[Complex diagnosis of congenital cranial dysostosis in children]. / Kompleksnaia diagnostika vrozhdennykh kraniodizostozov u detei.

Ten patients (aged 3-15 years) with congenital cranial dysostosis were examined by a pediatrician, geneticist, gastroenterologist, neuropathologist, ophthalmologist, endocrinologist, and orthopaedist. In addition to the clinical signs characteristic of hereditary multiple developmental defects, the study revealed changes in the jaws and temporomandibular joint and local factors promoting the progress of deformations of the jaws. Manifest and inapparent pathological changes and dysfunctions in gastrointestinal organs were paralleled by dysfunctions of the central and autonomic nervous systems, risk of maxillofacial and general deformations, and signs of congenital disorders in calcium, lactic acid, and pyridoxine metabolism. The results necessitate analyses of the blood and urine and development of new methods for the diagnosis of congenital cranial dysostosis and improvement of methods for the correction of this condition.

[Preoperative bifidum-lactobacterin therapy in children with cleft lip and palate]. / Primenenie bifidum-laktobakterina v dooperatsionnom periode u detei s vrozhdennoi rasshchelinoi verkhnei guby i neba.

Microbiological and immunologic investigations of peripheric blood in 125 children were conducted. They determined a positive role of early correction with eubiotics (bifidum-lactobacterium) in children with congenital cleft lip and congenital cleft palate during 8-9 months before chiloplasty and uraniscoplasty. Using eubiotics results in normalization and restoration of the intestinal microflora, which leads to restoration of cellular and humoral immunity and to decreased rates of accompanying and postoperative complications.

[Diagnostic techniques in children with secondary deforming temporomandibular osteoarthrosis]. / Rezul'taty kompleksnogo obsledovaniia detei s vtorichym deformiruiushchim osteoartrozom visochno-nizhnecheliustnogo sustava.

The article presents the results of examination 135 children aged 2-15 years with deformities of maxillofacial system. Original screening methods of diagnosis of congenital disorders of metabolism were used. The signs of dismetabolic processes and morphofunctional disorders in gastrointestinal organs were found. These may indicate congenital and acquired genesis of metabolism-disturbances, which promote deforming of maxillofacial region and skeleton.

[Change in the drug-metabolizing function of the liver in patients in the postoperative period in relation to the type of anesthesia]. / Izmenenie farmakometaboliziruiushchei funktsii pechenii u bol'nykh v posleoperatsionnom periode v zavisimosti vida anestezii.

Anesthesia-dependent changes in pharmaco-metabolic liver function have been studied in patients operated on for cosmetic facial defects. It has been established that the postoperative period in patients subjected intraoperatively to general combined anesthesia and controlled lung ventilation was characterized by inhibited drug metabolism in the liver, which required correction of the drug doses to reduce the risk of side and toxic effects of pharmacotherapy. Patients operated on under local procaine anesthesia had no considerable changes in pharmaco-metabolic liver function in the postoperative period.

[The use of benzonal and saparal in the combined therapy of patients with acute inflammatory processes of the maxillofacial area]. / Ispol'zovanie benzonala i saparala v kompleksnoi terapii bol'nykh s ostrymi vospalitel'nymi protsessami cheliustno-litsevoi oblasti.

The efficacy of inductors and adaptogens (benzonal and saparal) in combined therapy of patients with acute maxillofacial inflammations was investigated. These agents were conducive to shortening of the treatment periods and prevented complications (chronic osteomyelitis). A sooner recovery of the disordered homeostatic constants of the body (microsomal monoxygenase activities, acetylation processes, nonspecific resistance, leukocytic index of intoxication) was achieved.

[The liver detoxification function and the nature of the adaptive reactions in patients of different ages with inflammatory processes of the maxillofacial area]. / Detoksikatsionnaia funktsiia pecheni i kharakter adaptatsionnykh reaktsii u bol'nykh razlichnogo vozrasta s vospalitel'nymi protsessami cheliustno-litsevoi oblasti.

Liver monooxygenase system activity, responsible for liver detoxication, was examined with the use of antipyrin test in children and adults suffering from maxillofacial inflammations, as was their nonspecific resistance of the body. The findings evidence that inflammatory diseases are associated with a considerable reduction of the body nonspecific resistance and with depression of the liver monooxygenase system, most marked in acute inflammations. The severity of liver detoxication function disorder is in inverse relationship with the status of the body nonspecific resistance; this factor essentially influences the length of therapy.

[Nonspecific body resistance in the acetylator phenotype of patients with odontogenic inflammatory processes in the maxillofacial area]. / Nespetsificheskaia rezistentnost' organizma v atsetiliatornyi fenotip u bol'nykh s odontogennymi vospalitel'nymi protsessami cheliustno-litsevoi oblasti.

Nonspecific resistance of the body, intensity of acetylation processes, and acetylator phenotype were studied in adults and children aged 3 to 16, suffering from maxillofacial odontogenic inflammations. The findings evidence that irrespective of the patient's age, development of maxillofacial inflammations is associated with a reduction of the body nonspecific resistance and of acetylation processes intensity, this reduction being the most marked in the patients with acute and chronic osteomyelitis. Patients with the slow acetylation type predominated among the examinees, permitting a hypothesis that this acetylation type favors the development of odontogenic inflammations.

[The incidence and structure of inflammatory diseases of the maxillofacial area based on data from the Surgical Department of Pediatric Dentistry of the 2d Clinic of the Tashkent Medical Institute]. / Chastota i struktura vospalitel'nykh zabolevanii cheliustno-litsevoi oblasti po materialam khirugicheskogo otdeleniia detskoi stomatologii pri 2-i klinike Tashkentskogo meditsinskogo instituta.

Reviews the results of studies of the incidence and structure of inflammatory diseases of the maxillofacial area over 5 years. Defines the major principles of medical rehabilitation of children suffering from inflammatory diseases. Validates the usefulness of special wards for purulent conditions at a department for pediatric oral surgery.

[Pharmacological study of the anti-inflammatory agent glyderinine]. / Farmakologicheskoe izuchenie protivovospalitel'nogo sredstva gliderinina.

In experiments on various animals glyderinine, a derivative of glycyrrhizic acid isolated from Glycyrrhiza glabra, was found to exert a pronounced anti-inflammatory effect exceeding that of hydrocortisone and amidopyrine. The mechanism of the anti-inflammatory effect was to a certain degree related to the adrenal cortex, suppression of vascular permeability and antagonism to inflammation as well. Similarly to other anti-inflammatory agents, glyderinine possesses analgesic and antipyretic properties, but unlike them it fails to suppress hemopoiesis and to cause ulceration of the gastrointestinal mucosa. The drug is of low toxicity and exerts the antiallergic effect. Glyderinine was successfully tried and recommended for a wide use as an ointment for treating skin diseases.

[The state of the microsomal oxidative system in the liver of rats with acute osteomyelitis of the mandible]. / Sostoianie mikrosomal'noi okislitel'noi sistemy pecheni krys s ostrym osteomielitom nezhnei cheliusti.

Duration of hexenal sleep and activity of main microsomal enzymes in hepatocytes were studied in experimental osteomyelitis of rat mandible. Within 7, 10 and 14 days after the osteomyelitis development content of cytochromes P-450 and b5 as well as activities of amidopyrine N-demethylase, aniline hydroxylase and NADPH cytochrome c reductase were decreased in liver cell microsomal fraction. As liver tissue monooxygenase enzymatic system is inhibited in osteomyelitis the elevated pharmacological activity and toxicity of drugs, metabolized in liver tissue, should be considered under conditions of practical use of these drugs.