RESUMEN
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Asunto(s)
Humanos , Masculino , Persona de Mediana Edad , Cóclea/patología , Implantación Coclear/métodos , Neuroma Acústico/cirugía , Neoplasias del Oído/cirugía , Resultado del TratamientoRESUMEN
La prueba calórica es una prueba ampliamente utilizada para evaluar la función vestibular, pero las condiciones en las cuales se realiza pueden variar. Se comparó el nistagmo calórico obtenido en 57 sujetos sanos: 24 sujetos estudiados en condiciones ideales y 33 sujetos estudiados en condiciones no ideales. Se observó una disminución estadísticamente significativa de la velocidad de fase lenta en las cuatro irrigaciones realizadas a los sujetos del grupo de condiciones no ideales. Esto debe ser considerado sobre todo al sospechar afectaciones bilaterales. Ser rigurosos en las condiciones permite disminuir el riesgo de diagnóstico erróneo de déficit bilateral (AU)
The caloric test is widely used to assess vestibular function, but the conditions in which it is performed can vary. Caloric nystagmus obtained in 57 healthy subjects were compared: 24 subjects studied in ideal conditions and 33 subjects in non-ideal conditions. A statistically significant decrease in the slow phase velocity of the 4 irrigations performed on the subjects in non-ideal conditions was observed. This must be considered, especially in subjects with suspected bilateral involvement. Stringent conditions reduce the risk of misdiagnosis with bilateral deficit (AU)
Asunto(s)
Humanos , Masculino , Femenino , Adulto , Pruebas Calóricas/instrumentación , Pruebas Calóricas/métodos , Pruebas Calóricas , Voluntarios Sanos/clasificación , Voluntarios Sanos/estadística & datos numéricos , Pruebas de Función Vestibular/métodos , Nistagmo Fisiológico/fisiología , Vestíbulo del Laberinto/fisiología , Estudios Transversales/métodosRESUMEN
The caloric test is widely used to assess vestibular function, but the conditions in which it is performed can vary. Caloric nystagmus obtained in 57 healthy subjects were compared: 24 subjects studied in ideal conditions and 33 subjects in non-ideal conditions. A statistically significant decrease in the slow phase velocity of the 4 irrigations performed on the subjects in non-ideal conditions was observed. This must be considered, especially in subjects with suspected bilateral involvement. Stringent conditions reduce the risk of misdiagnosis with bilateral deficit.
Asunto(s)
Pruebas Calóricas/métodos , Nistagmo Fisiológico/fisiología , Adulto , Pruebas Calóricas/normas , Estudios Transversales , Femenino , Humanos , Masculino , Persona de Mediana Edad , Valores de Referencia , Reproducibilidad de los Resultados , Proyectos de InvestigaciónRESUMEN
OBJECTIVE: Velocity storage mechanism is a multisensory rotation estimator; it compensates for errors in the information provided by the peripheral vestibular organs by means of an adjustment in the duration of the vestibular signal. The aim of this study was to determine the activity of the velocity storage mechanism in the presence of a labyrinthine disorder, using galvanic vestibular stimulation to cause direct activation of the vestibular afferent neurons. MATERIALS AND METHODS: Forty-one subjects with definite Meniere's disease (MD) and 36 healthy volunteers were evaluated using a 20-s galvanic vestibular stimulation. RESULTS: We found a post-stimulus nystagmus overshoot exclusively in subjects with MD (47% in subjects with unilateral disease and 82% in subjects with bilateral disease), but no overshoot in healthy subjects. CONCLUSION: Because post-stimulus nystagmus overshoot is caused by the velocity storage mechanism, this finding suggests an increase in the velocity storage in subjects with a labyrinthine disease.
Asunto(s)
Enfermedad de Meniere/fisiopatología , Neuronas Aferentes/fisiología , Pruebas de Función Vestibular , Nervio Vestibular/fisiopatología , Vestíbulo del Laberinto/fisiopatología , Aceleración , Adulto , Anciano , Estimulación Eléctrica , Electronistagmografía , Femenino , Lateralidad Funcional , Humanos , Masculino , Persona de Mediana Edad , Valores de Referencia , Reflejo Vestibuloocular/fisiología , Rotación , Procesamiento de Señales Asistido por Computador , Transmisión Sináptica/fisiologíaRESUMEN
OBJECTIVE: To assess the effectiveness and response over time of intratympanic dexamethasone on the symptoms of Meniere's disease. MATERIALS AND METHODS: We performed a matched cohort study of 24 patients with Meniere's disease who were unresponsive to initial treatment and underwent 3 sessions of weekly intratympanic dexamethasone injections using a concentration of 16 mg/mL and 24 matched controls with the same characteristics with regard to vertigo spells. RESULTS: Compared with control subjects, intratympanic dexamethasone injections resulted in a decrease in the frequency of vertigo spells in the first 6-month period. In the dexamethasone-treated group, a ≥60% decrease in vertigo spells was achieved by 70.8% of patients in the first 6 months. Total remission was achieved by 20.8% of patients in the first 8 months, but after this, the effect tapered. A slight improvement in Tinnitus loudness and no changes in hearing levels were found. The stage of Meniere's disease, years from disease onset, and mean number of vertigo spells per month did not have any effects on the percentage of decrease in vertigo spells. CONCLUSION: Intratympanic dexamethasone temporarily reduces the frequency of vertigo spells during the initial months but does not remove the probability of having further spells in the future. This therapy provides a valuable tool to accomplish a rapid decrease in vertigo spells in subjects with Meniere's disease, and it is considered an alternative to chemical or surgical labyrinthectomy.