1.
Acta Anaesthesiol Scand
; 34(4): 301-3, 1990 May.
Artículo
en Inglés
| MEDLINE
| ID: mdl-1693031
RESUMEN
Most narcotics cause histamine release, both systemic and cutaneous. Whether buprenorphine causes histamine release is not yet known. We conducted intradermal tests on 11 healthy adults with buprenorphine in dilutions of 1:10,000, 1:1000, 1:100 and 1:10 and with 0.9% saline and histamine 10(-3) mol/l. The size of dermal reaction was noted after 15 and 30 min. None of the volunteers showed any cutaneous reaction suggestive of histamine release with buprenorphine. The absence of histamine-releasing activity of buprenorphine may be due to the structure of the drug resulting in its decreased basicity or to the insufficient concentration of the drug achieved at mast cell membrane.
Asunto(s)
Buprenorfina/farmacología , Liberación de Histamina/efectos de los fármacos , Adulto , Femenino , Humanos , Inyecciones Subcutáneas , Masculino , Piel/efectos de los fármacos , Piel/metabolismo
2.
Anaesthesia
; 44(12): 1009-10, 1989 Dec.
Artículo
en Inglés
| MEDLINE
| ID: mdl-2619004