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Background: Exotropia control is deteriorated by post-strabismus surgery in many cases. Improving this control is considered as an important factor for success of the strabismus surgery like ocular motor alignment. Objective: To determine the therapeutic effect of postoperative eye exercises on exodeviation eye control after the strabismus surgery. Methods: Forty patients suffering from intermittent exotropia after strabismus surgery were randomly divided into experimental group and control groups. Both groups received the usual medical care, while the experimental group received different types of eye exercises using physiotherapy modalities in 24 sessions over three months (two sessions a week). The measurement of exotropia control for near target and far target using the office-based scale was done before and after the treatment. Results: There was a significant improvement in near eye control post-treatment (0.45±0.61) in the experimental group compared with control group (3.65±0.88) as the mean difference was -3.20 and 95% CI of the difference between them was -3.645--2.755 with P<0.01. Also, far eye control improved post-treatment in the experimental group (0.75±0.64) compared with control group (4.00±0.86) with mean difference of -3.250 and 95% CI of the difference between them was -3.727--2.773 with P<0.01. Conclusions: For patients with intermittent exotropia who had undergone strabismus surgery, the addition of physiotherapy exercises for the eye provided significant improvements in exotropia control for near target and far target.
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Background: Dupilumab is a human monoclonal antibody directed against the alpha subunit of the interleukin-4 receptor and inhibits the signaling of IL-4 and IL-13. It is approved for treating asthma and other type-2 inflammatory diseases. There is a conflict in the literature regarding the safety and efficacy of dupilumab. Thus, we aimed to assess the safety and efficacy of dupilumab in patients with moderate to severe asthma. Methods: Six databases (PubMed, Embase, Scopus, Web of Science, Cochrane library, and clinicaltrials.gov registry) were searched until January 2022. We included randomized controlled trials that compared dupilumab with the placebo in moderate to severe asthma patients. We extracted the data at 12 and 24 weeks and analyzed them using review manager 5.4. Findings: Thirteen trials were included. Dupilumab significantly improved the forced expiratory volume in 1 s, asthma control questionnaire score, the fraction of exhaled nitric oxide level, and immunoglobulin E level at 12 and 24 weeks (p < 0.05). However, it was associated with increased blood eosinophils at 12 and 24 weeks. Dupilumab was generally a safe agent for asthmatic patients. It showed no significant difference compared with the placebo regarding most adverse events. Conclusion: Dupilumab improves pulmonary function and reduces local and systemic inflammatory markers with minimal adverse events in patients with moderate to severe asthma.
RESUMEN
BACKGROUND: Postmastectomy lymphedema can be considered the main cause of upper extremity functional impairment in patients with breast cancer. Fatigue, pain, and limited range of motion are common symptoms. If left untreated, lymphedema causes cellulitis, which can lead to gangrene in rare cases. This study was carried out to identify and compare the therapeutic advantages of virtual reality-based exercises and proprioceptive neuromuscular facilitation for postmastectomy lymphedema. Thus, a quasi-randomized comparative study of thirty female patients with unilateral postmastectomy lymphedema was conducted. Fifteen patients performed virtual reality-based exercises as well as manual lymphatic drainage, pneumatic compression, and home programs, while the other fifteen patients performed proprioceptive neuromuscular facilitation as well as manual lymphatic drainage, pneumatic compression, and home programs. The excess arm volume between the healthy and affected limbs was estimated before and after eight sessions of treatment for both groups. In addition, the affected limb functional score was calculated. Arm volume was calculated by the truncated cone formula and girth measurements obtained by the circumferential method. The Arabic version of the QuickDASH-9 scale was used to assess extremity function. RESULTS: The excess arm volume significantly decreased in both the virtual reality group (p = 0.001) and proprioceptive neuromuscular facilitation group (p = 0.005), and there was no significant difference between the two groups (p = 0.902). Age was inversely related to the improvement percentage of the QuickDASH-9 score in the virtual reality group. The functional improvement percentage was statistically significantly different between the two groups (p = 0.045). CONCLUSION: It can be concluded that both virtual reality and proprioceptive neuromuscular facilitation have a beneficial therapeutic effect on edema in patients with unilateral postmastectomy lymphedema; neither method was found to be superior, except virtual reality was found to be superior to proprioceptive neuromuscular facilitation in motivating patients and providing visual feedback. TRIAL REGISTRATION: ClinicalTrials.gov, NCT04185181 Registered 4 December 2019 - Retrospectively registered.
