Comparison of Attachment Styles of Individuals with Opioid Use Disorder and Individuals with Obesity. / Opioid Kullanim Bozuklugu Olan Bireyler ile Obezitesi Olan Bireylerin Baglanma Biçimlerinin Karsilastirilmasi.

OBJECTIVE: The aim of this study is to identify the attachment style displayed by obese individuals and to compare it with the attachment style of individuals diagnosed with opioid use disorder (OUD) and a healthy control group. METHOD: A total of 201 participants were included in the study, consisting of 66 individuals diagnosed with obesity, 62 diagnosed with OUD and 73 healthy controls. Sociodemographic Data Form and Adult Attachment Style Scale were administered to all participants, the Addiction Profile Index (API) was administered to participants diagnosed with OUD and the Yale Food Addiction Scale was administered to those diagnosed with obesity. RESULTS: The results of the study revealed that the attachment styles of individuals diagnosed with obesity showed a similar distribution to those diagnosed with OUD, and the distribution of attachment styles in both groups was found to be different from that of the healthy control group. The mean scores for ambivalent/anxious attachment style and secure attachment style were found to be similar for the obesity group and the OUD group, while the OUD group had significantly higher avoidant attachment score. The avoidant attachment style score of OUD group increase as the severity of dependency increases. Additionally, 42.4% of the group was found to be food addicted, and in this group, the mean scores for ambivalent/ anxious attachment style were found to be significantly higher. CONCLUSION: In the study, significant similarities were obtained in terms of attachment styles among participants diagnosed with obesity and OUD. The differentiation of these similarities from the control group has increased the strength of the study.

Association of Glial Cell-Line Derived Neurotrophic Factor and Nerve Growth Factor with Duration of Untreated Psychosis and Clinical Symptoms in Drug-Naive Schizophrenia.

Background: The neurodevelopmental hypothesis is one of the most-emphasized hypotheses in the etiology of schizophrenia. Nerve growth factor (NGF) and glial cell-line derived neurotropic factor (GDNF) are neurotrophic factors that provide growth, differentiation, and survival in nerve cells in the development process. In this study, we aimed to compare the GDNF and NGF levels of schizophrenia patients with healthy controls and to analyze the relationship between the Positive and Negative Syndrome Scale (PANSS) scores, serum GDNF and NGF levels and the duration of untreated psychosis (DUP) of the patients. Methods: The study involved 45 patients with a diagnosis of schizophrenia, who had never used any antipsychotic drug, and 45 age- and sex-matched healthy participants. The participants filled a sociodemographic data form. The PANSS was applied to evaluate the clinical conditions. Before the initiation of the treatment, serum samples were collected from the patients. Results: The difference between the GDNF and NGF levels of the patient group and control group was statistically significant. The serum GDNF and NGF levels in schizophrenia patients were lower than healthy controls. No correlation was found between the DUP and serum GDNF and NGF levels. There was a positive correlation between general psychopathology and negative scores of PANSS and the DUP of patients. Conclusion: GDNF and NGF levels seem to be indicators of schizophrenia and its progress; nevertheless, we still do not have sufficient information about these neurotrophic factors. The results of our study indicate that the neurodevelopmental changes occurring at the early stages of the illness prominently affect the progress of disease, highlighting the importance of treatment in the early stages of disease.