farmacológico , Trastornos de Ansiedad/tratamiento farmacológico , Trastorno Depresivo/tratamiento farmacológico , Fármacos Dermatológicos/uso terapéutico , Isotretinoína/uso terapéutico , Trastorno Obsesivo Compulsivo/tratamiento farmacológico , Acné Vulgar/psicología , Adolescente , Adulto , Trastornos de Ansiedad/psicología , Trastorno Depresivo/psicología , Femenino , Humanos , Masculino , Trastorno Obsesivo Compulsivo/psicología , Calidad de Vida , Índice de Severidad de la Enfermedad , Resultado del Tratamiento , Adulto Joven
14.
J Affect Disord ; 136(3): 979-82, 2012 Feb.
Artículo en Inglés | MEDLINE | ID: mdl-22119090

RESUMEN

We aimed to investigate the changes in serum adiponectin and resistin levels in patients with obsessive compulsive disorder and control groups. The serum adiponectin and resistin levels of 29 patients (16 females, 13 males) with obsessive compulsive disorder and weight, age and sex-matched 31 healthy controls (17 females, 14 males) were determined. Yale-Brown Obsessive Compulsive Scale (Y-BOCS) was applied to all groups. ELISA method was used to measure adiponectin and resistin levels. The mean adiponectin level was 11.92±2.04 ng/ml and resistin level was 13.23±2.78 ng/ml in obsessive compulsive disorder group, while it was 18.81±5.24 ng/ml and 8.17±2.53 ng/ml in control group. Changes in plasma adiponectin and resistin levels in obsessive compulsive disorder may have implications about possible cardiovascular and metabolic abnormalities seen in obsessive compulsive patients.


Asunto(s)
Adiponectina/sangre , Trastorno Obsesivo Compulsivo/sangre , Resistina/sangre , Adulto , Femenino , Humanos , Masculino , Adulto Joven
15.
Prog Neuropsychopharmacol Biol Psychiatry ; 35(2): 497-500, 2011 Mar 30.
Artículo en Inglés | MEDLINE | ID: mdl-21163317

RESUMEN

AIM: In the present study, our aim was to determine the changes in the plasma concentrations of a recently discovered peptide hormone nesfatin-1 in patients with major depressive disorder and then to make a comparison with the control group. METHOD: Subjects in the patient group were randomly selected from Mustafa Kemal University, Medical School, Research and Training Hospital, Psychiatry Department, Outpatient Clinic and subjects in the control group were selected from healthy volunteers. Healthy control subjects were matched in terms of weight and body mass index. Hamilton Depression Rating Scale (HAM-D) was applied to both groups. ELISA method was used for measurement of plasma nesfatin-1 levels. RESULTS: The average nesfatin-1 level was statistically higher in patients with major depressive disorder than in the control group (p<0.001). A positive correlation was observed between plasma nesfatin-1 levels and HAM-D scores both in the patient group (r=0.59, p<0.001) and in the control group (r=0.58, p<0.001). CONCLUSION: Our findings suggest a possible relationship between major depressive disorder and high plasma nesfatin-1 level.


Asunto(s)
Proteínas de Unión al Calcio/sangre , Proteínas de Unión al ADN/sangre , Hormonas Peptídicas/sangre , Biomarcadores/sangre , Glucemia/análisis , Trastorno Depresivo Mayor , Femenino , Humanos , Masculino , Proteínas del Tejido Nervioso , Nucleobindinas , Escalas de Valoración Psiquiátrica
16.
Turk Psikiyatri Derg ; 21(4): 319-30, 2010.
Artículo en Turco | MEDLINE | ID: mdl-21125507

RESUMEN

OBJECTIVE: We aimed to determine axis-I and axis-II diagnoses and identify gender difference in anger reactions among young adults who have difficulty controlling their anger. METHOD: Students from various faculties who had difficulty controlling their anger were invited to the psychiatry department. The SCID-I, SCID-II, Multidimensional Anger Scale, Childhood Trauma Questionnaire, Social Comparison Scale, Boratav Depression Screening Scale, and Beck Hopelessness Scale were administered to consecutive admissions of 50 males and 50 females. RESULTS: Axis-I diagnoses were present in 60% of males and 74% of females. Axis-II diagnoses were present in 28% of males and 36% of females. Somatoform disorders and impulse control disorder were higher in males, whereas anxiety disorders and mood disorders were higher in females. Depression was diagnosed in 10% of males and 36% of females. "Not being taken seriously" was the most prominent reason for anger among females. The "Revenge reactions" score was strongly correlated with the education level of the mother in both genders (in females r=0.472, p=0.001; in males r=-0.396, p=0.006). The best predictor of an axis-I diagnosis in women was the "anger symptoms" total score, whereas it was the "thoughts related to anger" subscale score in males. On the other hand, the best predictors of an axis-II diagnosis were "anxious behavior" in females and "smoking" in males. CONCLUSION: Anger is an important component of psychiatric disorders. Reaction styles and underlying psychiatric disorders vary according to gender.


Asunto(s)
Ira/fisiología , Adulto , Ansiedad/psicología , Depresión/epidemiología , Depresión/psicología , Escolaridad , Femenino , Humanos , Masculino , Madres , Caracteres Sexuales , Trastornos Somatomorfos/epidemiología , Trastornos Somatomorfos/psicología , Universidades , Adulto Joven
17.
Hum Exp Toxicol ; 29(9): 793-5, 2010 Sep.
Artículo en Inglés | MEDLINE | ID: mdl-20498036

RESUMEN

INTRODUCTION: Severe amitriptyline toxicity may cause cardiac dysrhythmias, severe hypotension, convulsions and CNS depression, including coma. Management with gastric lavage, activated charcoal, alkalinization and supportive care with mechanical ventilation, antiarrhythmics and anticonvulsants, if required, is the general approach. CASE REPORT: A 33-year-old woman who had taken overdose antidepressants (amitriptyline and tianeptine) was admitted to the emergency service. She was intubated because she had pure respiratory arrest. Besides hypotension (80/60 mmHg), she was unresponsive to verbal and painful stimuli and her Glasgow coma score was 6. Hemogram and serum biochemical parameters and electrocardiography were within normal limits. The patient was examined for substance dependence and no trace of the injector was found in the body. Patient underwent a coma cocktail (naloxone 2 mg/body, 50% dextrose 25g/body and thiamin 100 mg/body). [corrected] Activated charcoal and intravenous alkalinization by NaHCO(3) were initiated. Spontaneous respiration started again 20 min after being given the coma cocktail. She became responsive to verbal stimuli first hour after the coma cocktail, and her Glasgow coma score improved to 13. She had spent 2 days in the service and was discharged by the second day of admission, without any complications. DISCUSSION: Herein, we report successful treatment in a case of severe amitriptyline and tianeptine poisoning by naloxone in addition to the above supportive care. Naloxone treatment may have a beneficial role in lethal doses of amitriptyline ingestion because amitriptyline may affect opioid receptors.


Asunto(s)
Amitriptilina/envenenamiento , Antidepresivos Tricíclicos/envenenamiento , Naloxona/uso terapéutico , Antagonistas de Narcóticos/uso terapéutico , Tiazepinas/envenenamiento , Adulto , Sobredosis de Droga , Femenino , Humanos , Resultado del Tratamiento
18.
Brain Res ; 1297: 194-7, 2009 Nov 10.
Artículo en Inglés | MEDLINE | ID: mdl-19703427

RESUMEN

In the present study, we investigated the effects of valproic acid (VPA) on nitric oxide (NO) level, lipid peroxidation, and antioxidant enzyme activities in 21 epileptic children and 26 healthy controls. The subjects were selected from those who visited for a checkup or medical treatment at the Mustafa Kemal University Research Hospital. Serum levels of NO(-2), NO(-3), malondialdehyde (MDA), superoxide dismutase (SOD), and catalase (CAT) were analyzed by redox or enzymatic reactions and spectrophotometry. Based on the NO(-2) and NO(-3) levels, the NO concentration was about 10% higher in VPA group than in the control group (p<0.001). However, no significant difference was detected for serum MDA, SOD, and CAT levels. It is suggested that NO would play a role in the mechanism of antiepileptic effects by VPA treatment.


Asunto(s)
Anticonvulsivantes/farmacología , Antioxidantes/metabolismo , Enzimas/sangre , Epilepsia/sangre , Epilepsia/tratamiento farmacológico , Óxido Nítrico/sangre , Ácido Valproico/farmacología , Anticonvulsivantes/uso terapéutico , Biomarcadores/sangre , Catalasa/sangre , Niño , Preescolar , Pruebas de Enzimas , Epilepsia/congénito , Femenino , Humanos , Peroxidación de Lípido/efectos de los fármacos , Peroxidación de Lípido/fisiología , Masculino , Malondialdehído/sangre , Oxidación-Reducción , Estrés Oxidativo/efectos de los fármacos , Estrés Oxidativo/fisiología , Espectrofotometría , Superóxido Dismutasa/sangre , Ácido Valproico/uso terapéutico
19.
Turk Neurosurg ; 19(3): 285-7, 2009 Jul.
Artículo en Inglés | MEDLINE | ID: mdl-19621296

RESUMEN

We report the case of a 39-year-old woman with unilateral intracranial chronic subdural haematoma that occurred after epidural anesthesia for excision of a skin scar, complicated by postdural puncture headache. The patient had no history of trauma, headache, coagulation abnormalities, or neurological disorders. Most physicians encountering a case of headache after epidural or spinal anesthesia first think of a postdural puncture headache. Nonetheless, the symptoms subside within 7 days when treated with analgesics and bed rest in the majority of cases. The presence of a continued postdural puncture headache without neurological deterioration, as in this case, should prompt a search for an intracranial lesion.


Asunto(s)
Anestesia Epidural/efectos adversos , Cicatriz/cirugía , Cefalea/etiología , Hematoma Subdural Crónico/etiología , Complicaciones Posoperatorias/etiología , Adulto , Procedimientos Quirúrgicos Dermatologicos , Femenino , Cefalea/diagnóstico por imagen , Hematoma Subdural Crónico/diagnóstico por imagen , Humanos , Tomografía Computarizada por Rayos X
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