A new look at the theoretical causes of endometriosis: Narrative review.

Endometriosis is a major health concern in women who have it. Unfortunately, there is no definitive cure except panhysterectomy with its sequelae including induction of premature menopause due to loss of ovaries. Therefore, revealing the causes of this puzzling disease is necessary to avoid contracting it, and to spare women the health disorders resulting from it and the difficulties of treating it. We aimed to study endometriosis with a focus on its theoretical causes. Its classification reports and theories of pathogenesis were identified and studied from available database searches. The causes of endometriosis remain mysterious. Many theories have been proposed to explain the etiology, but retrograde menstruation (RM) remains the closest in this regard. Although this theory is the most accepted in the pathogenesis of endometriosis, its causes are still a matter of debate, especially in women who do not suffer from obstructions to menstrual outflows, such as cases of congenital cervical stenosis and imperforate hymen. It is suggested in some studies that there may be a relationship between women who engage in sexual activity during menstruation and the development of endometriosis. It is concluded that endometriosis is a painful and debilitating disease. Identifying its causes is essential to control the disease and avoid any burdens on health. RM is the main theory for its pathogenesis but its causes are still uncertain. Sexual activity during menstruation may be a possible cause of RM but needs more evidence. Future studies are recommended to reveal all aspects of the pathogenesis of endometriosis.

A new hypothesis may explain human parthenogenesis and ovarian teratoma: A review study.

Parthenogenesis (PG) is a rare phenomenon occurring in humans, and understanding this may help us develop an explanation for such occurrences. Moreover, it may help reveal the cause of idiopathic ovarian teratoma (OT). We aim to explain the occurrence of PG and OT in humans based on a new hypothesis. Previous literature has been searched through relevant scientific websites and international journals on the causes and mechanisms of PG and OT in humans. The previous literature on human PG was sparse and mostly contained case reports. It appears that human PG is not as rare as previously reported but may occur spontaneously, resulting in OT formation. The difference between PG and sexual reproduction is that PG has no embryonic diversity. The biopsied embryonic samples in the PG correspond exclusively to those of the maternal side. Spontaneous PG in humans often degrades or leads to formation of OT. The cause and mechanism of spontaneous PG remain unclear in the available literature. Here, we hypothesized that in some cases the secondary oocyte and first polar body enclosed in the zona pellucida may fuse together to form a single cell that restores the diploid number of chromosomes and initiates cell division to form PG. It may go unnoticed or be represented by the OT. Future studies are recommended to investigate this hypothesis.

Impact of copper oxide nanoparticles on the cerebral cortex of adult male albino rats and the potential protective role of crocin.

The use of copper oxide nanoparticles (CUONPs) on a large-scale application is a reason for many health problems and morbidities involving most body tissues, particularly those of the nervous system. Crocin is the chemical ingredient primarily responsible for the color of saffron. It has different pharmacological effects, such as antioxidant, anticancer, and memory-improving activities. This study was conducted to elaborate the effects of CUONP exposureon the cerebellar cortical tissues of rats and explore the potential protecting role of crocin through biochemical, light microscopic, and ultrastructural examinations. Twenty four adult male albino rats were randomly divided into four equal groups: Group I (negative control); Group II (crocin-treated group; 30mg/kg body weight (BW) intraperitoneal (IP) crocin daily); Group III (CUONP-treatedgroup; 0.5-mg/kg BW IP CUONP daily); and Group IV (CUONP/crocin-treated group). After 14 days of the experiment, venous blood samples were collected to determine red blood cell (RBC), white blood cell (WBC), and hemoglobin (Hb) levels. Besides, serum malondialdehyde (MDA), glutathione peroxidase (GPx), and total antioxidant capacity (TAC) were measured. Cerebellar tissue samples were examined under light and electron microscopy along with a histomorphological analysis. CUONPs induced oxidative/antioxidative imbalance as evidenced by a significant increase in serum MDA levels and decreased GPx and TAC activities. CUONPs caused a significant decrease in RBC and Hb levels and an increase in WBC count. Histopathological alterations in the cerebellar cortex were observed. The administration of crocin showed some protection against the toxic effects of CUONPs. Crocin is suggested to have a mitigating role on oxidative stress and structure alterations in the cerebellar tissues induced by CUONPs.

Potential role of Moringa Oleifera in alleviating paracetamol-induced nephrotoxicity in rat

The kidney plays a vital role in eliminating the toxic substances and drug metabolites from blood. Therefore, it is prone to hazards in case of abuse or overdose of drugs. The aim of the work was to clarify the impact of Moringa oleifera (MO) against the nephrotoxic effect of paracetamol in adult male albino rats. Twenty-eight adult male albino rats were used in this study and divided equally into four groups (G); G1 (control G), G2 (paracetamol-treated animals), G3 (paracetamol- plus high MO-treated G), G4 (high MO-treated rats). Kidney specimens were harvested after anesthetizing the animals, and then processed for histological and DNA comet analysis. Biochemical blood investiga-tions for kidney function were also performed through assessment of serum creatinine (Cr) and blood urea nitrogen (BUN). Administration of para-cetamol resulted in genotoxicity and marked bio-chemical and renal histological changes. It caused a significant increase in Cr and BUN levels and degeneration in both proximal and distal convolut-ed tubules with glomerular changes. Administration of MO with paracetamol led to a noticeable amelioration of previous mentioned changes. Moringa oleifera is suggested to be an effectivenephroprotection against paracetamol-induced damage. Further studies are recommended to con-firm the protective role of MO using large numbers of different animal models before investigating it in humans

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