High prevalence of human papillomavirus type 66 in low-grade cervical lesions of Mexican women.

Our aim was to analyze the prevalence of high-risk human papillomavirus (HR-HPV) and its association with risk factors related to cervical lesions. We used 362 cervical samples from a transversal study to detect nineteen types from the high-risk HPV clade by highly sensitive PCR. Unexpectedly, we found a very high prevalence of HPV type 66 (32.8%), particularly in low-grade squamous intraepithelial lesions. A significant association of HPV66 with previously sexually transmitted disease was observed (p < 0.05). Our results strongly suggest that HPV66 might be indicative of cervical lesions that will not progress to cancer. HPV genotyping by methods that grouped type 66 with other HR-HPV clade types should be interpreted with caution.

Non-syndromic concomitant hypodontia and supernumerary teeth in an orthodontic population.

The simultaneous occurrence of hypodontia and supernumerary teeth in the same individual is termed 'concomitant hypo-hyperodontia' (CHH). There appears to be a correlation between CHH and some syndromes, but this anomaly is very rare in the general population. The aim of this study was to investigate the frequency of CHH in a large sample of non-syndromic orthodontic patients. The records of 2108 consecutive non-syndromic orthodontic patients aged from 7 to 16 years were examined retrospectively. Every patient had at least one panoramic radiograph. When the diagnosis of hypodontia and/or hyperodontia was made in a child under 10 years of age, a second panoramic film was taken 2-4 years later. Statistical analysis of the data was undertaken using a chi-square test. Single or multiple hypodontia was diagnosed in 137 patients (6.5 per cent), 62 males and 75 females. One or more supernumerary teeth were found in 42 patients (2 per cent), 22 males and 20 females. CHH was diagnosed in seven subjects (0.33 per cent), four males and three females. In the CHH subpopulation, the total number of absent and supernumerary teeth was nine and eight, respectively. Hypodontia always occurred in the permanent dentition and was more frequent in the mandible than in the maxilla (four versus three teeth). Supernumerary teeth were more frequent in the permanent than in the primary dentition (six versus two teeth). Five supernumeraries were located in the maxilla and three in the mandible.

Radioterapia en el cáncer de vulva. Experiencia en el Hospital de Oncología, CMN, SXXI, IMSS / Radiotherapya in cancer of the vulva. Experience at Hospital de Oncología, CMN, SXXI, IMSS

Entre 1986 y 1992, 42 pacientes con cáncer de vulva fueron tratadas en el Departamento de Radioterapia del Hospital de Oncología del CMN SXXI. La media de edad fue de 63 años. Por etapas fueron estadío I una paciente, II 5, III 25, IV 4, no clasificables cinco y dos pacientes recurrentes. el control local de la enfermedad con cirugía y/o radioterapia se obtuvo en 60 por ciento de las pacientes del grupo total, sin embargo 12 de ellas desarrollaron enfermedad recurrente y sólo tres (25 por ciento) fueron rescatadas y se encuentran libres de enfermedad para un total de 43 por ciento de pacientes sin actividad tumoral en 19 meses de mediana de seguimiento. En 27 pacientes con etapas avanzadas que no recibieron ningún manejo quirúrgico, 41 por ciento de los casos se encuentra libre de enfermedad después de radioterapia radical o preoperatoria. El promedio de dosis de radioterapia que recibieron las pacientes tratadas sólo con radioterapia fue de 6500 cG y a la vulva. La mortalidad aguda observada más frecuente fue la radiodermitis húmeda, y la tardía la fibrosis. Es necesario el tratamiento multidisciplinario de las pacientes con cáncer de vulva localmente avanzado con la finalidad de incrementar las cifras de curación