1.
Bioorg Med Chem Lett
; 27(4): 750-754, 2017 02 15.
Artículo
en Inglés
| MEDLINE
| ID: mdl-28131712
RESUMEN
The ATR pathway is a critical mediator of the replication stress response in cells. In aberrantly proliferating cancer cells, this pathway can help maintain sufficient genomic integrity for cancer cell progression. Herein we describe the discovery of 19, a pyrazolopyrimidine-containing inhibitor of ATR via a strategic repurposing of compounds targeting PI3K.