[Peculiarities of the organism immune response in patients suffering ischemic cardiomyopathy].

Ischemic cardiomyopathy (ICMP) constitutes the organspecific systemic form of autoimmune pathology. Now existing hypotheses of the ICMP pathogenesis trust the multistaged course of the disease with concurrent changes in the cellular and humoral chains of immunity. Among the immune disorders there are interrelated chains, influencing the disease course severity. Dysfunction of T- and B-lymphocytes, natural cell-killers (EKK-CD16+), R-IL2 (CD25+), apoptosis (CD95+), pro- and antiinflammatory cytokines causes changes in myocardium contractility, occurrence of congestion events, chronic cardiac insufficiency.

[Significance of immunological investigations in the studying of various forms of cardiomyopathy].

The data concerning the role of the immune and inflammatory reactions activation in formation of dilatational and hypertrophic cardiomyopathy were presented. The dependence of the humoral-inflammatory disbalance progressing on the processes of the apoptosis and inflammatory cytokins level regulation, determining the immune answer disorder degree in relation with cardiomyopathy form, was established.

[The combined prevention of postoperative suppurative-septic complications in patients with a fistula of the extrahepatic bile ducts]. / Kompleksnaia profilaktika posleoperatsionnykh gnoino-septicheskikh oslozhnenii u bol'nykh so svishchom vnepechenochnykh zhelchnykh protokov.

The authors have suggested a complex scheme for immunoprophylaxis of purulent-septic complications in patients with a fistula of the bile ducts, including study of the immune status, choice of the adequate immune correctors and antibiotics which act effectively on the pathogenic microflora, at individually adjusted dosages, performance of pre- and postoperative immunocorrection and immunotropic antibiotic therapy.

[Factors of natural resistance in the surgical treatment of gastric and duodenal ulcer]. / Faktory estestvennoi rezistentnosti organizma pri khirurgicheskom lechenii iazvennoi bolezni zheludka i dvenadtsatiperstnoi kishki.

In examination of 42 patients with gastric and duodenal ulcer disease, the disorders in cellular and humoral immunity were revealed. The immunologic indices didn't normalize under the influence of the operative treatment. This is indicative of the necessity to perform the immunocorrigative therapy before the operation.

[The surgical treatment of gastric and duodenal peptic ulcers in patients living in a radionuclide-contaminated area]. / Khirurgicheskoe lechenie iazvennoi bolezni zheludka i dvenadtsatiperstnoi kishki u patsientov, prozhivaiushchikh na territorii, zagriaznennoi radionuklidami.

The state of cellular and humoral immunity in patients with gastric and duodenal ulcer disease residing at the territory contaminated with radionuclides (35 patients) and at relatively clean (42) territory, as well as in 47 virtually healthy subjects was studied. It was established that in patients residing at contaminated territory, the ulcer diseases aggravated rapidly, the complications often occurred, and the immunologic indices didn't differ from those in patients residing at relatively clean territory.