1.
Chem Commun (Camb)
; 55(12): 1718-1721, 2019 Feb 05.
Artículo
en Inglés
| MEDLINE
| ID: mdl-30623966
RESUMEN
Diaminocyclohexane-Pt(ii)-phenalenyl complexes (1 and 2) showed an appropriate balance between efficacy and toxicity. Compound 2 showed nearly two-fold higher tumour growth inhibition than oxaliplatin in a murine NSCLC tumour model, when a combined drug development approach was used. The fluorescent properties of phenalenone were utilized to understand the mechanistic details of the drug.