[Changes in the type and amount of bone collagens in chronic suppurative otitis media]. / Izmenenie tipovogo i kolichestvennogo sootnosheniya kollagenov kostnoi tkani pri khronicheskom gnoinom srednem otite.

OBJECTIVE: Comparative assessment of the collagen-tissue interaction in the bone tissue of the middle ear structures in patients with chronic suppurative otitis media (CSOM). MATERIAL AND METHODS: A prospective study of 42 patients aged 16-60 years with CSOM admitted for reconstructive sanitizing surgery was performed. To study the collagen-tissue interaction, intraoperative samples of the bone tissue of the middle ear were used. A software calculation of vascular-stromal areas and ratios of various types of bone tissue collagen was carried out during histomorphological examination. RESULTS AND DISCUSSION: The quantitative and qualitative parameters of bone tissue collagen obtained intraoperatively in patients with CSOM were studied. The cavities of the middle ear are in the phase of a chronic purulent process, when the bone structures are morphologically disorganized according to the pathological type, and sclerosis with overgrowth of the cellular structure of the mastoid process is considered a favorable outcome for delimiting the focus of inflammation in the pyramid of the temporal bone. CONCLUSIONS: Changes in the processes of collagen remodeling of bone structures contribute to the maintenance of inflammation of the middle ear in all clinical forms of CSOM. Pathological osteogenesis can serve as an indicator of the progressive course of a purulent-destructive process in the cavities of the middle ear, which makes it possible to reliably determine the rate of bone tissue transformation to predict relapse after reconstructive and sanitizing surgery.

Comparative morphology of laser lesion sites in parenchymal organs (liver, kidney, spleen).

The inflammatory and reparative processes in the parenchymal wounds after laser coagulation are characterized by predominance of proliferative reaction. Injury foci are always spatially separated from the intact tissue. Coagulation necrosis and thrombosis lead to suppression of the exudative component of inflammation in sites of laser exposures in the liver, kidneys, and spleen. Early macrophage response stimulates proliferation of fibroblasts and formation of the fine connective tissue scar within 14 days.

[Experimental, morphological and clinical aspects of transmyocardial laser revascularization]. / Eksperimental'no-morfologicheskie i klinicheskie aspekty transmiokardial'noi lazernoi revaskuliarizatsii.

Experimental, pathomorphological and clinical data substantiating use of transmyocardial laser revascularisation in the treatment of coronary heart disease (CHD) are presented. It is shown that the objective criterion of clinical efficacy of transmyocardial laser revascularisation in 58 patients with CHD is an increase of myocardial perfusion due to neoangiogenesis. This leads to improvement of cardiac function and general state of the patients. Surgical intervention has no substantial influence on contractile function of left ventricular myocardium in patients with CHD.

[Clinico-morphologic results of laser myocardial revascularization in ischemic heart disease]. / Kliniko-morfologicheskie rezul'taty lazernoi revaskuliarizatsii miokarda pri ishemicheskoi bolezni serdtsa.

Transmyocardial laser revascularization was applied in 58 patients with ischemic heart disease. The objective criterion of the method efficiency was an increase in myocardium perfusion due to newly formed blood vessels under influence of laser irradiation. The laser treatment has improved cardiac function and general condition of the patients. The surgery did not exert considerable influence on the contractile capacity of the myocardium in the patients treated.