1.
Proc Natl Acad Sci U S A
; 114(22): E4318, 2017 05 30.
Artículo
en Inglés
| MEDLINE
| ID: mdl-28536204
2.
Bioorg Med Chem Lett
; 20(7): 2344-9, 2010 Apr 01.
Artículo
en Inglés
| MEDLINE
| ID: mdl-20189807
RESUMEN
From potent and selective inhibitors of GSK3beta displaying CYP1A2 inhibition and poor PK properties, mostly linked to metabolic instability and in vivo hydrolysis of the amide bond, we were able to obtain safe and orally available inhibitors with good half lives.