[Immunotherapy of certain acute and chronic forms of neuroinfections (tick-borne encephalitis, multiple sclerosis, disseminated encephalomyelitis)]. / Immunoterapiia nekotorykh ostrykh i khronicheskikh form neiroinfektsii (kleshchevoi éntsefalit, rasseiannyi skleroz, rasseiannyi éntsefalomielit).

The pathogenetic community of various viral neuroinfections different in their form and course points out that the use of means targeted at correction of the immune system functions is desirable. As a result of using combined immunotherapy methods the authors have obtained positive results in treating 38 patients suffering from some acute and chronic neuroinfections (grave local forms of acute tick-borne encephalitis, progredient forms of the same encephalitis, disseminated sclerosis, disseminated encephalomyelitis). Interrelations between the immunity factors are studied, and their role in the therapeutic effect obtained is discussed. The scheme and the result of the treatment, as well as general principles of dynamic observation and treatment of those patients are presented.

[ABO system blood group ratios in patients with neuroinfections]. / O sootnosheniiakh grupp krovi sistemy ABO u bol'nykh neiroinfektsiiami.

The distribution of the ABO blood groups in 2009 patients including 1441 ones suffering from etiologically diverse neuroinfections was studied. Certain correlations between the nosological forms and groups of the diseases on the one hand, and the blood factors on the other are demonstrated. The data obtained point to a certain role of hereditary predisposition in the genesis of the neuroinfections. This predisposition predetermines the risk of the illnesses and the gravity of their course, the fact, which is of a practical importance for the clinician.

[Strategy of persistence (facts, hypotheses)]. / Strategiia persistentsii (fakty, gipotezy)

The universal phenomenon of virus persistence is considered to be a regular phenomenon primarily meeting the interests of the host. Examinations of 1112 patients with various diseases of the nervous system revealed a certain dependence of macroglobulin measles antibody upon the character of the disease and the intensity of demyelinization process. These data do not suggest the etiological role of the persisting measles virus in the genesis of multiple sclerosis and a large group of other nervous system diseases (SSPE). Similar results were obtained in analogous examinations of patients for macroglobulin mumps antibody. The results indicate the role of persisting viruses in the formation of solid specific immunity as well as their importance for nonspecific protection against other immunologically similar diseases. Virus persistence is considered to be a certain antiviral strategy of the body based on accumulation in the life course of a considerable number of persisting viruses on which both specific and nonspecific antiviral protection is founded. Congenital or acquired defects of immunity cause the development of the persisting infection and appearance of some chronic diseases of the nervous system.