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1.
Artículo en Inglés | MEDLINE | ID: mdl-38768852

RESUMEN

OBJECTIVE: To carry out a methodologically complete validation of the Spanish version of the Keratoconus End-Points Assessment Questionnaire (KEPAQ) in a Spanish population with keratoconus. METHODS: Analytical, prospective study, including patients with keratoconus without previous surgical history, in which a measurement of quality of life was performed using the KEPAQ questionnaire, a complete exploration of the anterior pole and a corneal elevation topography with the Galilei G6 topographer. The evaluation of the psychometric characteristics of the scale in the studied population was carried out using Rasch modeling. RESULTS: A total of 140 patients with keratoconus were included, with a median age of 26.0 years, the majority (57.6%) being men. For the KEPAQ-E subscale, the median score was 69.3, with a reliability of 0.85 and an eigenvalue of the first contrast of 2.34. For the KEPAQ-F, the median score was 56.4, with a reliability of 0.88 and an eigenvalue of 2.00. All infit and outfit parameters were within normal limits for both subscales. A significant evaluation was found between the evaluations of both subscales (rho = 0.696; p < 0.001). The evaluations of the subscales and various clinical and tomographic characteristics showed a significant classification between them (p value between 0.048 y 0.001). CONCLUSION: The KEPAQ is a psychometrically robust and valid scale to evaluate quality of life in the Spanish population with keratoconus. This questionnaire can be easily used for both clinical and research aims.

2.
Arch. Soc. Esp. Oftalmol ; 95(12): 579-585, dic. 2020. tab, graf
Artículo en Español | IBECS | ID: ibc-197757

RESUMEN

OBJETIVO: Se plantea realizar un proceso de traducción y adaptación del Cuestionario KORQ al castellano y su validación en una población hispanoparlante como es la colombiana. Con ello se pretende brindar una herramienta para la medición y control del compromiso en la calidad de vida de los pacientes con esta ectasia corneal. MATERIAL Y MÉTODOS: Estudio prospectivo, analítico, en el cual 200 sujetos con diagnóstico de queratocono completaron una versión traducida del cuestionario KORQ. La validez interna del cuestionario se evaluó por medio del Alfa de Cronbach, mientras que su construcción fue evaluada por un análisis exploratorio de factores, incluyendo un análisis paralelo de Horn para la selección del número de factores subyacentes. Posteriormente, 50 pacientes fueron seleccionados nuevamente para volver a completar el cuestionario una semana después. La repetibilidad del cuestionario fue medida por la prueba de Spearman. RESULTADOS: El cuestionario KORQ en su versión en castellano mostró cierta validez interna en ambas secciones. Tanto la sección de «habilidad visual» como la de «síntomas» mostraban un comportamiento esencialmente unidimensional. La repetibilidad test-retest de la prueba fue excelente (Spearman rho > 0,95). CONCLUSIONES: El cuestionario KORQ en su versión traducida es válido en población colombiana hispanoparlante


OBJECTIVE: It is proposed to carry out a process of translation and adaptation of the "Questionnaire for Research on Keratoconus Results" (KORQ) into Spanish and its validation in a Spanish-speaking population, such as Colombia. This is intended to provide a tool for measuring and monitoring the commitment to quality of life of patients with this corneal ectasia. MATERIAL AND METHODS: A prospective analytical study was carried out, in which 200 subjects diagnosed with keratoconus completed a translated version of the KORQ questionnaire. The internal validity of the questionnaire was evaluated using Cronbach's Alpha, while its construction was evaluated by an Exploratory Factor Analysis, including a Parallel Horn Analysis for the selection of the number of underlying factors. Subsequently, 50 patients were re-selected to complete the questionnaire one week later. The repeatability of the questionnaire was measured by the Spearman test. RESULTS: The KORQ questionnaire in its Spanish version showed some internal validity in both sections. Both sections of the questionnaire showed an essentially unidimensional behaviour. The test-retest repeatability of the test was excellent (Spearman rho > 0.95). CONCLUSIONS: The translated version of the KORQ is valid in Colombian population


Asunto(s)
Humanos , Masculino , Femenino , Adolescente , Adulto Joven , Adulto , Persona de Mediana Edad , Anciano , Traducciones , Encuestas y Cuestionarios/normas , Queratocono/fisiopatología , Calidad de Vida , Estudios Prospectivos , Proyectos Piloto , Análisis Factorial , Valores de Referencia , Reproducibilidad de los Resultados , Estadísticas no Paramétricas , Colombia
3.
Arch Soc Esp Oftalmol (Engl Ed) ; 95(12): 579-585, 2020 Dec.
Artículo en Inglés, Español | MEDLINE | ID: mdl-32788064

RESUMEN

OBJECTIVE: It is proposed to carry out a process of translation and adaptation of the "Questionnaire for Research on Keratoconus Results" (KORQ) into Spanish and its validation in a Spanish-speaking population, such as Colombia. This is intended to provide a tool for measuring and monitoring the commitment to quality of life of patients with this corneal ectasia. MATERIAL AND METHODS: A prospective analytical study was carried out, in which 200 subjects diagnosed with keratoconus completed a translated version of the KORQ questionnaire. The internal validity of the questionnaire was evaluated using Cronbach's Alpha, while its construction was evaluated by an Exploratory Factor Analysis, including a Parallel Horn Analysis for the selection of the number of underlying factors. Subsequently, 50 patients were re-selected to complete the questionnaire one week later. The repeatability of the questionnaire was measured by the Spearman test. RESULTS: The KORQ questionnaire in its Spanish version showed some internal validity in both sections. Both sections of the questionnaire showed an essentially unidimensional behaviour. The test-retest repeatability of the test was excellent (Spearman rho> 0.95). CONCLUSIONS: The translated version of the KORQ is valid in Colombian population.

4.
Arch. Soc. Esp. Oftalmol ; 92(4): 166-174, abr. 2017.
Artículo en Español | IBECS | ID: ibc-161824

RESUMEN

OBJETIVO: Realizar una revisión bibliográfica para mostrar las aplicaciones clínicas actuales de la técnica de entrecruzamiento del colágeno corneal. MÉTODOS: Búsqueda exhaustiva de la bibliografía de las principales bases de datos biomédicas desde la introducción del entrecruzamiento del colágeno corneal en el campo oftalmológico. RESULTADOS: El entrecruzamiento del colágeno corneal mediante radiación UVA y riboflavina es una técnica quirúrgica en estado de evolución pero ampliamente soportada por estudios preclínicos y clínicos que apoyan su utilidad terapéutica en la prevención de la progresión en las ectasias corneales, especialmente en el queratocono, aunque también en la degeneración pelúcida marginal y en las ectasias tras cirugía queratorrefractiva. Su papel en la prevención de la ectasia iatrogénica cuando se combina inicialmente con el procedimiento ablativo con láser excimer no está suficientemente probado a día de hoy. Adicionalmente, parece tener un considerable efecto beneficioso en el control de las infecciones corneales por hongos, bacterias o amebas. Sin embargo, el efecto sobre las queratitis víricas puede ser perjudicial. El beneficio en la queratopatía bullosa parece ser transitorio. CONCLUSIONES: El entrecruzamiento del colágeno corneal puede ser usado con relativa seguridad y efectividad en pacientes con queratocono progresivo. Su uso podría considerarse en pacientes con otros tipos de ectasias y con infecciones corneales de etiología no vírica. Aún hacen falta más estudios para determinar su efectividad en la prevención de la ectasia iatrogénica


OBJECTIVE: To perform a literature review of the current clinical applications of corneal collagen cross-linking. METHODS: An exhaustive literature search was made, including the main biomedical databases, and encompassing all years since the introduction of cross-linking in ophthalmology practice. RESULTS: Corneal collagen cross-linking using UVA irradiation and riboflavin is a surgical technique that is currently being optimised, and is supported by a good amount of pre-clinical and clinical studies. These papers found show the beneficial effect of the surgery on preventing the progression of corneal ectasia, especially keratoconus, but also on pellucid marginal degeneration and keratectasia after refractive surgery. The effect of cross-linking on avoiding the occurrence of iatrogenic keratectasia when combined with a photo-ablative procedure is less clear to date. Additionally, it appears that cross-linking may have a considerable beneficial effect on controlling corneal infection caused by fungi, bacteria and amoebae. However, its effect on viral keratitis can be detrimental. The benefit on bullous keratopathy seems to be rather transient. CONCLUSIONS: Corneal collagen cross-linking may be used with relative safety and efficacy in patients with progressive keratoconus. Its use could also be considered in patients with other corneal ectasias or with corneal infections of non-viral origin. Currently, there is still a need for more studies as regards its effect on preventing iatrogenic keratectasia


Asunto(s)
Humanos , Queratocono/cirugía , Enfermedades de la Córnea/cirugía , Colágeno , Sustancia Propia/cirugía , Dilatación Patológica/cirugía , Trastornos de la Visión/cirugía , Resultado del Tratamiento , Procedimientos Quirúrgicos Refractivos/métodos
5.
Arch Soc Esp Oftalmol ; 92(4): 166-174, 2017 Apr.
Artículo en Inglés, Español | MEDLINE | ID: mdl-27914659

RESUMEN

OBJECTIVE: To perform a literature review of the current clinical applications of corneal collagen cross-linking. METHODS: An exhaustive literature search was made, including the main biomedical databases, and encompassing all years since the introduction of cross-linking in ophthalmology practice. RESULTS: Corneal collagen cross-linking using UVA irradiation and riboflavin is a surgical technique that is currently being optimised, and is supported by a good amount of pre-clinical and clinical studies. These papers found show the beneficial effect of the surgery on preventing the progression of corneal ectasia, especially keratoconus, but also on pellucid marginal degeneration and keratectasia after refractive surgery. The effect of cross-linking on avoiding the occurrence of iatrogenic keratectasia when combined with a photo-ablative procedure is less clear to date. Additionally, it appears that cross-linking may have a considerable beneficial effect on controlling corneal infection caused by fungi, bacteria and amoebae. However, its effect on viral keratitis can be detrimental. The benefit on bullous keratopathy seems to be rather transient. CONCLUSIONS: Corneal collagen cross-linking may be used with relative safety and efficacy in patients with progressive keratoconus. Its use could also be considered in patients with other corneal ectasias or with corneal infections of non-viral origin. Currently, there is still a need for more studies as regards its effect on preventing iatrogenic keratectasia.


Asunto(s)
Colágeno , Enfermedades de la Córnea/cirugía , Reactivos de Enlaces Cruzados , Humanos , Procedimientos Quirúrgicos Oftalmológicos/métodos
6.
Nepal J Ophthalmol ; 6(11): 105-8, 2014 Jan.
Artículo en Inglés | MEDLINE | ID: mdl-25341835

RESUMEN

BACKGROUND: Polyneuropathy, organomegaly, endocrinopathy, monoclonal gammopathy, and skin changes (POEMS) syndrome is an uncommon condition related to a paraneoplastic syndrome secondary to an underlying plasma cell disorder. Among the myriad of manifestations of the disease, ocular signs and symptoms are relatively prevalent, affecting about half of all patients with the disease. OBJECTIVE: To report the ocular manifestations of POEMS syndrome. CASE: A 47-year-old lady diagnosed to have POEMS syndrome presented with painless progressive visual diminution. Her color vision was impaired. There was bilateral papilloedema. CONCLUSION: POEMS syndrome should be considered among the differential diagnoses of all patients with a bilateral papilledema in which no other cause can be readily elucidated.

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